Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1565
p53 685
epidermal growth factor receptor 636
Mol 622
tyrosine kinase 588
EGFR 437
colon carcinoma 276
vascular endothelial growth factor 272
caspase-3 213
cytokine 203
nodal 187
NMR 184
Bcl-2 183
TNM 173
ALK 168
p21 156
CD8 138
KRAS 134
anaplastic lymphoma kinase 132
VEGF 130
AKT 125
carcinoembryonic antigen 122
tumor necrosis factor 119
FDG 117
interferon 115
E-cadherin 114
MRI 110
mTOR 110
ATP 110
glycoprotein 109
PD-L1 108
neuron-specific enolase 107
cage 107
PI3K 106
collagen 100
ERK 97
matrix metalloproteinase 96
vimentin 95
She 95
bombesin 93
IFN 93
fibronectin 92
epidermal growth factor 91
CD4 91
Ki-67 88
ras 88
MET 87
P-glycoprotein 85
p38 85
thymus 84
TNF 84
MAPK 83
cyclin D1 81
HER2 81
ERK1 81
K-ras 80
lymphoid 79
Calu 78
cytokeratin 76
proteasome 76
PD-1 74
gastrin-releasing peptide 73
PARP 73
MMP-9 72
GSH 72
IL-6 72
Epidermal growth factor receptor 72
c-myc 72
vasopressin 72
BRAF 72
polypeptide 69
MMP-2 68
IFN-gamma 68
MEK 66
urokinase-type plasminogen activator 65
IL-2 64
mucin 64
receptor tyrosine kinase 64
histone 64
fused 63
insulin 63
p16 62
extracellular signal-regulated kinase 62
interleukin-2 61
ROS 61
topoisomerase I 60
JNK 59
VEGFR2 59
synaptophysin 59
ubiquitin 58
cytochrome c 58
caspase-9 58
annexin V 58
calcitonin 57
osteosarcoma 57
TNF-alpha 56
interferon-gamma 56
endoplasmic reticulum 54
CCNU 54
CEA 54
ACTH 54
ROS1 54
caspase-8 53
survivin 53
CD31 53
somatostatin 53
granulocyte 53
catenin 52
cyclooxygenase-2 52
proliferating cell nuclear antigen 52
bcl-2 52
lactate dehydrogenase 51
EGF 51
COX-2 51
SCC 50
keratin 49
STAT3 49
serum albumin 49
thyroid transcription factor-1 49
EGF receptor 48
F10 48
PTEN 48
p27 48
hepatocyte growth factor 47
CSF 47
beta-endorphin 46
Fas 46
p63 46
enolase 45
PEG 45
rhabdomyosarcoma 45
EML4 45
TTF-1 45
endostatin 45
histone deacetylase 45
IL-8 44
IL-10 43
alkaline phosphatase 42
CD44 42
Pol 42
mutant p53 41
CD34 41
TGF-beta 41
RET 40
Vascular endothelial growth factor 40
A431 40
hemoglobin 39
phosphatase 39
chromogranin A 39
catalase 39
phosphatidylinositol 3-kinase 38
SDS 38
tumour suppressor 37
PLA 37
lectin 37
plasminogen 37
erbB-2 37
lipopolysaccharide 36
interleukin-6 36
MES 36
more...
Disease
lung carcinoma 23830
lung cancer 12580
cancer 7291
tumor 7156
carcinoma 2771
adenocarcinoma 2150
non-small cell lung cancer 1813
metastases 1736
tumor growth 1106
squamous cell carcinoma 998
melanoma 959
small cell lung cancer 589
primary tumor 516
leukemia 489
tumor progression 458
breast cancer 399
carcinogenesis 393
mesothelioma 354
tumorigenesis 331
hepatocellular carcinoma 302
lymphoma 253
lung metastases 229
sarcoma 228
MCF 227
brain metastases 227
neutropenia 212
pneumonia 179
carcinoid 178
renal cell carcinoma 176
thrombocytopenia 175
adenocarcinoma of the lung 154
fibrosarcoma 154
neuroblastoma 151
epithelial ovarian cancer 143
Thoracic 141
bronchogenic carcinoma 137
neuroendocrine carcinoma 125
tumor angiogenesis 124
solid tumor 118
anemia 118
malignant mesothelioma 116
colon cancer 115
prostate cancer 114
glioblastoma 111
myelosuppression 104
leukopenia 104
Lambert-Eaton myasthenic syndrome 99
tuberculosis 95
glioma 95
multiple myeloma 93
bronchioloalveolar carcinoma 93
chronic obstructive pulmonary disease 87
retinoblastoma 87
colorectal cancer 83
large cell carcinomas 77
stage III NSCLC 77
lung disease 75
osteosarcoma 74
lymphadenopathy 73
Hodgkin's disease 72
GSH 72
ovarian cancer 71
bone metastases 70
sarcoma 180 70
paraneoplastic syndrome 70
liver metastases 69
dysplasia 69
Small cell carcinoma 65
aggressiveness 63
depression 62
encephalitis 60
esophagitis 58
tumor vasculature 58
bladder cancer 56
Adenocarcinoma 56
neuroendocrine tumor 55
malignant pleural effusion 53
residual disease 53
neuropathy 52
pancreatic cancer 51
gastric cancer 51
thymoma 50
rash 49
emphysema 48
carcinoma of the breast 47
asthma 47
sepsis 46
rhabdomyosarcoma 46
cervical cancer 46
carcinoma of the breast 46
hypertension 45
carcinoma in situ 45
acute myeloid leukemia 44
aggression 43
squamous cell lung cancer 43
DDP 43
hypercalcemia 43
Mesothelioma 42
sepsis 41
stage I NSCLC 41
respiratory failure 40
adenoma 40
stage IV NSCLC 40
muscular atrophy 39
non-Hodgkin's lymphoma 39
Thorax 39
SDS 38
lymphoblastic leukemia 38
acute promyelocytic leukemia 37
chronic myeloid leukemia 37
SCID 37
Cushing's syndrome 37
diabetes 36
liver cancer 36
Leukemia 35
pheochromocytoma 34
B-cell lymphoma 34
uterus 33
brain tumor 33
Merkel cell carcinoma 33
carcinomatosis 33
asbestosis 32
Colon 32
Colon 32
Colon 32
Epstein 31
interstitial pneumonia 31
medullary thyroid carcinoma 31
carcinosarcoma 30
HIV 30
pneumothorax 30
DBA 30
dysphagia 29
pulmonary fibrosis 29
respiratory disease 29
empyema 28
lymphoepithelioma 28
pulmonary tuberculosis 28
choriocarcinoma 27
herpes simplex 27
WT1 27
metastatic melanoma 27
sarcoidosis 27
Mycobacterium 26
peripheral neuropathy 26
neoplastic transformation 26
ATM 26
myasthenia gravis 25
infectious diseases 25
rare disease 25
carcinoma of the esophagus 25
histiocytic lymphoma 25
confusion 24
myocardial infarction 24
amelanotic melanoma 24
head and neck cancer 24
plaque 23
chronic bronchitis 23
meningioma 23
sensory neuropathy 23
more...
Symptom
pain 151
dyspnea 144
cough 136
vomiting 98
nausea 96
diarrhea 89
fatigue 86
weakness 83
hemoptysis 77
cachexia 70
nausea and vomiting 62
chest pain 56
anorexia 50
headache 35
ataxia 31
anesthesia 30
abdominal pain 30
collapse 26
seizures 25
shortness of breath 24
splenomegaly 23
asthenia 21
myoclonus 20
constipation 18
back pain 18
discomfort 16
cerebellar ataxia 15
respiratory distress 15
paresthesia 14
Ill 13
myalgia 13
discomfort 12
erythema 11
analgesia 11
starvation 11
hoarseness 11
numbness 10
exhaustion 10
dizziness 10
dysarthria 9
epigastric pain 9
productive cough 9
sleepiness 9
acute abdomen 8
hepatomegaly 8
exertional dyspnea 8
cancer pain 7
paresis 7
vertigo 7
chronic cough 7
arthralgia 7
shoulder pain 6
lethargy 6
chills 6
angina 6
low back pain 6
polydipsia 5
polyuria 5
hyperoxia 5
blurred vision 5
facial pain 4
chorea 4
clubbing 4
stridor 4
acute abdominal pain 4
memory loss 4
insomnia 4
sore throat 3
pallor 3
neck pain 3
arm pain 3
agitation 3
photopsia 3
night sweats 3
consciousness disturbance 3
overweight 3
wheezing 3
syncope 3
bloating 3
ophthalmoplegia 3
flank pain 3
tingling 3
flushing 2
bone pain 2
dry skin 2
stigma 2
persistent cough 2
orthopnea 2
muscle stiffness 2
rigors 2
pleuritic chest pain 2
spasm 2
Gastrointestinal symptoms 2
hypercapnia 2
personality change 2
cyanosis 2
knee pain 2
hypothermia 2
emaciation 2
tinnitus 2
ENT 2
fasciculation 2
tremor 2
loin pain 2
nerve pain 1
General symptoms 1
heartburn 1
hemiplegia 1
arm weakness 1
hepatosplenomegaly 1
staggering gait 1
POA 1
orofacial pain 1
hip pain 1
atypical chest pain 1
blushing 1
partial seizure 1
leg edema 1
Scratch 1
Neurologic symptoms 1
microbial colonization 1
hypoproteinemia 1
forgetfulness 1
regurgitation 1
syncopal episodes 1
jaw pain 1
catatonia 1
decreased appetite 1
limb pain 1
ACHE 1
snoring 1
paraparesis 1
Sister Mary Joseph's nodule 1
Burning 1
pelvic pain 1
Welt 1
adenitis 1
photophobia 1
groin pain 1
HSA 1
loss of taste 1
thinning 1
hyperesthesia 1
body pain 1
DNA marker 1
dysesthesia 1
penile lesion 1
intestinal bleeding 1
despair 1
thigh pain 1
dystonia 1
acute stress 1
neuralgia 1
testicular pain 1
right upper quadrant pain 1
Physical findings 1
menometrorrhagia 1
abnormal gait 1
Spots 1
rales 1
more...
Drug
Cardiovasc 151
Gefitinib 98
Adriamycin 74
IFN-gamma 65
CSF 64
IL-2 64
ROS 60
Docetaxel 59
CTX 58
Erlotinib 55
lysine 49
Pemetrexed 44
Meth 41
Dermatol 40
Taxol 40
Vinorelbine 36
MRC 35
CPT-11 34
ADR 27
Etoposide 25
vitamin E 21
CTX 21
CTX 21
Bevacizumab 20
G-CSF 19
MAP 18
Glutathione 18
TTC 18
ADM 16
VCR 15
ascorbate 14
Paraffin 14
Tarceva 14
Irinotecan 14
Photofrin 14
ROC 14
uPA 14
Taxotere 13
Cetuximab 13
caffeine 12
NADH 12
Gel 11
CCL 11
Monit 11
Navelbine 11
Bortezomib 11
Mutagen 11
DNase I 10
CAM 10
ABC 10
IFN-beta 10
PTH 9
VCR 9
GEO 9
G418 8
NVP 8
Herceptin 8
Imatinib 8
TAT 7
Leaf 7
Alimta 7
Indomethacin 7
Spectrum 6
Tocopherol 6
Vitamin A 6
DM1 6
HCG 6
Arsenic trioxide 6
Gemzar 6
Vindesine 6
Albumin 6
Vindesine 6
ENT 6
Retinoic acid 6
CDP 6
Asthma 6
Alliance 5
Fluorescein 5
Ginseng 5
p75 5
Silica 5
CTC 5
ZnO 5
Pronase 5
Gelatin 5
Gleevec 5
Flavopiridol 5
Fluorescein 5
Filgrastim 4
ETS 4
Oxaliplatin 4
Asn 4
-deoxyadenosine 4
Check 4
Bexarotene 4
lactose 4
L-tyrosine 4
CTC 4
Doxycycline 4
ACT 4
NAG 4
Bestatin 4
RFP 4
Filgrastim 4
Lovastatin 4
SiO2 4
Panitumumab 4
Histamine 4
Dexrazoxane 3
Growth hormone 3
THF 3
CTT 3
Epoetin 3
Talc 3
IL-11 3
Doyle 3
LCM 3
LCM 3
Glycyrrhiza 3
Ethanol 3
CDX 3
Zoledronic acid 3
Podophyllotoxin 3
Sodium nitroprusside 3
Rosiglitazone 3
Sorafenib 3
Estrogens 3
Dihydro 3
AMC 3
Epoetin alfa 3
ALA 3
BH4 3
Zoledronic acid 3
Ipilimumab 3
TiO2 3
Growth hormone 3
Teniposide 3
Heme 3
Nephron 3
Angiotensin II 3
Vitamin B 3
Epoetin alfa 3
CDX 3
Adozelesin 3
PDL 3
Human Serum Albumin 3
Gallium nitrate 3
Captopril 3
Pemetrexed disodium 3
Epoetin beta 3
Prednisone 2
Hypaque 2
KGF 2
PTC 2
Nitric Oxide 2
Nimesulide 2
NovoSeven 2
Amifostine 2
Carzelesin 2
Parkin 2
more...
Enzyme
ERK 913
mitogen-activated protein kinase 312
caspase-3 180
protein kinase 128
luciferase 117
topoisomerase 97
focal adhesion kinase 95
topoisomerase 89
P-glycoprotein 85
MEK 83
protein kinase C 82
PARP 79
urokinase-type plasminogen activator 78
proteasome 78
lactate dehydrogenase 58
reverse transcriptase 53
enolase 47
caspase-9 47
catalase 45
peroxidase 43
alkaline phosphatase 42
cdc2 41
caspase-8 41
thymidylate synthase 39
phosphatidylinositol 3-kinase 38
superoxide dismutase 37
collagenase 36
ACS 35
trypsin 33
glutathione S-transferase 33
thrombin 32
ATPase 30
RNase 29
NQO1 26
thymidine kinase 26
neuraminidase 25
cathepsin B 25
ornithine decarboxylase 25
RNase 24
phosphoinositide 3-kinase 24
RNA polymerase 24
AMP-activated protein kinase 23
plasmin 23
glutathione peroxidase 23
creatine kinase 22
beta-galactosidase 21
phospholipase C 21
dihydrofolate reductase 21
APC 20
AMPK 20
lysozyme 20
calcineurin 19
ribonucleotide reductase 19
matrix metalloproteinase 2 19
SPC 18
ribonucleotide reductase 17
MDR 17
alanine aminotransferase 16
MMP 16
transcriptase 16
DNA polymerase 15
MDP 14
arginase 14
MAP 14
AMPK 13
granzyme B 12
neutrophil elastase 12
MMP-3 12
protein phosphatase 2A 12
acetylcholinesterase 12
acid phosphatase 11
NADPH oxidase 11
gamma-glutamyl transpeptidase 11
GSK 11
NOS 11
NADPH oxidase 11
glutathione reductase 11
adenylate cyclase 10
DNA methyltransferase 10
lipoxygenase 10
dihydropyrimidine dehydrogenase 10
lipase 10
tissue plasminogen activator 10
glyceraldehyde-3-phosphate dehydrogenase 10
diamine oxidase 10
cathepsin L 10
dihydropyrimidine dehydrogenase 9
aspartate aminotransferase 9
aldehyde dehydrogenase 9
MIP 9
spermidine/spermine N1-acetyltransferase 9
elastase 9
ADH 9
alcohol dehydrogenase 9
glyceraldehyde-3-phosphate dehydrogenase 9
deoxycytidine kinase 8
thromboplastin 8
phospholipase A2 8
endonuclease 8
cholinesterase 8
IKK 8
phosphodiesterase 8
caspase-1 8
aldehyde dehydrogenase 7
firefly luciferase 7
CD10 7
deaminase 7
ribonuclease 7
aldehyde dehydrogenase 7
ribonuclease 7
transglutaminase 7
STK11 7
matrix metalloproteinase 9 7
demethylase 7
PDK1 7
renin 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
thioredoxin reductase 7
hypoxanthine-guanine phosphoribosyltransferase 7
TAT 7
ACE 7
glucose-6-phosphate dehydrogenase 7
polyamine oxidase 7
DNase 6
CPT 6
CPT 6
15-lipoxygenase 6
cytidine deaminase 6
ornithine aminotransferase 6
succinate dehydrogenase 6
hyaluronidase 6
CPT 6
NO synthase 6
MTD 6
5'-nucleotidase 6
PAM 6
sialyltransferase 5
sialyltransferase 5
phosphoglycerate kinase 5
sialyltransferase 5
cathepsin G 5
thymidine phosphorylase 5
carboxylesterase 5
SST 5
chymotrypsin 5
beta-glucuronidase 5
cytosine deaminase 5
CYP3A4 5
CEP 5
tyrosinase 5
sialidase 5
PAH 5
glyceraldehyde-3-phosphate dehydrogenase 5
CEP 5
CaMKII 5
hexokinase 5
gamma-glutamylcysteine synthetase 5
farnesyltransferase 5
indoleamine 2,3-dioxygenase 5
more...
Compound
Clin 2876
Dec 1834
DNA 1504
oxygen 321
water 249
MTT 243
calcium 207
tyrosine 195
TNM 173
sodium 168
glucose 143
methionine 138
DDP 137
MDA 111
ATP 110
acetate 109
Adriamycin 106
VP-16 99
phosphate 95
sulfate 90
GSH 85
arginine 85
GSH 85
TNF 84
bromide 81
hydrogen 80
lysine 75
PEG 75
leucine 74
cysteine 70
His 70
ethanol 69
nitrogen 68
serine 68
galactose 68
MEK 68
nitric oxide 65
iodine 64
ADR 63
CTX 58
threonine 57
PEG 57
iron 56
CCNU 55
pyrene 53
Docetaxel 53
ACTH 53
retinoic acid 52
Paclitaxel 52
cAMP 52
NH2 51
Gemcitabine 51
Gemcitabine 51
SCC 50
alanine 49
CBDCA 48
methanol 48
CBDCA 48
salt 47
pyrimidine 43
pyrimidine 43
5-FU 42
zinc 42
copper 41
silver 41
SDS 40
acridine 40
potassium 37
MES 36
urea 36
MES 36
BCNU 36
Phe 35
GM1 35
PGE2 35
ACS 34
ACS 34
Asp 34
DBA 33
CPT-11 33
creatinine 32
THP 31
THP 31
fluorine 31
DBA 31
DMSO 31
DBA 30
Gly 30
CO2 29
ethyl acetate 29
N-acetylcysteine 27
ADP-ribose 26
BCG 26
AMP 25
H2O2 25
selenium 25
TEM 24
ADP 24
cadmium 23
Pac 23
Methotrexate 23
NAD 23
DPPH 23
GAL 22
aldehyde 21
hexane 21
formaldehyde 21
GlcNAc 21
ADP 20
cobalt 20
PGE 20
MMC 20
pyridine 20
proline 20
ADP 20
nicotinamide 19
MSM 19
dUTP 19
DMS 19
tryptophan 19
CAM 19
ACNU 18
glutamate 18
NAD 18
Curcumin 18
DIC 18
acetone 18
Optimal 18
hyaluronic acid 18
aldehyde 17
Asbestos 17
EDTA 17
benzoic acid 17
EDTA 17
glutamine 17
GTP 16
tryptophan 16
dichloromethane 16
MIA 16
retinol 16
tryptophan 16
ammonium 16
MDR 16
tryptophan 16
Topotecan 15
MAP 15
chromium 15
boron 15
Cardiol 15
uridine 15
silicon 15
GM3 15
chloroform 15
Topotecan 15
Insulin 15
Vimentin 15
nickel 15
VM-26 14
acetic acid 14
SN-38 14
more...