Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0699790 (
colon cancer
)
28,837
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The tumor necrosis factor-related apoptosis inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells. However, many tumors are resistant to TRAIL-induced apoptosis, and resistance mechanisms are not fully understood. To identify novel regulatory molecules of TRAIL resistance, we screened a siRNA library targeting the human kinome, and
NEK4
(NIMA-related kinase-4) was identified. Knockdown of
NEK4
sensitized TRAIL-resistant cancer cells and in vivo xenografts to cell death. In contrast, over expression of
NEK4
suppressed TRAIL-induced cell death in TRAIL-sensitive cancer cells. In addition, loss of
NEK4
resulted in decrease of the anti-apoptotic protein survivin, but an increase in apoptotic cell death. Interestingly,
NEK4
was highly upregulated in tumor tissues derived from patients with lung cancer and
colon cancer
. These results suggest that inhibition of
NEK4
sensitizes cancer cells to TRAIL-induced apoptosis by regulation of survivin expression.
...
PMID:Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death. 2760 54
