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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The atrial myxoma is a primary tumor of the heart which may have an uncertain clinical course. In this study, we performed flow cytometric DNA analysis of 15 paraffin-embedded atrial myxomas and correlated DNA ploidy status and proliferative fraction with clinical findings. Twelve of 15 cases (80 percent) were diploid and the remaining three cases (20 percent) were aneuploid. Two patients with aneuploid histograms were free of tumor at the time follow-up; the third patient experienced local tumor recurrence and metastases. Five patients with diploid myxomas demonstrated an elevated (greater than or equal to 17 percent) proliferative cell cycle fraction; four of these patients experienced embolic phenomenon or tumor recurrence. This pilot study suggests that an atrial myxoma with either aneuploid DNA content or elevated proliferative fraction may be associated with aggressive biologic behavior.
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PMID:DNA analysis of atrial myxomas. 201 79

Using the prognostic value of morphometric and flow-cytometric features, a group of patients with invasive breast cancers detected with population screening (PS, n = 70) has been evaluated and compared with a random control group in 2 hospitals (H group, n = 225) diagnosed in the same period. The results show that the PS patients had smaller tumors, less positive lymph nodes, better differentiated tumors with a lower mitotic activity index (MAI) and lower values of the morphometric prognostic index (MPI). Furthermore, the women more frequently had diploid tumors and tumors with small nuclei. The second purpose was to evaluate whether quantitative microscopical features, in comparison with other prognostic features such as size of primary tumor, nodal status and histologic grade, are as strong prognosticators in PS tumors as in H-detected breast cancers. In comparison with H tumors, morphometric and flow-cytometric features, as well as tumor size, had the same prognostic value for the PS tumors. In contrast, nodal status was not significant within the PS group, and the same phenomenon was found in a subgroup of H patients with similar sized tumors. Of all quantitative microscopical features (MPI, MAI, mean nuclear area (MNA) and DNA Index (DI], the MAI had the strongest prognostic value. DI showed additional prognostic value to the MAI for patients with small tumors and with small tumor-cell nuclei, because a diploid pattern in these cases (this combination occurred in 21 patients of the total group = 30%) was correlated with a 95% 10-year survival rate. Histologic grade, although significant within the large H group, was of no prognostic value within the PS group, and also not as in the H sub-group with small tumors. It is concluded from morphometric and DNA flow-cytometric criteria that these prognostic features in invasive breast cancers detected by PS were all more favorable than in randomly detected hospital breast cancers. This may account for the reported better survival rate of PS patients. Furthermore, the prognosis of patients with small invasive breast cancers detected by population screening can be more accurately deduced by quantitative microscopical features than by axillary-lymph-node status.
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PMID:Prognostic value of morphometry and DNA flow-cytometry features of invasive breast cancers detected by population screening: comparison with control group of hospital patients. 201 64

Metastatic tumors in the brain, liver, and regional lymph nodes (20 cases each) from patients with adenocarcinoma of the lung were examined by cytofluorometric analysis, and compared with the respective primary lung tumors. The nuclear DNA content of tumor cells was significantly increased in metastatic tumors in the brain and liver compared with the primary (P less than 0.01). However, the DNA content of metastatic tumors in regional lymph nodes was almost identical to that of the primary tumor in many instances. From the viewpoint of the nuclear DNA content of lung adenocarcinoma, blood-borne tumor cells in the brain and liver were considered likely to constitute a discrete tumor cell subpopulation, i.e., probably a more malignant one, different from the major subpopulation in the primary tumor, whereas lymphatic metastases in regional lymph nodes were similar to the primary. The subpopulation with an increased DNA content in hematogenous metastases were thought to have originated from a minor subpopulation in the primary tumor or to have developed at the metastatic site.
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PMID:Cytofluorometric analysis of metastases from lung adenocarcinoma with special reference to the difference between hematogenous and lymphatic metastases. 202 61

This is a presentation of some preliminary data from SPCG-I, a multicenter study started in 1984 by the Scandinavian Prostatic Cancer Group. It is a randomized double-blind study comparing estramustine phosphate and diethylstilbestrol in the primary treatment of 195 patients with T1-4, NX, M1, G2-3 prostatic cancer. The code is not yet broken. This presentation describes the impact of the pretreatment parameters performance status, pain, tumor burden, grade and DNA-ploidy of the prostate tumor, on time to progression and overall survival. DNA studies have so far only been completed in 66 of the 195 patients. For the whole group of 195 patients, pain (p less than 0.004) and tumor grade (p less than 0.02) had the most significant impact on time to progression, and performance status (p less than 0.01) and grade (p less than 0.03) on overall survival. In the small group of 66 patients where the DNA pattern of the primary tumor was evaluated, no parameter had any significant correlation to time to progression and overall survival. This study is still continuing.
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PMID:DNA as a prognostic marker in advanced high-grade prostatic cancer. A preliminary report. SPCG-I study. 202 9

Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2/M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.
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PMID:DNA analysis of cardiac myxomas: flow cytometry and image analysis. 203 96

This study was designed to compare the prognostic potential of tumor grade and ploidy status in patients with stage D2 prostate cancer. Two outcome groups were selected on the basis of survival after orchiectomy: a bad outcome group consisting of 66 patients who died of the disease within 12 months and a good outcome group comprising 37 patients who survived beyond 5 years. Tumors were classified histologically as well (17%), moderately (17%) or poorly (66%) differentiated. Tumor grade was a significant predictor of outcome, with 76% of poorly differentiated tumors in the bad outcome group and 65% of well differentiated tumors in the good outcome group (p less than 0.005). Deoxyribonucleic acid (DNA) ploidy analysis was performed on formalin fixed, paraffin embedded samples of the primary tumor to yield 97 final tracings that were classified using set criteria for DNA ploidy status. Over-all, 54% of the tumors were nondiploid (33% aneuploid and 21% tetraploid) and the remaining 46% were diploid. DNA ploidy status was a significant indicator of outcome (p less than 0.001), with 64% of diploid tumors in the good outcome group and 88% of the nondiploid tumors in the poor outcome group. Tetraploid tumors behaved no differently from other nondiploid tumors. We conclude that DNA ploidy status and tumor grading are significant independent predictors of outcome after orchiectomy and when combined yield important additional prognostic information.
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PMID:The prognostic value of deoxyribonucleic acid flow cytometric analysis in stage D2 prostatic carcinoma. 203 91

The clinicopathologic and flow cytometric characteristics of 47 bronchopulmonary carcinoids were assessed, relative to patient survival. Aneuploidy was associated more often with tumor size of greater than or equal to 3.0 cm (P less than 0.004) and lymph node (P less than 0.013) or vascular involvement (P less than 0.004). Also, an aneuploid DNA content was seen significantly more often in histologically atypical (79%) than in typical carcinoid neoplasms (18%) (P less than 0.0001). Cox proportional hazard model analysis revealed that the histologic category (typical vs. atypical) and ploidy pattern were important prognostic indicators. Size of the primary tumor and the presence of vascular involvement were also significant predictors of outcome. Histologically atypical carcinoids with diploid DNA content pursued a less aggressive course than did their aneuploid counterparts.
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PMID:Typical and atypical bronchopulmonary carcinoids. A clinicopathologic and flow cytometric study. 204 93

Ten of 150 patients with primary squamous cell carcinoma of the esophagus and surgically treated, survived for more than 10 years. All 10 underwent a complete resection of the primary tumor and extensive lymph node dissection plus perioperative irradiation. The clinicopathologic findings in these 10 patients were reviewed. Five were female. Seven of the tumors exceeded 6 cm in length; seven were early stage, and the remaining three were advanced stage tumors. Lymph node metastases were evident in three, lymph vessel permeation was recognized in four, and no vascular vessel permeation was seen in any tumor. Two tumors had a characteristic appearance of carcinoma with lymphoid stroma, suggesting a good prognosis. In six for which cytophotometric DNA analysis could be done, four were type II, two were type III, and none was type IV. Thus, a complete resection of the primary tumor and extensive lymph node dissection can lead to a long survival time even for those with an advanced primary esophageal carcinoma.
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PMID:Ten-year survivors after surgical treatment and perioperative irradiation for esophageal carcinoma. 206 84

Growth and proliferation were studied of a transplantable mouse tumor, the adenocarcinoma EO 771 (Adca EO 771) growing in C 57 and in nude mice on the one hand, and of human tumors (renal cell and hypopharynx carcinoma) growing in nude mice on the other. There is almost no difference in tumor growth, histology and proliferation whether the Adca EO 771 grows in C 57 or in nude mice. However, there are great differences in this respect between the transplantable mouse tumor and human tumors. Growth of the Adca EO 771 and C 57 and in nude mice occurs according to the Gompertz function, whereas growth of human tumors in nude mice differs, some tumors grow exponentially and some according to the Gompertz function. The proportion of necrotic tissue strongly increases with increasing tumor size in the case of the Adca EO 771, while it is about constant in human tumors regardless of the tumor size. The tumor cell density of the Adca EO 771 increases considerably with increasing tumor size, however, it remains about constant in human tumors. Concerning tumor cell proliferation an S phase duration was found that is rather similar for the cells of the transplantable mouse tumor as well as of the human tumors suggesting that DNA synthesis might be regulated by the host organism. A quantitative study of the growth of the metastases of the Adca EO 771 exhibited an allometric correlation between the growth of the metastases and that of the primary tumor. This leads to the consequence that metastases might originate later than estimated until now assuming exponential growth of metastases. Treatment of the Adca EO 771 with cyclophosphamide results in the death of almost all tumor cells; however the tumor repopulates. The toxic effect of cyclophosphamide on the mouse organism strongly depends on the size of the tumor at the time of treatment.
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PMID:Growth and proliferation of a transplantable mouse tumor and of human tumors growing in nude mice. 208 Feb 96

In a prospective study 17 patients with oral PE carcinoma were given bolus injections of a non-toxic dose of BUdR, 4 hours prior to tumor surgery. BUdR replaces thymidine in the DNA of those cells which are in the S phase at the time of application. The resected tumor material was fixed in formalin and embedded in paraffin for immunohistochemical analysis using a monoclonal antibody against BUdR incorporated in DNA. The BUdR-storing cells were evaluated in 4 histologically different tumor areas. A total of 1600 cells was evaluated in each primary tumor or, in given cases, each lymph node metastasis or recurrence. In contrast to flow cytometry, this morphological method proved useful not only in comparing the number of BUdR-labelled cells with the total tumor cell population in different carcinoma segments, but also in correlating the focal proliferation tendency with the regional degree of differentiation and the number of mitotic cells even in morphologically different tissue segments. More often than not these results showed an increase in the average BUdR storage rate with increasing dedifferentiation and increasing rate of mitosis. Nevertheless, this is not the rule for each individual case. Some tumors displayed a relatively high proliferation tendency and BUdR storage rate in more highly differentiated areas (marked keratinization). Some poorly differentiated tumors or tumor areas, on the other hand, exhibited relatively low storage rates. Possibly, immunohistochemical analysis of a biopsy specimen after preoperative BUdR application may provide information on the radiosensitivity of the tumor.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Immunohistochemical results obtained with bromodeoxy uridine (BUdR) labelled tumors of the head and neck]. 210 12


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