Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0684249 (lung carcinoma)
 23,830 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Isolated, small bowel metastases from lung carcinoma are extremely rare; only 34 cases have been previously reported. Rarer still is the presentation of lung carcinoma with a lesion metastatic to the small bowel. These 34 cases and 3 recent ones from Easton Hospital (Easton, PA) were analyzed to clarify the clinical and pathologic features of the disease. The majority of patients had a history of abdominal pain (86%), melena (23%), or nausea and vomiting (26%). Few had weight loss (16%). Twenty-one patients (57%) came to the hospital with perforation and peritonitis, including 9 in whom lung carcinoma was undiagnosed before laparotomy. Thirteen patients (34%) underwent laparotomy because of small bowel obstruction, 2 (6%) for bleeding and 1 (3%) for a mass found during work-up. Squamous cell (49%) and large cell (22%) were the most common cell types, and the jejunum was the most common site of the metastases (79%). Survival time was dismal (mean 51 days) and was unaffected by therapy to the primary site of the cancer or its metastases. The authors conclude that small bowel metastases from lung carcinoma are not uncommon and may be seen more frequently as patients live longer after their diagnosis of cancer. Small bowel metastases must be considered in any patient with both lung carcinoma and abdominal pain, and should be expected in patients with both lung carcinoma and an acute abdomen.
 ...
PMID:Small bowel metastases from primary lung carcinoma: a rarity waiting to be found? 148 99

A case of small bowel perforation and a case of small bowel obstruction as a result of metastatic lung carcinoma are presented. The surgical management of each is discussed. The patient who presented with small bowel perforation died in the immediate post-operative period, while the patient who presented with small bowel obstruction is alive and well six months later. Patients with primary lung carcinoma who present with an acute abdomen should be treated by standard surgical principles irrespective of their primary pathology.
 ...
PMID:Small bowel complications of metastatic lung carcinoma. 239 86

We report a case of lung cancer metastatic to the stomach and the jejunum. Adenocarcinoma of the lingula (T 4 N 2 M 0) was diagnosed in a 45-year-old man, who then underwent chemoradiotherapy. Bowel obstruction later developed due to jejunal metastasis. Another metastasis was detected in the stomach. Laparotomy revealed jejuno-jejuno-jejunal intussusception caused by the two lesions. The jejunal and gastric lesions were identified as metastatic large cell carcinoma arising from the lung. One month postoperatively, the patient died due to disease. The literature has demonstrated that large cell carcinoma of the lung tends to metastasizes. However, the complex bowel invagination and gastric metastasis seen in our case are rare.
 ...
PMID:[Non-small cell lung cancer metastatic to the stomach and the jejunum causing intussusception: a case report]. 965 75

A 35-year-old male with an 11-year history of intestinal pseudo-obstruction associated with an idiopathic inflammatory insult of the myenteric plexus and the presence of circulating anti-Hu antibodies developed a neurological syndrome characterized by bilateral hearing loss, deteriorating balance, an unsteady gait and difficulty in estimating distances. A similar neurological syndrome has previously been described in older patients among the paraneoplasic syndromes associated with small-cell lung carcinoma and the presence of circulating anti-Hu antibodies, but never in the rare cancer-free patients with anti-Hu-associated chronic idiopathic intestinal pseudo-obstruction. The patient underwent a steroid treatment. No further episodes of functional intestinal obstruction were observed and, after an initial improvement, the neurological symptoms stabilized, leaving a permanent reduction in hearing function and an unsteady gait. The case shows that an idiopathic inflammatory insult of the myenteric plexus may precede (and perhaps lead to) central nervous system impairment in patients with anti-Hu-associated chronic idiopathic intestinal pseudo-obstruction.
 ...
PMID:Cerebellar degeneration and hearing loss in a patient with idiopathic myenteric ganglionitis. 1575 99

Colonic metastasis of the bronchogenic carcinoma is quite rare. Here we document an extremely rare presentation of the lung cancer that presented with acute abdomen and was diagnosed as intestinal obstruction due to colon carcinoma initially. He underwent an urgent operation and the obliterating mass in the colon was resected and reported as "colon metastasis from epidermoid carcinoma probably of the lung". Afterwards bronchoscopy revealed an endobronchial lesion in the right lower lobe that was diagnosed as poorly differentiated squamous cell lung carcinoma. In this case, colon metastasis was diagnosed before the diagnosis of the primary disease.
 ...
PMID:A case of bronchogenic carcinoma presenting with acute abdomen. 1625 89

A CT scan of a 69-year-old male patient, performed for staging of suspected lung carcinoma, incidentally showed an irregular lesion of 10 cm in the upper abdomen. Further investigation using FDG-PET showed only moderately increased glucose metabolism, whereas Tc-99m MDP SPECT revealed intense osteoblastic activity inside the lesion. A CT-guided biopsy was performed and histologic analysis established the diagnosis of heterotopic mesenteric ossification. This pathology is rare and mostly diagnosed when it is complicated by small bowel obstruction.
 ...
PMID:Imaging characteristics of heterotopic mesenteric ossification on FDG PET and Tc-99m bone SPECT. 1858 Feb 41

Metastatic squamous cell carcinoma in the pyloroduodenal region is uncommon. Cases have been reported where carcinoma of the lung has presented with metastasis to the duodenum. We present here the case of a 57-year-old lady who was found to have a metastasis in pyloroduodenal region while on treatment for carcinoma cervix. The patient developed features of intestinal obstruction and endoscopy showed a growth extending from pyloric antrum to first part of duodenum up to the junction of first and second part. A biopsy was taken from the duodenal area and it was reported as metastatic squamous cell carcinoma. This is one of the few reported cases of hematogenous visceral metastasis from carcinoma cervix. Since the disease was found to be advanced and her performance status was poor, she was provided best supportive care.
 ...
PMID:Squamous cell carcinoma cervix with metastasis to pyloroduodenal region. 2176 8

Intestinal metastases from lung cancer are exceptional and even more rare is their manifestation before the primary tumor. The clinical manifestation may require surgical resection because of intestinal perforation, hemorrhage, intestinal obstruction or partial blockage as in the case that we report. Survival in the few cases reported, is low and generally does not exceed 20 weeks, regardless of the treatment performed. We report the case of a jejuno-jejunal intussusception manifested by occlusive syndrome and gastrointestinal bleeding due to the metastasis of an adenosquamous lung carcinoma.
 ...
PMID:[Jejuno-jejunal intussusception as presentation of a primary lung carcinoma: a case report]. 2261 98

Intussusception is a rare form of intestinal obstruction in adults. Most cases are caused by malignant lesions in the intestinal wall, which in exceptional cases are caused by metastases. The initial manifestation of lung cancer as metastasis to the gastrointestinal tract is an extremely rare event. In most cases metastases are diagnosed after the primary lung tumour, when potentially life-threatening complications such as perforation, obstruction or haemorrhage develop, often requiring emergency surgery. Regardless of treatment, these patients have very poor prognosis due to the advanced stage of their disease. The study describes the case of a 48-year-old man presenting at the emergency department with a bowel obstruction of a week's duration, who was diagnosed via CT scan with small-bowel intussusception, and via chest x-ray with a suspicious lung nodule. Emergency surgery was performed, with intestinal resection of the invaginated area and anastomosis. Postoperative recovery was uneventful. The histopathological diagnosis was intestinal metastasis from lung carcinoma. Stage IV primary malignant lung tumour was confirmed, with spread through the lungs, bones, brain and metastases in both adrenal glands. Received palliative treatment with radiation and chemotherapy, and died five months after diagnosis.
 ...
PMID:[Intestinal intussusception as the first manifestation of lung cancer]. 2518 89

Small intestinal metastasis from primary lung carcinoma is infrequent and seen at the terminal stage of the disease as the first sign. These patients are often present as perforation and peritonitis but rarely with small bowel obstruction. We reported a case of a 61-year-old man who was admitted to our hospital with acute abdominal pain. Abdominal X-ray manifested an acute ileus. Ileoileal resection-anastomosis was performed after removal of two separate tumors in the small intestine. Histopathological result indicated metastatic adenocarcinoma. The patient had not been diagnosed as any carcinoma or lung disease previously. The postoperative thorax computed tomography scan showed a lesion at the right lung, which was pathologically defined as adenocarcinoma of the lung by bronchial brushing. This case is reported to arouse a clinical suspicion of intestinal metastasis in undiagnosed primary lung cancer presenting with acute abdominal pain. Early diagnosis and treatments are vital for improving survival of the patients.
...
PMID:Undiagnosed primary lung carcinoma with initial manifestation of intestinal obstruction: A case report and literature review. 2632 14


1 2 Next >>