Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myoepithelial carcinoma is a rare locally aggressive malignant neoplasm of the salivary glands. The tumor is composed almost exclusively of tumor cells with myoepithelial differentiation and characterized by infiltrative growth and potential for distant metastasis. Tumor cells often display morphologic heterogeneity with a wide range of cytomorphologic features, such as epithelioid, plasmacytoid, spindle, and clear cell types, making its recognition challenging. Only limited reports on its metastatic behavior are available in the literature. We describe a case of metastatic myoepithelial carcinoma of the kidney from the parotid gland diagnosed by computed tomography guided fine-needle aspiration biopsy. Immunochemical studies are important to confirm myoepithelial differentiation of the tumor cells. Knowledge of the clinical history, radiographic characterization, and morphological correlation with the primary tumor are emphasized.
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PMID:Myoepithelial carcinoma of the parotid gland metastatic to the kidney: case report and review of the literature. 1985 70

Myoepithelial carcinoma is a well-known tumor of salivary gland, representing 1% of all salivary gland tumors. They have also been reported in other sites as skin/soft tissue, breast and lung. This paper reports a rare case of primary myoepithelial carcinoma in the liver, as well as discusses the findings of immunohistochemistry. The clinical manifestations, imaging characteristics, and histopathological changes of myoepithelial carcinoma in this case were described. The patient was a 33 years old female presented with a cystic tumor in the right lobe of the liver. As the liver tumor increased in size within six months, malignant neoplasm was suspected and thus anterior hepatic segmentectomy was performed. The mass composed of glandular-like structures and trabecular sheets of spindled shaped cells and epithelioid cells which were positive for myoepithelial markers. The tumor recurred within one year, in the left lobe of the liver and partial left lobe lobectomy was performed. The tumor resected showed similar histology to the primary tumor. Three months later, another recurrence was noted for which radiofrequency ablation was performed. This report presents a recurrent case of myoepithelial carcinoma in the liver and suggests the possibility of biliary origin of such tumor.
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PMID:Unusual biliary myoepithelial carcinoma in liver-case report and immunohistochemical study. 2496 80