Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1191
nodal 801
Mol 715
p53 584
osteosarcoma 341
estrogen receptor 298
FDG 294
TNM 284
epidermal growth factor receptor 282
HER2 267
MRI 259
cytokine 208
She 204
vascular endothelial growth factor 199
E-cadherin 196
vimentin 192
collagen 180
CD8 179
progesterone receptor 176
cytokeratin 171
Ki-67 167
EGFR 165
carcinoembryonic antigen 162
rhabdomyosarcoma 157
KRAS 150
cage 145
BRAF 144
tyrosine kinase 141
interferon 136
CD44 129
CEA 119
VEGF 109
somatostatin 108
colon carcinoma 102
AKT 102
lymphoid 101
p16 98
hormone receptor 95
CXCR4 93
catenin 91
CD4 89
matrix metalloproteinase 88
chemokine 87
PI3K 84
fibronectin 84
PIK3CA 81
IFN 80
erbB-2 78
mTOR 77
MMP-9 76
Bcl-2 76
mucin 74
PTEN 73
urokinase-type plasminogen activator 72
CD34 72
CXCL12 70
ras 69
IL-2 69
Pol 68
PD-L1 68
alpha-fetoprotein 68
neu 67
IL-6 66
MAPK 65
tumor necrosis factor 65
CK20 65
desmin 64
MMP-2 64
epidermal growth factor 63
androgen receptor 63
alkaline phosphatase 62
caspase-3 62
synaptophysin 61
PD-1 61
IFN-gamma 60
c-myc 59
neuron-specific enolase 58
metastasis suppressor 58
p21 58
reserved 57
ERK 57
CDKN2A 56
KIT 56
insulin 52
keratin 52
ACS 51
BRCA1 51
cyclin D1 50
proto-oncogene 49
CD133 49
receptor tyrosine kinase 49
CD31 48
glycoprotein 47
calcitonin 47
thyroglobulin 47
chromogranin A 47
FISH 46
prostate-specific antigen 46
somatostatin receptor 45
N-cadherin 45
S100 45
interleukin-2 45
IL-8 44
lactate dehydrogenase 44
TNF 42
MYCN 42
F10 42
NRAS 41
non-Hodgkin's lymphoma 41
HLA 40
APC 40
CSF 40
polypeptide 40
thymus 40
ERBB2 40
smooth muscle actin 39
chorionic gonadotropin 39
EGF 39
hepatocyte growth factor 39
proliferating cell nuclear antigen 39
MEK 39
CK7 39
SCC 38
STAT3 38
histone 38
pT1 38
pT3 38
PC-3 38
RB1 37
CDK4 37
ERK1 36
K-ras 36
TGF-beta 36
MDM2 36
N-myc 36
beta-catenin 36
c-kit 36
NOD 36
interferon-gamma 35
MHC 35
CD117 35
MET 35
p27 34
nm23 34
bcl-2 33
CD20 33
focal adhesion kinase 33
fused 33
plasminogen activator inhibitor-1 33
EMT 33
PSA 33
VEGFR2 32
CD24 32
osteopontin 32
CD56 32
MIB 32
plasminogen 32
cell adhesion molecule 31
IL-10 31
ATP 31
more...
Disease
primary tumor 20210
tumor 12798
cancer 9003
metastases 7239
carcinoma 2796
breast cancer 2504
melanoma 1270
adenocarcinoma 1263
tumor growth 1043
squamous cell carcinoma 959
tumor progression 935
colorectal cancer 831
lung cancer 745
liver metastases 599
lung metastases 566
prostate cancer 541
lung carcinoma 516
gastric cancer 501
renal cell carcinoma 477
sarcoma 476
tumorigenesis 439
osteosarcoma 426
hepatocellular carcinoma 371
neuroblastoma 352
non-small cell lung cancer 350
colon cancer 325
lymphoma 314
carcinogenesis 313
metastatic breast cancer 294
residual disease 278
bone metastases 247
brain metastases 235
ovarian cancer 225
pancreatic cancer 222
glioma 201
carcinoid 199
head and neck cancer 190
rectal cancer 187
rhabdomyosarcoma 180
aggressiveness 169
glioblastoma 169
esophageal cancer 165
mammary tumor 161
esophageal cancer 158
leukemia 155
lymphadenopathy 155
epithelial ovarian cancer 153
solid tumor 142
bladder cancer 142
Ewing's sarcoma 142
brain tumor 125
cutaneous melanoma 124
cervical cancer 121
Melanoma 120
metastatic melanoma 119
fibrosarcoma 117
SCID 115
thyroid cancer 114
small cell lung cancer 113
tumor angiogenesis 109
neuroendocrine tumor 106
WT1 106
carcinomatosis 99
glioblastoma multiforme 98
endometrial cancer 91
Hodgkin's disease 90
bronchogenic carcinoma 89
teratoma 89
leiomyosarcoma 87
lymphatic vessels 87
MCF 86
Osteosarcoma 83
Osteosarcoma 83
aggression 83
anemia 82
systemic disease 81
meningioma 81
metastatic renal cell carcinoma 80
multiple myeloma 79
adenoma 79
ductal carcinoma 77
medulloblastoma 76
malignant fibrous histiocytoma 76
uterus 75
Merkel cell carcinoma 72
gastrointestinal stromal tumor 72
angiosarcoma 71
renal cancer 71
Hepatocellular carcinoma 66
Dukes 65
mesothelioma 64
uveal melanoma 64
germ cell tumor 64
liposarcoma 62
retinoblastoma 62
stromal tumors 61
skin cancer 61
Neuroblastoma 60
laryngeal cancer 60
hypercalcemia 60
Neuroblastoma 60
paraneoplastic syndrome 59
transitional cell carcinoma 59
neutropenia 58
chondrosarcoma 58
laryngeal cancer 58
seminoma 57
epithelial tumor 57
carcinoma of the breast 56
synovial sarcoma 55
pheochromocytoma 55
carcinoid syndrome 55
non-Hodgkin's lymphoma 55
B-cell lymphoma 55
neuroendocrine carcinoma 54
uterine cervix 54
CUP 54
Glioblastoma 54
pneumonia 53
Esophageal 53
Epstein 53
oral cancer 53
carcinoma of the breast 52
astrocytoma 51
acute myeloid leukemia 51
papillary thyroid cancer 51
hypertension 51
thrombocytopenia 51
testicular cancer 50
minimal residual disease 50
dysplasia 50
bowel obstruction 49
liver cancer 49
carcinoma in situ 49
medullary thyroid carcinoma 49
dysphagia 49
prostatic adenocarcinoma 48
ductal carcinoma in situ 47
leukopenia 47
mole 47
Rhabdomyosarcoma 45
tumor initiation 45
Colon 45
Colon 45
Colon 45
paraganglioma 45
embryonal carcinoma 44
rare disease 42
Gastric Cancer 42
malignant mesothelioma 42
APC 41
diabetes 41
adrenocortical carcinoma 40
HCG 40
cirrhosis 39
carcinosarcoma 39
choriocarcinoma 39
residual cancer 39
invasive cancer 38
liver disease 38
more...
Symptom
pain 276
abdominal pain 114
diarrhea 94
dyspnea 70
headache 67
vomiting 67
anesthesia 64
nausea 63
anorexia 53
fatigue 52
cough 48
weakness 43
seizures 34
nausea and vomiting 31
discomfort 28
discomfort 28
epigastric pain 28
bone pain 26
back pain 25
ENT 24
chest pain 22
cachexia 19
hemoptysis 19
constipation 16
splenomegaly 15
ataxia 15
respiratory distress 14
flank pain 14
flushing 14
Sister Mary Joseph's nodule 13
hepatomegaly 13
dizziness 13
collapse 12
shortness of breath 12
paresis 12
numbness 11
paresthesia 11
cancer pain 10
analgesia 9
asthenia 9
syncope 9
hoarseness 9
Ill 9
dysuria 9
low back pain 8
hypothermia 8
exhaustion 8
exertional dyspnea 8
overweight 7
abdominal fullness 7
erythema 7
myoclonus 7
starvation 7
blurred vision 6
acidity 6
masculinization 6
dysarthria 6
regurgitation 5
tremor 5
hemiplegia 5
colic 5
neck stiffness 5
lethargy 5
angina 5
pelvic pain 5
right upper quadrant pain 4
polyuria 4
tinnitus 4
sore throat 4
vertigo 4
chills 4
neck pain 4
urinary frequency 4
abdominal discomfort 4
anal pain 4
hip pain 4
otalgia 4
facial pain 3
arthralgia 3
myalgia 3
shoulder pain 3
wheezing 3
distraction 3
cerebellar ataxia 3
bloating 3
leg pain 3
pallor 3
chronic cough 3
cyanosis 3
forgetfulness 3
leg edema 3
functional recovery 3
emaciation 2
testicular pain 2
fever of unknown origin 2
memory loss 2
heartburn 2
menometrorrhagia 2
dyschezia 2
night sweats 2
sciatica 2
polydipsia 2
acute abdomen 2
tenesmus 2
epigastric distress 2
renal colic 2
ophthalmoplegia 2
stomach pain 2
decreased appetite 2
hot flushes 2
dysesthesia 2
nipple discharge 2
lassitude 2
clubbing 2
lump in the neck 2
nipple discharge 2
penile lesion 2
sleepiness 2
intestinal bleeding 2
Overlying 2
bradykinesia 1
anosmia 1
productive cough 1
enuresis 1
chyluria 1
abnormal gait 1
HSA 1
Spots 1
neuralgia 1
Spotting 1
knee pain 1
tingling 1
dental pain 1
Severe diarrhea 1
acute abdominal pain 1
Foot pain 1
Neuropathic pain 1
halitosis 1
prostration 1
frequent urination 1
rales 1
hyperoxia 1
hepatosplenomegaly 1
finger pain 1
dry eye 1
inanition 1
heel pain 1
peau d'orange 1
atypical chest pain 1
acute pain 1
McBurney's point 1
thigh pain 1
General symptoms 1
Cushingoid 1
Signs and Symptoms 1
diminished hearing 1
Scratch 1
orthopnea 1
CSR 1
giddiness 1
more...
Drug
Dermatol 158
Cardiovasc 108
Adriamycin 74
IL-2 71
CSF 61
IFN-gamma 59
CTX 50
ENT 41
CPT-11 29
uPA 27
Herceptin 26
Monit 25
Paraffin 23
HCG 23
Imatinib 20
Docetaxel 20
PTC 19
lysine 19
Bevacizumab 18
MAP 18
Taxol 17
ROC 16
ADM 16
MTC 16
CTX 15
CTX 15
Gleevec 14
CTC 13
Lipiodol 13
CTC 13
CAM 12
ROS 12
Leaf 12
Leucovorin 12
MDS 11
GEO 10
Indomethacin 10
ABC 9
VCR 9
Meth 9
Portal 8
PTH 8
ADR 8
Sorafenib 8
ETS 8
CDP 7
Mutagen 7
ACT 6
VCR 6
Bortezomib 6
ALA 6
RFP 6
vitamin E 6
TAC 6
Gel 6
Etoposide 6
Cetuximab 6
Taxotere 6
Fulvestrant 5
CDX 5
Zoledronic acid 5
Erlotinib 5
Zoledronic acid 5
Gelfoam 5
Everolimus 5
ascorbate 5
CDX 5
OctreoScan 5
R1881 4
Urokinase 4
CPM 4
Sandostatin 4
DMSA 4
caffeine 4
NVP 4
G-CSF 4
Sandostatin 4
PDL 4
Histamine 4
Asn 4
Gefitinib 4
DNase I 4
Oxaliplatin 4
Vinorelbine 4
Irinotecan 4
Norplant 3
Zoladex 3
G418 3
lactose 3
Itraconazole 3
Zoladex 3
Rosiglitazone 3
Activin 3
Sunitinib malate 3
Lovastatin 3
CSI 3
MRC 3
THF 3
Gastro 3
Nitric Oxide 3
Vorinostat 3
Ranitidine 3
Nephron 3
DM1 2
Xeloda 2
Thyroglobulin 2
Batimastat 2
Denosumab 2
Pemetrexed 2
Glucagon 2
Ipilimumab 2
TTC 2
Vindesine 2
Vindesine 2
EE2 2
Navelbine 2
Alanine 2
Sandostatin LAR 2
Batimastat 2
Casodex 2
Vicryl 2
IFN-beta 2
ProstaScint 2
Heme 2
Diamminedichloroplatinum 2
CEA-Scan 2
BLM 2
Nephron 2
Nexavar 2
Angiotensin II 2
nitroglycerin 2
Panitumumab 2
Amiloride 2
Maraviroc 2
Dexrazoxane 2
Fluorescein 2
Trabectedin 2
ICI 2
KGF 2
DFP 2
Mitomycin-C 2
Isosulfan blue 2
TAT 2
ETA 2
Swainsonine 2
Iloprost 2
MOF 2
CCL 2
KAN 2
Dexon 1
Optison 1
Methylprednisolone 1
Emodin 1
Glutathione 1
citric acid 1
LMWH 1
MDM 1
DEL 1
Triad 1
DEX 1
more...
Enzyme
ERK 709
mitogen-activated protein kinase 152
focal adhesion kinase 142
luciferase 93
urokinase-type plasminogen activator 76
protein kinase 65
alkaline phosphatase 62
lactate dehydrogenase 54
reverse transcriptase 53
ACS 52
MEK 52
caspase-3 51
prostate-specific antigen 42
APC 41
collagenase 37
prostate-specific membrane antigen 30
peroxidase 29
acid phosphatase 25
matrix metalloproteinase 2 23
MMP 22
CD10 22
thrombin 20
MDP 20
PARP 20
proteasome 20
thymidylate synthase 19
matrix metalloproteinase 9 19
thymidine kinase 18
plasmin 17
protein kinase C 17
trypsin 17
tyrosinase 16
beta-galactosidase 16
cdc2 15
phosphatidylinositol 3-kinase 15
cathepsin D 15
catalase 15
aldehyde dehydrogenase 15
topoisomerase 15
aldehyde dehydrogenase 14
topoisomerase 14
aldehyde dehydrogenase 14
RNA polymerase 14
aldehyde dehydrogenase 14
aldehyde dehydrogenase 14
granzyme B 13
firefly luciferase 13
enolase 13
ALDH 13
lysozyme 13
P-glycoprotein 13
caspase-8 12
dihydropyrimidine dehydrogenase 12
RNase 11
glutathione S-transferase 11
lysyl oxidase 11
RNase 11
transcriptase 11
gamma-glutamyl transpeptidase 10
phosphoinositide 3-kinase 10
carbonic anhydrase 10
DNA methyltransferase 10
GSK 10
DCF 10
AMP-activated protein kinase 9
MAT 9
cathepsin B 9
isocitrate dehydrogenase 9
MAT 9
isocitrate dehydrogenase 9
NOS 8
ATPase 8
dihydropyrimidine dehydrogenase 8
aspartate aminotransferase 8
IKK 8
indoleamine 2,3-dioxygenase 8
endonuclease 8
tryptase 8
SST 7
MIP 7
MMP-3 7
calcineurin 7
alanine aminotransferase 7
adenosine deaminase 7
tyrosine hydroxylase 7
adenosine deaminase 7
succinate dehydrogenase 7
arginase 6
CGT 6
chymotrypsin 6
neutrophil elastase 6
adenylate cyclase 6
MAP 6
glyceraldehyde-3-phosphate dehydrogenase 5
hexokinase 5
proprotein convertase 5
STK11 5
caspase-9 5
tissue plasminogen activator 5
phosphoglucose isomerase 5
CPT 5
diamine oxidase 5
demethylase 5
alcohol dehydrogenase 5
thymidine phosphorylase 5
CPT 5
ACE 5
neuraminidase 5
CPT 5
CD13 5
thromboplastin 4
dihydrofolate reductase 4
ATP synthase 4
DNase 4
phospholipase A2 4
ribonucleotide reductase 4
ribonucleotide reductase 4
TSP-1 4
ornithine decarboxylase 4
sialyltransferase 4
sialyltransferase 4
sialyltransferase 4
legumain 4
AMPK 4
renin 4
BMA 4
cytidine deaminase 4
5'-nucleotidase 4
CPM 4
AMPK 4
phosphodiesterase 4
sialidase 3
S-adenosylmethionine decarboxylase 3
MTD 3
soluble epoxide hydrolase 3
ribonuclease 3
lipase 3
histidine kinase 3
ADH 3
furin 3
monoamine oxidase 3
mannosidase II 3
caspase-1 3
carboxylesterase 3
NO synthase 3
Thy1 3
TOR 3
MDR 3
cathepsin L 3
methylthioadenosine phosphorylase 3
elastase 3
DNA ligase 3
pepsin 3
N-acetyltransferase 3
DNA ligase 3
AST 3
cytosine deaminase 3
phospholipase D 3
sulfatase 3
papain 3
more...
Compound
Clin 1558
Dec 1372
DNA 1124
TNM 284
MDA 215
5-FU 133
oxygen 129
glucose 118
calcium 98
tyrosine 98
Adriamycin 90
iodine 76
methionine 70
water 68
His 57
ACS 52
arginine 51
ACS 51
acetate 50
DDP 50
CTX 50
galactose 49
sulfate 47
phosphate 47
MTT 45
TNF 42
serine 42
fluorine 42
nitric oxide 41
Thyroid 40
PEG 39
sodium 39
SCC 38
MEK 38
Estrogen 38
barium 37
iron 36
BCG 36
Estrogen 35
Optimal 34
VP-16 34
DBA 32
formaldehyde 32
ATP 31
Vimentin 31
retinoic acid 30
Methotrexate 30
PEG 30
cysteine 30
lysine 29
CPT-11 29
leucine 28
DTPA 28
ASA 27
Gly 27
ACTH 27
Asp 26
ADR 26
Phe 25
DBA 25
DBA 25
cobalt 24
hyaluronic acid 24
Paclitaxel 23
MMC 23
DFS 22
CAM 22
DIC 20
ethanol 20
bromide 19
threonine 19
potassium 18
PMA 18
urea 18
CCNU 17
Tamoxifen 17
folinic acid 17
salt 17
zinc 17
Tamoxifen 17
MTX 17
Cardiol 17
MTC 16
nitrogen 16
creatinine 16
Gemcitabine 16
BCNU 16
Docetaxel 16
anthracene 16
Gemcitabine 16
silver 16
CBDCA 15
6-12 15
Pac 15
CBDCA 15
glutamine 15
A 71 14
A 42 14
boron 14
SDS 13
MCA 13
Progesterone 13
alanine 13
MCA 13
GTP 13
GM1 12
tryptophan 12
TSH 12
Luminal 12
Curcumin 12
copper 12
THP 11
DCC 11
AMP 11
CO2 11
VMA 11
Leucovorin 11
Vincristine 11
THP 11
vitamin D 11
glutamate 11
hydrogen 11
Androgen 11
pyrimidine 11
pyrimidine 11
CAT 10
CAP 10
tryptophan 10
cAMP 10
tryptophan 10
CAT 10
CAT 10
tryptophan 10
silicon 10
TPA 9
PGE2 9
Collagen 9
Octreotide 9
TPA 9
DMSO 9
PAS 9
NKT 9
MAP 9
PAP 8
Hematoxylin 8
PAP 8
Neo 8
PAP 8
dUTP 8
GSH 8
pyrene 8
PAP 8
aspartic acid 8
GSH 8
Adrenal 8
Ile 8
Insulin 8
BLM 8
valine 8
MIA 8
more...