Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0684249 (
lung carcinoma
)
23,830
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
mu3 opiate receptor
subtype is expressed in human surgical specimens of both normal lung and non-small-cell
lung carcinoma
. Nitric oxide (NO) release is mediated through the mu3 receptor, and in
lung carcinoma
, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific mu opioid receptor transcripts are present in
lung carcinoma
and other cells with the mu3 profile. Our findings identify a unique role for the
mu3 opiate receptor
in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression.
...
PMID:Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release. 1065 8
