Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of stereotactically induced and spontaneously metastasizing neoplasms in the rat and the cat brain are reported. In the rat, a malignant Schwannoma derived from initially supratentorially implanted RN6 cells developed a second tumor in the posterior cranial fossa. In the cat, a highly malignant polymorphous anaplastic glioma induced by implantation of cloned rat glioma cells (F98) into the left internal capsule developed small tumor cell nests along the ependyma of the ipsilateral ventricle. In precontrast magnetic resonance imaging (MRI) of both cases, the primary tumor was detectable only by a very weak hypointensity and through a shift of the midline. No metastases were apparent. Application of the metallated paramagnetic porphyrin derivative manganese(III) tetraphenylporphine sulfonate (MnTPPS) resulted in a remarkable contrast enhancement between tumoral and normal tissue, which was evident not only in the primary tumor but also in the small metastases. These observations demonstrate for the first time that MnTPPS is an efficient MRI contrast agent for the detection of metastases from primary brain neoplasms and, in consequence, support the hypothesis of its selective binding to tumor cells.
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PMID:Identification of intracranial liqor metastases of experimental stereotactically implanted brain tumors by the tumor-selective MRI contrast agent MnTPPS. 150 24

Malignant schwannoma and peritoneal malignant mesothelioma (MM) are very rare tumors. Schwannoma or neurilemmoma-benign or malignant-do not arise from the nerves, but from the supporting Schwann cells. Malignant peripheral nerve sheath tumors (MPNSTs) commonly are large in size. They are painful and may cause many different symptoms depending on their location and size. MM arises primarily from the surface serosal cells of the pleural, peritoneal, and pericardial cavities. A malignant schwannoma was diagnosed in a 52-yearold woman, which was surgically treated. After a 17-month disease-free interval, local recurrence was diagnosed. The patient was operated on for second time and MM was diagnosed as second primary tumor, along with recurrence of the malignant schwannoma. The patient received postoperative adjuvant external beam radiotherapy and chemotherapy. Despite combined-modality treatment the disease progressed and the patient was operated on for third time 2.5 years after the first operation with partial tumor resection. She died 3 years after the first diagnosis. Early diagnosis of these two types of tumors is very difficult because of unspecific clinical symptoms. Singlemodality therapy of these tumors has shown poor results. Combined-modality approaches have shown some benefits, but further studies are required.
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PMID:Retroperitoneal malignant schwannoma and peritoneal malignant mesothelioma: a case report. 1738 35

Schwannoma is a rare primary tumor originating in the neural sheath with a good prognosis. The management is surgical. We present a case in which a retroperitoneal mass arising from the adrenal gland was excised and histopathology revealed a schwannoma with coexisting tuberculosis. This case report highlights the need to be aware of the potential coexistence of tuberculosis in any case of incidentaloma, especially due to resurgence of tuberculosis as a global epidemic with the increasing incidence of HIV and AIDS. To the best of our knowledge, this is the first reported case of a schwannoma and tuberculosis coexisting in the adrenal gland.
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PMID:Schwannoma with concomitant tuberculosis in the adrenal gland. 1971 6

Schwannoma is a usually benign primary tumor. It develops from the Schwann cells, which produce the myelin sheath that surrounds the peripheral nerves. It represents less than 10 % of the intracranial tumors, and it is infrequent in the pediatric age. We hereby present a 6-year-and-11-month-old previously healthy patient, with a history of intermittent generalized cephalea associated with proptosis and a diminished visual acuity of the left eye, epiphora and strabismus, with radiological evidence of retro-ocular mass. A macroscopically complete exeresis was performed, with an anatomopathological diagnosis of orbital schwannoma.
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PMID:[Orbital schwannoma in a child with acute proptosis]. 3267 97