Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0684275 (
haemophilia
)
10,958
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Human factor VIII (FVIII) is a protein of the blood coagulation system that is absent or defective in patients with
haemophilia
A. A most serious complication following replacement therapy in 10-15% of patients treated with available FVIII concentrate is the development of inhibitors of FVIII (anti-FVIII). Some polymers functionalized with suitable chemical substituents which mimic part of the epitope of FVIII recognized by the inhibitors might be used in extracorporeal circulation to reduce the concentration of antibodies to FVIII. For this purpose, insoluble polystyrene bearing sulfonate and
L-tyrosine
methyl ester sulfamide groups have been synthesized. The in vitro removal of anti-FVIII inhibitors from plasmas of patients with
haemophilia
A was performed. Different chromatographic parameters were studied and optimized.
...
PMID:Synthetic sorbents for removal of factor VIII inhibitors from haemophilic A plasma. 775 40
