Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Epithelial-myoepithelial carcinoma (EMC) is a rare neoplasm arising predominantly in the salivary glands, in particular in the parotid gland. We report the morphological features of an epithelial-myoepithelial carcinoma of the parotid gland with one lymph-node metastasis including a molecular genetic study of this tumor. Immunohistochemical and ultrastructural results confirmed the epithelial-myoepithelial dualism of the carcinoma. The loss of heterozygosity (LOH) analysis revealed different LOH results for the solid and the tubular growth pattern of the primary tumor, but showed identical findings for the solid primary tumor component and the lymph node metastasis which had also a solid appearance. LOH could be demonstrated in the whole primary tumor at D13S217 (13q12) and D18S58 (18q21). In three other microsatellite loci [D9S162 (9p22-p21), D10S251 and D10S541 (surrounding the PTEN/MMAC1 gene on 10q23-q24)], clearly recognizable LOH was found in the solid part and in the metastasis, whereas the tubular component demonstrated only a slight decrease of the same allele. No mutation or methylation of the p16 gene or alteration of the PTEN/MMAC1 gene could be found. Nevertheless, our results provoke a discussion, whether these genetic alterations could be considered as determinants of histologically and prognostically divergent types in EMC.
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PMID:Epithelial-myoepithelial carcinoma of the parotid gland-evidence of contrasting DNA patterns in two different histological parts. 1271 74

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.
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PMID:A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases. 2365 77

We performed surgical resection for a case of hepatic metastasis of an adenoid cystic carcinoma of the parotid gland. A 53-year-old woman underwent parotidectomy for primary adenoid cystic carcinoma in 2004. In 2005, she underwent resection of a local recurrence. However, in 2012, 8 years after primary tumor resection, abdominal ultrasonography revealed a hepatic tumor in the lateral segment, for which we performed laparoscopic partial hepatectomy. The hepatic tumor was histologically diagnosed as a hepatic metastasis of the adenoid cystic carcinoma of the parotid gland. At 8 postoperative months, no further recurrence was observed.
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PMID:[A case of hepatic resection of liver metastasis 8 years after resection of an adenoid cystic carcinoma of the parotid gland]. 2439 46