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Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acquired ichthyosis was recognized in four patients, in whom the associated malignant disorders were carcinoma of the lung, breast, and cervix. This skin lesion may be a valuable clinical sign in recognizing the existence of a malignant condition. Although the emergence of an ichthyosiform dermatosis may have serious prognostic implications, it may also be useful in monitoring the course of the malignant disorder and the patient's response to therapy. The relationship to nonlymphoproliferative malignant neoplasms may be more common than has been previously recognized.
Arch Dermatol 1975 Nov
PMID:Acquired ichthyosis. A sign of nonlymphoproliferative malignant disorders. 17 43

Of 2,141 patients with scleroderma who were seen at the Mayo Clinic, Rochester, Minn, between 1959 and 1975, 78 had 87 internal malignancies. The relative frequency of the types of cancers was similar to that for the general population. The increased numbers of patients with breast and uterine carcinomas were consistent with the female preponderance in scleroderma. Contrary to previous reports, carcinoma of the lung was not the most frequent malignancy associated with scleroderma. The lymphoma-leukemia malignancies were second only to breast carcinoma in frequency, comprising about 17% of the malignancies. Both conditions developed within a three-year period in 68% (45/66) of our patients affected with systemic scleroderma, and this subgroup comprised a high mortality group. This study is not an epidemiologic one in the strictest sense, but it is a review of the experience of the Mayo Clinic with patients who have had both scleroderma and an internal malignancy.
Arch Dermatol 1979 Aug
PMID:Cancer and scleroderma. 46 24

The antigens in normal human skin defined by antibodies in patients with bullous pemphigoid (BP) were studied by Western immunoblots. Eighteen (90%) of 20 BP sera reacted to a 230-kD antigen. Seven (35%) of the sera reacted to a 160-kD antigen. Two of these reacted only to the 160-kD antigen and five also reacted to the 230-kD antigen. Antibodies to the 160-kD antigen were not present in 25 control sera obtained from normal individuals or patients with other bullous diseases. The 160-kD antigen was present in epidermal extracts of four different specimens of normal human skin but not in dermal extracts or extracts of control cells including melanoma, fibroblasts, lung carcinoma, and colon carcinoma. Monospecific sera with antibodies to either the 230-kD or to the 160-kD antigen reacted solely to their respective target antigens, but not to both, in extracts of epidermis that contained both antigens. The 160-kD antigen broke down to a 140-kD fragment, while the 230-kD antigen was unchanged in the absence of protease inhibitors. Western blot affinity purified antibody to the 160-kD antigen bound only to the basement membrane zone on the epidermal side of 1M NaCl split skin. These results indicate that a 160-kD antigen is a normal component of the basement membrane zone of human skin. The antigen is located on the epidermal side of skin split with 1M NaCl. It is a minor BP antigen, antibodies to which are present in some patients with BP.
J Invest Dermatol 1990 Jun
PMID:Identification of a 160-kD molecule as a component of the basement membrane zone and as a minor bullous pemphigoid antigen. 195 46

An unusual case of lung carcinoma with both skin metastasis and superior vena cava syndrome (SVCS) is reported. The histological type of the primary lesion as taken by punch biopsy was small cell carcinoma consisting of relatively small cells with hyperchromatic nuclei and scanty cytoplasm. The cutaneous metastatic lesion consisted of large cells with light-staining nuclei and small cells with deep-staining nuclei; it had foci of glandular elements by light microscopy. Neurosecretory granules characteristic of small cell carcinoma were found in the tumor cell cytoplasm by electron microscopy. Cutaneous metastatic rates, complication rates of SVCS, and histological varieties of small cell lung carcinomas are discussed.
J Dermatol 1989 Dec
PMID:A case of skin metastasis of lung carcinoma associated with superior vena cava syndrome. 256 Jul 83

Among 14 patients with carcinoma of the lung and scleroderma, 9 had no history of smoking. The 14 cases of primary lung carcinoma occurred in a population of 3550 patients with a diagnosis of scleroderma. Scleroderma preceded the diagnosis of lung cancer by at least 6 years in 8 cases. Scleroderma and lung carcinoma were diagnosed within 3 years of each other in 4 cases. The most frequent type of carcinoma in our series was small cell carcinoma, which accounted for 5 of the 14 cases. Our data indicate an increased risk of carcinoma of the lung in patients with scleroderma, even among nonsmokers. Small cell carcinoma of the lung is probably much more common in patients with scleroderma in whom lung carcinoma develops than is indicated by previous reports.
Arch Dermatol Res 1988
PMID:Lung cancer and scleroderma. 284 7

Two patients had regression of basal cell carcinoma while receiving systemic chemotherapy for carcinoma of the lung. The chemotherapeutic agents with some efficacy in basal cell carcinoma are reviewed. Based on our patients and data from the literature, cisplatin appears to be a drug of potential usefulness in some patients with this neoplasm.
J Am Acad Dermatol 1988 Feb
PMID:Basal cell carcinoma: response to systemic chemotherapy for lung carcinoma. 334 15

Fifty patients (26 men and 24 women) with cutaneous metastases were studied clinically and histologically. Analysis on the basis of the site of the primary tumor showed carcinoma of the lung and esophagus to be the commonest tumors responsible in men and carcinoma of the breast and ovaries the commonest in women. Metastases occurred in all areas of the skin with the chest wall the commonest site, especially in carcinoma of the breast. Most of the cutaneous metastases occurred after the primary malignancy was manifest and well advanced; only in two cases were they the presenting signs of the malignancy.
Int J Dermatol 1988 May
PMID:Metastases to the skin. 339 11

This paper reports the first case of skin metastases from small-cell carcinoma of the lung with electron microscopic confirmation. The 2 to 3-cm cutaneous lesions present on the chest and limbs were hard, nontender, smooth-surfaced, freely moveable nodules with normal appearing overlying skin. Characteristic dense-core granules 1562 +/- 123 A (SEM) in diameter were detected by electron microscopy. The detection by electron microscopy of dense-core granules may assist in confirming the diagnosis of small-cell carcinoma in cutaneous lesions with equivocal histologic findings.
J Dermatol Surg Oncol 1983 Jun
PMID:Skin metastases from small-cell carcinoma of the lung. 630 67

A case of skin metastasis of adenocarcinoma on the back of a 69-year-old female was reported. The ultrasound appearance of the tumor indicated a malignant lesion prior to the detection of a primary lung carcinoma.
J Dermatol 1994 Sep
PMID:Ultrasonographic demonstration of a skin metastasis of adenocarcinoma. 796 77

We report a 59-year-old male with Sweet's syndrome who developed small cell carcinoma of the lung one year after the initial diagnosis. To the best of our knowledge, this is the first report of Sweet's syndrome in conjunction with lung cancer. In cases of Sweet's syndrome, a search for not only hematologic disorders but also for solid tumors should be made.
J Dermatol 1994 Feb
PMID:Sweet's syndrome with small cell carcinoma of the lung. 818 10


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