Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0677930 (
primary tumor
)
20,210
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (
MAGI1
) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) patients' gene expression data, that
MAGI1
is highly expressed and acts as tumor suppressor in estrogen receptor (ER)
+
/HER2
-
but not in HER2
+
or triple negative breast cancer (TNBC). Within the ER
+
/HER2
-
subset, high
MAGI1
expression associates with ESR1 and luminal genes GATA3 and FOXA1 expression and better prognosis, while low
MAGI1
levels correlates with higher histological grade, more aggressive phenotype and worse prognosis. Experimentally,
MAGI1
downregulation in the ER
+
human BC cells MCF7 impairs ER expression and signaling, promotes cell proliferation, and reduces apoptosis and epithelial differentiation.
MAGI1
downregulation in the ER
+
murine BC cell line 67NR accelerates
primary tumor
growth and enhances experimental lung metastasis formation.
MAGI1
expression is upregulated by estrogen/ER, downregulated by prostaglandin E2/COX-2axis, and negatively correlates with inflammation in ER
+
/HER2
-
BC patients. Taken together, we show that
MAGI1
is a new potential tumor suppressor in ER
+
/HER2
-
breast cancer with possible prognostic value for the identification of patients at high-risk of relapse within this subset.
...
PMID:MAGI1, a New Potential Tumor Suppressor Gene in Estrogen Receptor Positive Breast Cancer. 3196 97
