Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0677930 (
primary tumor
)
20,210
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
MYO10
is an actin-based motor protein and correlates with cancer metastasis. However, the regulation of
MYO10
by tumor microenvironment is unknown. In the current study, we found that the expression of protease activated receptor 2 (PAR2) was highly correlated with that of
MYO10
in colorectal carcinoma (CRC) specimens. Both
MYO10
and PAR2 were up-regulated in lymph node metastasis group compared with non-metastasis group. Activation of PAR2 significantly induced cell migration through the up-regulation of
MYO10
, which was mediated by repression of miR-204 in multiple cell lines. Interestingly, it was observed that tryptase was highly expressed in adjacent tissue around
primary tumor
of CRC. Furthermore, tryptase stimulated cell migration and up-regulated
MYO10
expression through a PAR2-dependent manner. Taken together, our findings showed that PAR2 enhanced the expression of
MYO10
through the repression of miR-204. PAR2 mediated tryptase-induced cell migration and might contribute to the invasion of cancer cells at the edge of tumor.
...
PMID:Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer. 3159
