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Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Uveal metastases are the most frequent malign intraocular tumour, of which more than 80% are localized in the choroids. This, together with the progressive increase in its incidence, makes its study and review necessary for a correct diagnosis and treatment in current clinical practice. Etiology varies according to the sex of the patient: lung carcinoma metastasises most frequently in men and breast carcinoma in women. These tend to multifocality and are generally localized in the posterior pole. Fifty percent of cases follow an asymptomatic development, but they can cause loss of vision, scotomas, metamorphopsias and photopsias. Charactersitic ophthamoscopic examination shows a placoid, homogenous choroidal lesion with a creamy appearance. The differential diagnosis must consider the amelanotic nevus, choroidal amelanotic melanoma, choroidal haemangioma, rear scleritis, choroidal osteoma, chorioretinitis, Harada's disease, rhegmatogenous retina detachment, uveal effusion syndrome, and serous central chorioretinopathy. An exhaustive history and complete ophthalmological examination are essential to the diagnosis, to which fluorescein angiography, ocular echography, fine needle puncture aspiration (FNPA), computerized tomography and magnetic resonance can be added as complementary tests. Treatment of these tumours is usually the systemic treatment of the primary tumour; the possibilities of local treatment are observation, external radiotherapy, transpupillary thermotherapy and enucleation.
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PMID:[Choroidal metastases]. 1916

Choroidal folds were defined as folds in Bruch's membrane and the anterior choroid. A clinical, histopathological and experimental investigation was performed.Eleven cases with choroidal folds were described. These cases included exophthalmos (from lymphoid hyperplasia, thyroid disease, orbital cellulitis, post-operative swelling, and orbital hemangioma), scleritis, retinal detachment due to metastatic lung carcinoma, hypotony, papilledema and choroidal detachment.The histology of 80 unselected enucleated eyes was examined and choroidal folds were found in 23 (29%). The most common cause was choroidal thickening due to vascular engorgement, hemorrhage or inflammation. Folds were also formed by tissue compression at the edge of a choroidal tumor or scleral implant, or by scleral thickening.Choroidal folds were produced in vivo in cat's eyes by traction on the optic nerve or by hypotony after paracentesis. The irregular folds after hypotony could be oriented by traction on the optic nerve.It was hypothesized that choroidal folds are produced by any mechanism which forces Bruch's membrane to fold, and that traction on the optic nerve may play a role in the characteristic horizontal temporal orientation of choroidal folds seen in many patients.
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PMID:The origin of choroidal folds a clinical, histopathological, and experimental study. 2716 12