Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The experience in the management of 246 patients with local osteogenic sarcoma and 67 patients with pulmonary metastases in the All-Union Oncologic Research Center, AMS USSR, is presented here. All the patients underwent surgery, but starting in 1974, various modalities of adjuvant chemotherapy (not randomized) were applied in addition. In the surgery alone group, prognosis was very poor: only 7.0% of patients survived free of disease 5 years from the primary tumor treatment. Adjuvant chemotherapy (adriamycin + vincristine + melphalan + cyclophosphamide) following amputations increased this rate to 34.0%; combining segmental resections of an affected bone with preoperative intraarterial adriamycin infusion and radiation (36 Gy) increased the rate to 35.5%. In patients with grade 4 tumor damage (tumor cells are not found upon examination of a large number of sections), the rate increased to 57.9% (P less than .05). Another regimen of adjuvant chemotherapy (platidiam or cisplatin + adriamycin + cyclophosphamide) gives a chance to 78.8% of patients to survive 1 year free of metastases. The same chemotherapy regimen enables us to achieve an objective effect in 30.8% of patients with pulmonary metastases, and its combination with surgical metastasis ablation makes it possible to obtain a complete remission, lasting from 2 to 46 months (average 13.9 months). Toxic manifestations of the chemotherapy regimens considered are moderate. Prognosis in adjuvant chemotherapy is related to age, tumor site, its local dissemination, and morphologic type of osteogenic sarcoma.
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PMID:Management of osteogenic sarcoma patients. 346

The paper is concerned with an analysis of the specificities of metastatic costal affection depending on the site of a primary tumor basing on a study of the skeleton scintigrams and scanograms of 2496 patients who were examined and treated in the All-Union Cancer Research Center, AMS USSR, in the period of 1980-1983. To assess the frequency of costal affection, the authors made use of an index of primary tumor metastasizing to the ribs (N. N. Trapeznikov, 1981) that reflects the ratio of the number of patients with costal metastases to the total number of patients with metastases. The analysis has shown that costal metastases are most frequently observed in breast carcinoma, prostatic and lung cancer. However, judging by the index of metastasizing tumors of the undetected primary focus come first, then head and neck tumors, and prostatic tumors. Costal metastases are observed 20% as more frequently in women than in men.
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PMID:[Characteristics of metastatic lesions of the ribs from various sites of primary tumor process]. 669 37