Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spontaneous regression of a malignant tumor is a rare phenomenon, especially in advanced lung cancer. We reported a case of spontaneous regression of lung cancer with tracheal stenosis due to tumor invasion and multiple skin metastases. A 60-year-old man was admitted to our hospital on September 10, 1985, because of a dry cough. A chest roentgenogram showed a mass shadow in the right upper lung field. Bronchoscopic examination revealed tracheal stenosis due to the tumor mass, and transbronchial aspiration cytology (TBAC) yielded a diagnosis of large cell carcinoma of the lung. In spite of treatment by chemotherapy with cisplatin and vindesin and irradiation, dyspnea deteriorated and multiple skin metastases appeared. After Nd-YAG laser irradiation via a broncho-fiberscope to maintain his airway and ethanol injection into the skin metastases, his dyspnea improved and he was discharged on February 6, 1986. Two months after discharge all skin metastasis had completely disappeared, and the primary lesion also regressed and finally disappeared on chest roentgenogram until August, 1986. The mechanism of regression is unclear, but now he has been free of tumor clinically for four years.
 ...
PMID:[A case of spontaneous regression of lung cancer with skin metastasis]. 164 18

Tissue samples from 59 patients with lung cancer have been used to establish cell lines in culture. The primary diagnosis was small cell carcinoma in all except four. Most of the samples were of bone marrow but pleural effusions, lymph node biopsies and skin metastases were also included. The samples were usually split between HITES serum-free medium and HITES plus 2.5% foetal calf serum. A total of 19 cell lines were established and characterised. One line is large cell anaplastic lung carcinoma, four are B-lymphoblastoid and fourteen are small cell lung cancer. Considerable heterogeneity in gross morphology, neuroendocrine differentiation (by electron microscopy) and content of the enzyme L-dopa decarboxylase was seen. The use of HITES plus 2.5% foetal calf serum resulted in better establishment of cultures than did serum-free HITES.
 ...
PMID:Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma). 299 22

Antineoplaston AS2-5 is one of the degradation products of Antineoplaston A10. The chemical structure of Antineoplaston AS2-5 corresponds to phenylacetylglutamine. Toxicology studies of Antineoplaston AS2-5 injections involved 13 patients diagnosed with 15 types of neoplastic disease, including: lung cancer, 3 cases; breast, 3 cases; colon, 2 cases; and single cases of cancer of the larynx, prostate, stomach, pancreas, malignant fibrohistiocytoma, embryonal teratoma and lymphocytic lymphoma. Antineoplaston AS2-5 was injected i.v. daily through subclavian vein catheter in divided doses. The treatment was administered from 41 to 436 days. The highest dosage given was 167.6 mg/kg/24 h. The treatment was associated with only very mild side-effects, including febrile reaction in two patients and swelling of small joints in one patient. Two patients had beneficial side-effects, including increase of platelet count and increase of concentration of plasma globulin. The treatment resulted in two complete remissions, one mixed response, four cases of stabilization and six cases of increasing disease. Complete remission was achieved in squamous cell carcinoma of the larynx, stage II, and large cell undifferentiated carcinoma of the lung with lymph nodes and liver metastases. One patient had mixed response during the treatment of carcinoma of the breast with metastases to the lymph nodes, liver and skin and obtained complete remission of liver metastases but increasing disease of skin metastases. Eight patients discontinued the treatment and three patients died during the trials. The patient diagnosed with lung cancer who obtained complete remission continues to be free from the disease over 5 years after the beginning of the treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Toxicology studies on antineoplaston AS2-5 injections in cancer patients. 374 77

This paper reports the first case of skin metastases from small-cell carcinoma of the lung with electron microscopic confirmation. The 2 to 3-cm cutaneous lesions present on the chest and limbs were hard, nontender, smooth-surfaced, freely moveable nodules with normal appearing overlying skin. Characteristic dense-core granules 1562 +/- 123 A (SEM) in diameter were detected by electron microscopy. The detection by electron microscopy of dense-core granules may assist in confirming the diagnosis of small-cell carcinoma in cutaneous lesions with equivocal histologic findings.
 ...
PMID:Skin metastases from small-cell carcinoma of the lung. 630 67

We describe findings in 34 cases of lung cancer with skin metastases. In 24 men and 10 women, ages ranged from 32 to 85 years (mean, 61 years). In five, a skin lesion was the first manifestation of the underlying cancer; in another four, it was found coincidentally with detection of the lung mass. Pathologic findings included adenocarcinoma in 18 patients, large-cell carcinoma in 9, squamous cell carcinoma in 5, and small-cell carcinoma in 2. Among 87 patients with large-cell carcinoma, 9 (10.3 percent) developed cutaneous metastases. A review of 510 autopsies of primary lung cancer at Keio University from 1958 to 1992 showed 25 cases with skin metastases (4.9 percent), adenocarcinoma in 13 cases, large-cell carcinoma in 6, squamous cell carcinoma in 4, and small-cell carcinoma in 2. Skin metastases were proven in 15.4 percent of autopsy cases of large-cell carcinoma of the lung. Mean survival time from diagnosis of lung cancer was 10.3 months and that from diagnosis of skin metastasis was 4.9 months. The prognosis for patients having lung cancer with skin metastasis is thus very poor. In the review of 34 patients and 25 autopsies of lung cancer with skin metastasis, we conclude that the incidence of cutaneous metastasis is high for large-cell carcinoma and low for squamous and small-cell carcinoma.
 ...
PMID:Lung cancer with skin metastasis. 795 99

In the era of highly active antiretroviral therapy (HAART), HIV-positive individuals are increasingly presenting with non-AIDS-defining cancers such as lung carcinoma. These neoplasms tend to exhibit aggressive clinical behavior and often present with metastatic disease. We present 2 cases of lung carcinoma that manifested initially with cutaneous metastases. Both patients were men (37 and 43 years old) with known AIDS that presented with multiple skin nodules mainly on the trunk (back and shoulder). These cases demonstrate that cutaneous metastases might represent the first sign of an internal HIV-related malignancy. Recognition of skin metastases is important for prompt diagnosis and initiation of proper therapy. With the growing problem of non-AIDS-defining cancers in the current era of HAART, clinicians should be aware that skin lesions in the HIV-infected individual might represent metastatic disease.
Clin Lung Cancer 2009 Nov
PMID:Human immunodeficiency virus-associated lung carcinoma presenting as cutaneous metastases. 1990 Aug 64

Skin metastases are rare complications of internal malignancies, and most commonly arise from primary lung carcinoma (Brownstein and Helwig in Arch Dermatol 105:82-68, 1972). Metastatic cutaneous lesions have not previously been documented to arise within other skin tumours. We report our experience of a solitary pulmonary adenocarcinoma metastasis that arose within a pre-existing basal cell carcinoma in a patient with undiagnosed lung cancer. Immunohistochemistry was invaluable in confirming both the metastatic nature of the secondary skin lesion and its site of origin.
 ...
PMID:Metastatic pulmonary adenocarcinoma deposit arising within a cutaneous basal cell carcinoma: a case report. 2159 83

Lung carcinoma is one of the most frequent sources of skin metastases in male patients. Our objective was to analyse the clinical and pathological features of 30 patients with skin metastases from lung carcinoma. Cutaneous biopsies codified as 'skin metastasis from lung carcinoma' during 1988-2009 at Bellvitge Hospital (Barcelona, Spain) were reviewed. The histological types of 30 lung carcinomas (29 men, 1 woman) were squamous cell carcinoma (10 cases), undifferentiated carcinoma (7), adenocarcinoma (6), small cell carcinoma (5) and large cell carcinoma (2). The most frequent clinical presentation was as a solitary nodule (16 cases), and the most frequent site was the head (13 cases). Cutaneous metastases were present at the time of diagnosis of the lung primary tumour in 66% of cases. Skin biopsy might be helpful to establish the histological type of tumour, and thus help with therapeutic decision-making. Cutaneous metastases from lung cancer remain a poor prognostic feature.
 ...
PMID:Cutaneous metastasis from lung cancer: retrospective analysis of 30 patients. 2315 80

We report the case of a man with a seven year history of lung adenocarcinoma who was diagnosed with cutaneous lymphangitis carcinomatosa. Skin examination revealed both an asymptomatic erysepelatoid rash localized on the posterior chest and an erythematous, eczematiform, itchy rash on the right anterior chest and on the left shoulder. Histopathologic examination of biopsies of these lesions revealed the same aspect with an infiltration of the dermal lymphatics by metastatic adenocarcinomatous cells. Cutaneous lymphangitis carcinomatosa is a rare condition accounting for less than 5% of skin metastases. A literature review identified eight other cases of cutaneous lymphangitis carcinomatosa in patients with lung cancer.
Lung Cancer 2013 Jan
PMID:Cutaneous lymphangitis carcinomatosa in a patient with lung adenocarcinoma: case report and literature review. 2316 53