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Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty-two patients with chondromatous hamartoma of the lung (CHL) operated upon in one medical center in Israel during the years 1960 to 1975 were followed through the end of 1976 for occurrence of malignancy. In 51 patients, the operation followed the finding of a coin lesion in a routine chest x-ray film (32 cases) or an x-ray film taken due to symptoms related to the chest (19 cases). In one case, it followed a cytologic diagnosis of bronchogenic carcinoma. Four cases of carcinoma of the lung were observed in this group, three of them 2 to 10 years after the CHL was first observed; in the fourth the CHL was found during an operation for lung cancer. All four lung cancers were located in the same lobe as and in proximity to the CHL. Since hamartomas were randomly distributed among the lobes, this spatial association is highly significant (p = 0.0016). The risk of lung cancer in CHL patients was estimated to be 6.3 times higher than the age-sex-ethnic adjusted rate expected for the general Israeli population. No increased risk for malignancies of other sites was found.
J Thorac Cardiovasc Surg 1980 Aug
PMID:Increased risk of lung cancer in patients with chondromatous hamartoma. 740 73

The association of peripheral carcinoma of the lung with pre-existing parenchymal scars is widely known. Since blebs are usually associated with subpleural scars, it is surprising that the clinical association of peripheral carcinoma and blebs has received scant attention in the surgical literature. Four surgical cases which illustrate this association are presented. This does not imply that large bullae require exploration or excision to exclude a possible occult carcinoma, but it is reasonable to conclude that any parenchymal lesion in association with large bullae in older patients should be viewed with more than ordinary suspicion of carcinoma.
J Thorac Cardiovasc Surg 1980 Dec
PMID:"Bleb" carcinoma of the lung. 743 87

In a 49-year-old man, large-cell carcinoma of the lung was accompanied by raised serum levels of growth hormone (GH) and growth hormone-releasing hormone (GHRH) and hypertrophic osteoarthropathy. Immunohistochemically the tumour contained GHRH but not GH. The osteoarthropathy disappeared after resection of the primary tumour and did not reappear after its recurrence. The high serum GH level presumably was due to ectopic GHRH production in the tumour. The hypertrophic osteoarthropathy was not clearly attributable to these hormones.
Scand J Thorac Cardiovasc Surg 1994
PMID:Lung cancer containing growth hormone-releasing hormone associated with hypertrophic osteoarthropathy. Case report. 779 60

Between 1979 and 1989, 876 patients with non-small-cell lung carcinoma were referred to our unit for surgical treatment. One hundred forty-six patients were judged not suitable for surgical treatment on clinical, radiologic, or bronchoscopic findings. Cervical mediastinoscopy or anterior mediastinotomy (or both) showed that 151 patients had mediastinal involvement by invasion or metastases into the ipsilateral (N2 disease) or contralateral (N3 disease) superior mediastinal lymph nodes and were therefore deemed inoperable. Except for one patient who had involvement of a single nodal station at mediastinoscopy, all other patients (n = 578) undergoing thoracotomy were thought, on the basis of computed tomographic scan or mediastinal exploration (or both) not to have N2 disease. Despite our efforts to avoid surgery on patients with N2 disease, at thoracotomy routine mediastinal node dissection disclosed that 149 patients had unsuspected N2 disease. Resection was possible in 130 (87.3%) by pneumonectomy (n = 72), bilobectomy (n = 7), lobectomy (n = 49), or lesser resection (n = 2). In three patients the resection was incomplete (2.3%), but in 127 a complete resection was performed (85%). Histologic examination in these 149 patients showed that 72 tumors were squamous cell carcinoma, 54 adenocarcinoma, 14 large-cell carcinoma, and 9 of mixed type. Eight patients died in the hospital after thoracotomy. Adjuvant therapy was not used after complete resection. Complete follow-up was obtained in 134 patients and the mean follow-up period was 27.25 months (1 to 116 months). The actuarial 5-year survival for those having complete resection was 20.1%. There was a statistically significant difference favoring long-term survival in those patients with squamous cell carcinoma (p < 0.01) and those in whom only one nodal station was involved (p < 0.05). Neither the extent of resection nor the involvement of any specific nodal station influenced long-term survival. Despite rigorous preoperative investigations, routine mediastinal node dissection demonstrated mediastinal node metastasis for the first time at thoracotomy in 26% of our patients. We believe resection is justified in these patients, who have already necessarily incurred the morbidity and mortality of thoracotomy, so long as complete resection is possible.
J Thorac Cardiovasc Surg 1994 Jan
PMID:Surgical management of non-small-cell lung cancer with ipsilateral mediastinal node metastasis (N2 disease). 828 83

Of 471 patients undergoing a complete resection for non-small-cell carcinoma of the lung between 1972 and 1989, 40 patients (8.5%) had local recurrences without extrathoracic distant metastasis. Excluding 8 patients who had malignant pleural effusion, we selected 32 patients (24 with hilar-mediastinal lymph node, 6 with bronchial stump, and 2 with chest wall recurrence) from the 40 patients and assessed the significance of local control by radiotherapy. The median length of survival after disease recurrence for these 32 patients was 19 months. Of 29 patients given radiation treatment, 16 who responded to the treatment survived significantly longer than nonresponders (median survival time 27 months versus 6 months, p < 0.01). Univariate analyses of survival after recurrences in relation to various factors revealed that sex and disease-free intervals were significant prognostic factors (p < 0.05) other than the effect of radiotherapy. A multivariate analysis showed that the effect of radiotherapy was the predominant prognostic factor. From these results, we conclude that local control with radiation is beneficial in patients with solely locally recurrent tumors in terms of improved survival.
J Thorac Cardiovasc Surg 1994 Jan
PMID:Local recurrence after complete resection for non-small-cell carcinoma of the lung. Significance of local control by radiation treatment. 828 23

A prospective study was performed analyzing the bronchial resection boundaries of 120 patients operated on for lung carcinoma. The resection boundary, maximum tumor diameter, distance between tumor and resection boundary, and lymph-node stage were analyzed by serial sections of the surgical specimens (lobes and lungs). The following results were obtained: 20/120 cases (17%) displayed microscopic tumor invasion of the resection boundary (R1 status), most frequently adenocarcinoma (21%). The R1 status was closely associated with the distance between tumor and resection boundary and postsurgical lymph-node state (pN stage): all 8 tumors excised at distance 1 mm or less from the bronchial resection boundary revealed bronchial submucous tumor growth, whereas none of the tumors located more than 20 mm from the resection boundary was found to display tumor invasion of the bronchial boundary. Curative resection was noted in all 40 tumors operated at pNO stage and in only 11 cases (69%) of tumors with distant lymph-node metastases (pN3 stage). No relationship between tumor infiltration of the resection boundary and type of resection was seen. The data indicate that a) intra-operative control of bronchial resection boundaries is necessary in all lung-carcinoma patients with central tumor localization less than 20 mm from the proposed resection boundary; b) a "safety distance" between resection boundary and tumor boundary is of specific importance in bronchial carcinoma with lymph-node metastases.
Thorac Cardiovasc Surg 1993 Oct
PMID:Tumor presence at resection boundaries and lymph-node metastasis in bronchial carcinoma patients. 830 1

We performed a sleeve lobectomy on a patient with squamous-cell carcinoma of the lung who had poor pulmonary function and could not move his extremities or trunk, due to a muscular dystrophy. Lung cancer in a highly disabled patient can be resected even with a bronchoplastic procedure.
Thorac Cardiovasc Surg 1996 Oct
PMID:Sleeve lobectomy for lung carcinoma in a patient with muscular dystrophy. 894 57

Inhalative cigarette smoking is a major risk factor for atherosclerotic disease as well as primary carcinoma of the lung. On that account, this study was performed to determine the prevalence of primary lung cancer on admission in patients scheduled for vascular surgery. All patients presenting to our department for an intervention are screened for lung diseases. If this pretherapeutic examination suggests the existence of a lung tumor further diagnostic procedures are performed. Making use of a prospective computer-assisted patient-documentation system, we analysed incidental findings of lung cancer in those patients admitted for elective surgery. Between Jan. 1st 1990 and October 31st 1994, we electively treated 2214 patients with the diagnosis of vascular stenosis (n = 1711/77.3%) or atherosclerotic aneurysms (n = 503/22.7%) in our department. In 16 of these patients (m:f = 13:3; age 50-72 [mean: 61.1] years) a carcinoma of the lung was detected during preoperative diagnostic procedures, a prevalence of 0.72%. All these patients were smokers, with a daily inhalative nicotine consumption averaging 25 cigarettes per day for a mean of 35 years. 8 patients underwent a surgical (n = 6) or other invasive (n = 2) vascular interventions. In 8 patients no vascular intervention was performed because of the revealed lung carcinoma. The prevalence of lung cancer in a population of vascular patients in the present study is in accord with data of older investigations of high-risk groups. Only 2 out of 16 lung cancers were detected at a prognostically favourable stage. Smokers with symptoms of vascular disease should be carefully examined for signs of lung cancer.
Thorac Cardiovasc Surg 1996 Dec
PMID:The prevalence of lung cancer in vascular surgery patients. 902 8

The extended surgery for T4 lung carcinoma was reviewed. From literature in the last decade, the 5-year survival rate has been under 10% worldwide. However a more favorable prognosis will be expected nowadays because of the progress of perioperative intensive care and appearance of effective anticancerous agents for induction chemotherapy. We compared the results of surgery for T4 lung carcinoma from 1978 to 1989, to those from 1992 to 1997. The 3 and 5-year survivals in the former period were 6.8% respectively, however in the latter period the 3-year survival rate rose to 24.6%. In patients with T4, the prognoses are different according to the involved organs by lung carcinoma. Generally, combined resection of the trachea, carina, descending aorta and left atrium show better prognoses compared to that of the esophagus and liver. We consider that malignant pleural effusion with N2 should not be the object for panpleuropneumonectomy. In our series from 1992 to 1997 median survival time (MST) of T4 with N0 or N1 was 25.5 months, on the other hand MST with N2 or N3 was 14.2 months. Histologically patients with squamous cell carcinoma showed a better prognosis than those with adenocarcinoma. From these results, in the extended operation for T4 we may expect more favorable prognoses in cases with involvements of the trachea, carina, aorta and left atrium, and with N0 or N1, histologically squamous cell carcinoma.
Ann Thorac Cardiovasc Surg 1998 Jun
PMID:Extended operation for T4 lung carcinoma. 966 Sep 7

Preoperative diagnostic procedures in the treatment of non-small-cell lung carcinoma (NSCLC) include fiberbronchoscopy (FBS) and CT scanning of the thorax and abdomen. The introduction of double-detector helical computed tomography has led to improved image resolution which allows three-dimensional reconstruction of the bronchial tree. A special computer simulation provides a virtual endoscopic view into the inner surface of the bronchial system. In order to determine whether the so-called virtual bronchoscopy (VBS) accurately reflects the anatomic situation of the bronchial tree, neoplastic lesion, and postoperative control of sleeve resections, we performed a virtual bronchoscopy in 24 patients with NSCLC and in 6 patients following sleeve resections and compared the results with the findings of fiberoptic bronchoscopy. An anatomic computer simulation of the bronchial tree was created in 100% of the investigated patients. Central tumor stenosis or occlusion was visualized by VBS as well as by FBS. In peripheral tumorous lesions VBS revealed the correct diagnosis in only 75%. VBS, however, enables viewing beyond the stenosis. FBS remains the gold standard in the endoscopic diagnostic procedures, showing not only airway patency but also mucosal changes in the vicinity of the tumorous lesion. VBS, however, gives further information about the poststenotic area in occlusive main bronchus stenosis. Furthermore, adequate control investigation of airway patency in patients following sleeve resections or stent implantation can be performed by VBS.
Thorac Cardiovasc Surg 1998 Dec
PMID:Comparison of virtual and fiberoptic bronchoscopy. 992 59


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