Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myxoma is the most common primary tumor of the heart. It is uncommon for these tumors to become infected and, at times, clinical presentation is no different from that of an uninfected myxoma. We describe the case of a 58-year-old woman with a previous pharyngeal infection that developed into infection of a left atrial myxoma and which was complicated by systemic embolism affecting the lower limbs. Streptococcus oralis was identified in blood cultures and embolic material. The tumor was resected and the patient's subsequent clinical evolution was uneventful. The incidence of infected myxoma is very low. A review of the literature based on individual case reports is presented.
Rev Esp Cardiol 2005 Nov
PMID:[Infected left atrial myxoma]. 1632 91

Papillary fibroelastoma is the third most common primary tumor of the heart and most commonly involve the cardiac valves. Most papillary fibroelastomas do not cause symptoms and they are usually incidental findings by routine echocardiography or at autopsy. However, multiple papillary fibroelastomas are extremely rare. We report a case with papillary fibroelastoma which was incidentally found on echocardiography. Upon surgery, a tumor was found on each aortic cusp. Pathological findings of these tumors were consistent with those of papillary fibroelastoma.
Int J Cardiol 2007 Oct 31
PMID:Multiple papillary fibroelastomas of the aortic valve: case report. 1719 73

We report the case of a 32-year-old patient with a left atrium myxosarcoma, presenting with congestive heart failure. It is a rare cardiac malignant primary tumor that seems to derive from the same cellular line as myxomas, but the prognosis is very different. These tumors present local recidives and distance metastasis, so the mean survival is about 1 year, independent of any therapeutical option.
Clin Cardiol 2007 Jun
PMID:Left atrium myxosarcoma: an exceptional cardiac malignant primary tumor. 1755 54

Primary cardiac tumors are very rare. Cardiac Papillary Fibroelastoma (CPF) is the third most common primary tumor of the heart and most commonly affects cardiac valves. Those tumors appear like a "sea anemone" with multiple papillary fronds attached to the endocardium by a short stalk. It generally occurs as a single structure and is typically found on the atrial aspect of atrioventricular valves or either side of the semilunar valves. We report a case of aortic valve papillary fibroelastoma which was found on autopsy in a patient with normal coronary artery with evidence of myocardial and cerebral ischemic damage and sudden death.
Int J Cardiol 2010 Feb 18
PMID:Cardiac Papillary Fibroelastoma: case report and review of the literature. 1871 82

Pheochromocytoma is a rare tumor, usually benign, potentially lethal in case of crisis with acute release of catecholamines. The heart is a target and the clinical presentation can mimic various cardiac conditions, thus rendering diagnosis elusive. Cardiac magnetic resonance is a valuable non-invasive diagnostic tool for the evaluation of cardiomyopathies; it allows the identification of catecholamine-induced myocarditis pattern and, in some cases, it can detect the primary tumor. The definitive treatment of pheochromocytoma is surgical, while the acute crisis may require mechanical support to circulation. We here report a case of pheochromocytoma in a 25-year-old man complicated by catecholamine-induced myocarditis and heart failure.
G Ital Cardiol (Rome) 2017 Feb
PMID:[Catecholamine-induced myocarditis in pheochromocytoma]. 2839 70

To date, there have been limited reports of oncogenesis occurring within pacemaker pockets. We report the case of a 100-year-old male who presented to the emergency department complaining of expansion of his pacemaker pocket over the period of 8 days. Dissection of the pacemaker pocket and pathological analysis of tissue samples revealed plasmablastic lymphoma, a subset of diffuse large B-cell lymphoma, commonly seen in immunocompromised elderly patients. This is the first known reported case of plasmablastic lymphoma occurring within a pacemaker pocket. <Learning objective: We describe the first case of a plasmablastic lymphoma arising as a primary tumor around a pacemaker site. A thorough literature review of primary tumors arising around pacemakers is provided. As the life expectancy of our population increases, the amount of time that pacemakers are in place increases as well. Therefore, we discuss several mechanisms that may have led to the oncogenicty of pacemakers, as well as the role of titanium in carcinogenesis.>.
J Cardiol Cases 2018 Feb
PMID:An enlarging pacemaker pocket: A case report of a plasmablastic lymphoma arising as a primary tumor around a cardiac pacemaker and systematic literature review of various malignancies arising at the pacemaker pocket. 3027 51

Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMT-MCT) causes tumor-induced osteomalacia (TIO). Most cases follow a benign clinical course, with rare occurrences of malignant transformation. We report a case of malignant PMT-MCT and review previous malignant cases to identify predictive factors for transformation. A 13-yr-old female, who presented with hypophosphatemic rickets, elevated serum intact fibroblast growth factor 23 (FGF23) levels, and a nodule in the back, received a diagnosis of TIO because of the benign PMT histopathology. After resection of the primary tumor, regular imaging analyses did not indicate any relapse. At 17 years of age, a tumor developed in the left leg and increased in size. The resected tumor showed a histopathology of pleomorphic sarcoma positive for the TP53 mutation. Despite amputation of the affected leg, the patient died due to multiple metastases at 18 years of age. A literature review revealed that 14 out of 15 reported malignant PMT-MCT tumors occurred in adults, and found no predictive factors for malignant transformation and treatment outcome. Changes in size or number of the tumors along with intact FGF23 levels have been considered as the only sign of malignant transformation. This pediatric case report and literature review indicate the need for prolonged regular monitoring for PMT-MCT.
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PMID:Malignant transformation of phosphaturic mesenchymal tumor: a case report and literature review. 3231 75


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