Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The therapeutic efficacy of the preoperative administration of DTIC and its benzenoid analog DM-COOK, in terms of prolongation of the life-span of mice bearing Lewis lung carcinoma lines with different metastatic potential, has been evaluated in combined experiments with surgery and postsurgical non-specific immunotherapy with the peptidoglycan monomer PGM. The effects of the presurgical selective antimetastatic treatment with the dimethyltriazenes consist of a statistically significant prolongation of the survival time of the treated mice. The activity is more pronounced, in terms of animals cured, using the tumor line which is endowed of a low ability to colonize the lungs. The addition of postsurgical immunotherapy with PGM improves the overall therapeutic efficacy of the combined treatment with triazenes and surgery, independently from the tumor line used. In general, the presurgical treatment with the benzenoid triazene DM-COOK, causes antineoplastic effects slightly better than those observed using the imidazole derivative DTIC.
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PMID:Effects of dimethyltriazenes combined with surgery and non-specific immunotherapy in mice bearing Lewis lung carcinoma lines. 401 44

The effects of preoperative treatment with dimethyltriazene p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt (DM-COOK) followed by surgery and non-specific immunotherapy with the peptidoglycan monomer PGM have been evaluated using the Lewis lung carcinoma implanted i.m. in BD2F1 female mice. The survival time of mice treated with this combination is prolonged and the percentage of animals cured is markedly increased as compared with untreated controls or with mice treated with DM-COOK or PGM alone. The synergism between DM-COOK and PGM could be attributed to the capacity of the triazene to render the treated tumor cells more antigenic, combined with the favourable effects of PGM to restore host defense mechanisms. In this combined treatment, the use of cyclophosphamide at dosages having the same activity displayed by PGM alone does not ameliorate the results obtained with DM-COOK alone.
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PMID:Effects of postsurgical immunotherapy with PGM in mice bearing Lewis lung carcinoma treated with p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt. 407 98