Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Choriocarcinoma is a malignant germ cell tumor that usually arises from a previous gestation, but may also arise from germ cells anywhere along their known migratory pathway during fetal development. Gestational choriocarcinoma is highly sensitive to chemotherapy. This malignancy is known to undergo spontaneous regression of the primary tumor, which, in the face of metastases, may obscure the primary tumor site. The authors report the case of a patient with choriocarcinoma who was seen with pulmonary metastases and a single large lesion in the kidney 5 years posthysterectomy. The problems in resolving the primary site and the importance of a tissue diagnosis before nephrectomy are discussed.
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PMID:Choriocarcinoma of the kidney. 161 47

Choriocarcinoma is a malignant growth of trophoblastic cells characterized by the secretion of human chorionic gonadotropin. Primary choriocarcinoma arising in the placenta during a seemingly normal gestation is rare. Very few choriocarcinomas occurring simultaneously in mother and child have been reported so far. We describe an additional case of placental choriocarcinoma metastasizing to the newborn and showing many different cutaneous tumors. The primary tumor was found in the placenta. In the newborn, diagnosis was performed by skin biopsy only a few days after birth (by optic and electron microscopy). Immunohistochemical localization of human chorionic gonadotropin was performed by the immunoperoxidase technic with the use of monoclonal antibodies. This report describes an additional case and summarizes previously reported cases of placental choriocarcinoma metastasizing to the infant, as well as cases of skin metastases from malignant gestational trophoblastic disease.
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PMID:Infantile choriocarcinoma with cutaneous tumors. An additional case and review of the literature. 371 1

Choriocarcinoma was found in the lung of a 34-year-old woman. Examination of the patient's entire body, especially the genital tract, failed to disclose foci of choriocarcinoma other than that in the right lung. After surgery, the levels of human chorionic gonadotropin in the blood and the urine fell. It was concluded that the choriocarcinoma of the lung was, in fact, the primary tumor. The genesis of choriocarcinoma was also studied in ten patients who died after delivery or abortion. Autopsy disclosed trophoblasts in the pulmonary arteries in nine of these ten patients. These findings suggest that primary choriocarcinoma in women is due to pulmonary embolism caused by trophoblasts at the time of abortion or delivery.
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PMID:Primary choriocarcinoma of the lung. 384 Jul 68

Choriocarcinoma most commonly occurs within the uterine corpus. Just as placental implantation rarely occurs in the cervix, choriocarcinoma of the cervix is unusual. A case is presented of a 35-year old white woman, para 1-0-0-1 who had an uneventful term pregnancy 1 year prior to admission. She used an IUD and reported regular menses until 3 months prior to admission when she noted irregular bleeding. At initial examination a serum pregnancy test was positive, indicating a mass thought to be a cervical leiomyoma and bilateral cystic ovaries. Pathologic interpretation of an endocervical curettage was choriocarcinoma. At that point a hysterectomy was performed; there were no further complications and the patient subsequently received 3 additional courses of methotrexate. Cervical choriocarcionoma may develop from cervical metastases from a primary tumor in the corpus which later spontaneously regresses, malignant transformation of a cervical pregnancy, or transport of chorionic cells from a preceding pregnancy that undergo malignant transformations after a dormant period. In the nulliparous patient the conservation of reproductive function should be considered if possible.
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PMID:Cervical choriocarcinoma associated with an intrauterine contraceptive device: a case report. 668 83

The authors describe a case of Cor Pulmonale due to Tumor Cell Embolization in a 42-year-old woman with no history of antecedent malignant disease. The primary tumor was a Choriocarcinoma which could not be found in postmortem examination. The pathophysiology, clinical manifestations and diagnostic evaluation of this entity are briefly discussed.
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PMID:[Cor pulmonale caused by neoplasm cell embolism]. 837 52

BACKGROUND Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal choriocarcinoma is exceptionally rare and few cases have been described in the literature. CASE REPORT We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. She was found to have a brain mass, which was excised by neurosurgery and found to be a choriocarcinoma. She was then started on standard first-line therapy of EMACO, but was subsequently lost to follow-up. CONCLUSIONS Postmenopausal choriocarcinoma is rare and there are few case reports in the literature. It is a rare but possibly under-diagnosed metastatic disease in women. At present, a postmenopausal woman without a clear primary tumor should have a pregnancy test performed to rule out choriocarcinoma, as it is readily responsive to therapy.
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PMID:Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report. 3198 28