Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0677930 (primary tumor)
20,210 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1191
nodal 801
Mol 715
p53 584
osteosarcoma 341
estrogen receptor 298
FDG 294
TNM 284
epidermal growth factor receptor 282
HER2 267
MRI 259
cytokine 208
She 204
vascular endothelial growth factor 199
E-cadherin 196
vimentin 192
collagen 180
CD8 179
progesterone receptor 176
cytokeratin 171
Ki-67 167
EGFR 165
carcinoembryonic antigen 162
rhabdomyosarcoma 157
KRAS 150
cage 145
BRAF 144
tyrosine kinase 141
interferon 136
CD44 129
CEA 119
VEGF 109
somatostatin 108
AKT 102
colon carcinoma 102
lymphoid 101
p16 98
hormone receptor 95
CXCR4 93
catenin 91
more...
Disease
primary tumor 20210
tumor 12798
cancer 9003
metastases 7239
carcinoma 2796
breast cancer 2504
melanoma 1270
adenocarcinoma 1263
tumor growth 1043
squamous cell carcinoma 959
tumor progression 935
colorectal cancer 831
lung cancer 745
liver metastases 599
lung metastases 566
prostate cancer 541
lung carcinoma 516
gastric cancer 501
renal cell carcinoma 477
sarcoma 476
tumorigenesis 439
osteosarcoma 426
hepatocellular carcinoma 371
neuroblastoma 352
non-small cell lung cancer 350
colon cancer 325
lymphoma 314
carcinogenesis 313
metastatic breast cancer 294
residual disease 278
bone metastases 247
brain metastases 235
ovarian cancer 225
pancreatic cancer 222
glioma 201
carcinoid 199
head and neck cancer 190
rectal cancer 187
rhabdomyosarcoma 180
glioblastoma 169
more...
Symptom
pain 276
abdominal pain 114
diarrhea 94
dyspnea 70
headache 67
vomiting 67
anesthesia 64
nausea 63
anorexia 53
fatigue 52
cough 48
weakness 43
seizures 34
nausea and vomiting 31
discomfort 28
discomfort 28
epigastric pain 28
bone pain 26
back pain 25
ENT 24
chest pain 22
hemoptysis 19
cachexia 19
constipation 16
splenomegaly 15
ataxia 15
flushing 14
respiratory distress 14
flank pain 14
hepatomegaly 13
dizziness 13
Sister Mary Joseph's nodule 13
collapse 12
shortness of breath 12
paresis 12
numbness 11
paresthesia 11
cancer pain 10
Ill 9
syncope 9
more...
Drug
Dermatol 158
Cardiovasc 108
Adriamycin 74
IL-2 71
CSF 61
IFN-gamma 59
CTX 50
ENT 41
CPT-11 29
uPA 27
Herceptin 26
Monit 25
HCG 23
Paraffin 23
Imatinib 20
Docetaxel 20
lysine 19
PTC 19
MAP 18
Bevacizumab 18
Taxol 17
MTC 16
ADM 16
ROC 16
CTX 15
CTX 15
Gleevec 14
CTC 13
CTC 13
Lipiodol 13
CAM 12
Leucovorin 12
ROS 12
Leaf 12
MDS 11
GEO 10
Indomethacin 10
VCR 9
Meth 9
ABC 9
more...
Enzyme
ERK 709
mitogen-activated protein kinase 152
focal adhesion kinase 142
luciferase 93
urokinase-type plasminogen activator 76
protein kinase 65
alkaline phosphatase 62
lactate dehydrogenase 54
reverse transcriptase 53
MEK 52
ACS 52
caspase-3 51
prostate-specific antigen 42
APC 41
collagenase 37
prostate-specific membrane antigen 30
peroxidase 29
acid phosphatase 25
matrix metalloproteinase 2 23
CD10 22
MMP 22
thrombin 20
MDP 20
PARP 20
proteasome 20
thymidylate synthase 19
matrix metalloproteinase 9 19
thymidine kinase 18
protein kinase C 17
trypsin 17
plasmin 17
beta-galactosidase 16
tyrosinase 16
cdc2 15
phosphatidylinositol 3-kinase 15
aldehyde dehydrogenase 15
cathepsin D 15
topoisomerase 15
catalase 15
aldehyde dehydrogenase 14
more...
Compound
Clin 1558
Dec 1372
DNA 1124
TNM 284
MDA 215
5-FU 133
oxygen 129
glucose 118
tyrosine 98
calcium 98
Adriamycin 90
iodine 76
methionine 70
water 68
His 57
ACS 52
arginine 51
ACS 51
CTX 50
acetate 50
DDP 50
galactose 49
sulfate 47
phosphate 47
MTT 45
fluorine 42
serine 42
TNF 42
nitric oxide 41
Thyroid 40
PEG 39
sodium 39
Estrogen 38
SCC 38
MEK 38
barium 37
BCG 36
iron 36
Estrogen 35
VP-16 34
more...