Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0677930 (
primary tumor
)
20,210
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hemostatic mechanisms play a role not only in cancer associated thrombotic diathesis, but also in tumor growth and dissemination. Hence, inhibition of fibrin formation has been considered a possible tool against the progression of malignant disease. An antineoplastic effect of antithrombotic agents in various experimental models (i.e. tumor cell in culture, experimental animals, and cancer patients) has often been suggested. Anticoagulant drugs such as heparins and vitamin K antagonists have been repeatedly tested in this context. However, heparins have been more extensively studied. Several reports in animal models demonstrate that heparin can reduce the
primary tumor
growth or its metastatic spread. Clinical studies of thrombosis in cancer patients show that, besides their role as antithrombotics, heparins may have beneficial effects on survival in these patients, with a major role for low molecular-weight heparin (LMWHs) compared to unfractionated heparin (UFH). More recently a number of prospective randomized clinical trials of
LMWH
for survival as a primary end-point in cancer patients have been conducted, showing favourable results.
...
PMID:Biological and clinical aspects of anticancer effects of antithrombotics. 1569 49
