Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To our knowledge, esophageal carcinoma that is metastatic to the gastric cardia has rarely been described in the radiologic literature. We examined seven patients who had a solitary metastasis in the gastric cardia that had spread from esophageal carcinoma. Five of the gastric lesions were synchronous with the primary lesion, and two developed after the primary tumor had been detected. Radiographically, the gastric lesion appeared as a submucosal mass in five patients and appeared to simulate a primary gastric carcinoma in the other two patients. The metastases had probably disseminated through the submucosal lymphatic system. Because the presence of a gastric metastasis may affect a patient's therapy, radiographic examination of the gastric fundus should be a routine part of the initial staging and/or follow-up evaluation of esophageal carcinoma.
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PMID:Gastric cardia metastasis in esophageal carcinoma. 373 1

A case of an adolescent girl with metastatic gastric stromal tumor is described. There were three metastatic nodules in the liver at the time of the admission. A subtotal gastrectomy was performed. The tumor had distinctly nodular appearance and was composed of a variety of cells suggestive of smooth muscle differentiation. Electron microscopy revealed cytoplasmic neural processes and densecore neurosecretory granules. Immunohistochemistry showed positive neuron-specific enolase, synaptophysin, and chromogranin A in some of the tumor cells. Similar findings in the primary tumor and its liver metastases indicated a primitive neural differentiation and enabled us to classify the lesion as a gastric autonomic nerve tumor. No other tumors that would suggest that the gastric lesion is a part of Carney's triad were detected. The child was treated with chemotherapy but the liver metastases did not change significantly. She is alive with unresectable liver metastases 10 months after the gastrectomy.
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PMID:Gastrointestinal autonomic nerve tumor: a case report with electron microscopic and immunohistochemical analysis and review of the literature. 785 3

A 48-year-old man with colorectal cancer and right inguinal lymph node metastasis had previously undergone radiotherapy and chemotherapy (uracil/tegafur/leucovorin) after a colostomy in another hospital before being referred to us. Esophagogastroduodenoscopy (EGD) revealed the presence of a gastric metastatic lesion. After three courses of treatment with a modified regimen of leucovorin plus 5-fluorouracil plus oxaliplatin-6 (mFOLFOX6), EGD revealed that the gastric lesion had disappeared; computed tomography revealed that the size of the primary tumor and inguinal lymph node metastasis were markedly reduced. Subsequently, he underwent rectal resection of the primary tumor and continued treatment with mFOLFOX6 in combination with bevacizumab. We reviewed 29 similar cases from the literature, and determined that surgical resection of the tumor and appropriate chemotherapy can lead to long-term survival for patients with gastric metastases from colorectal cancer. Furthermore, positive CK20 and CDX2 expression and negative CK7 expression were useful adjuncts in the immunohistochemical diagnosis of gastric metastases from colorectal adenocarcinoma.
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PMID:[Disappearance of a gastric lesion following modified FOLFOX6 chemotherapy in a patient with metastatic colorectal cancer: a case report and literature review]. 2528 27

We report the case of a 73-year-old woman having diffuse large B-cell primary gastric lymphoma with a cirrhotic liver caused by hepatitis C virus infection. She visited our hospital with symptoms of nausea and vomiting, which appeared to be caused by stenosis due to the tumor. Metastatic tumors were seen in the gastric and jugular lymph nodes. The clinical stage was IVB with a high risk of poor prognosis according to the international index. Because of poor hepatic reserve function, standard chemotherapy could not be administered. To maintain her quality of life, palliative involved-field radiotherapy was performed. The symptoms and tumor markers significantly improved, and computed tomography and endoscopy indicated the disappearance of the primary gastric tumor. Two months after radiotherapy and her return home, she died of pneumonia. Autopsy showed neither lymphoma cells nor stenosis of gastric lesion. The significant anti-tumor effect on primary tumor in our case suggests that the involved-field radiotherapy, although palliative, can be a therapeutic option for primary gastric lymphoma patients with various complications.
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PMID:Efficient palliative involved-field radiotherapy on highly progressive diffuse large B-cell primary gastric lymphoma with liver cirrhosis. 2618 62

We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection specimen contained residual WD-NET; there was also a gastric adenoma adjacent to the NET and nodal metastasis with both adeno- and neuroendocrine components. The tumor was classified as MANEC. Of note, the entire gastric tissue was submitted and multiple deeper levels of the adenomatous lesion were examined; no adenocarcinoma was present in the primary lesion. While association of gastric adenoma with neuroendocrine neoplasm is rare, presence of biphenotypic metastasis originating from such a lesion is highly unusual and to the best of our knowledge has not been reported.
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PMID:A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma. 2796 8