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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the period from 1977 to 1984 173 patients with a bladder carcinoma were exposed a combined operative-radiological therapy. It includes the transurethral tumor resection and the percutaneous high voltage irradiation after an interval of six weeks. After individual irradiation planning--since 1981 by means of CT--pendulum technique has been applied exclusively for careful treatment of risk organs. The total target dose (= 80% isodose) was 56 Gy with daily application of 1.8 Gy. We attained a 5-years-healing of 27%, obviously the first two years therapy beginning were deciding for fate (2-years-survival 45%). Among infiltration grade and histological type also the primary tumor localization had prognostic relevance. In locally advanced bladder carcinoma with invasion into the environment the radiotherapy gives chance for permanent healing. Acute passing side-reactions during intensive therapy, mainly as cystitis, we recorded in 2/3 of the patients. Only with the combined occurrence of cystitis and proctitis we had to record chronic effects in 2.5% of the cases for a period of more than 5 years.
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PMID:[Results of intensive radiotherapy of bladder cancer following transurethral tumor resection]. 272 80

Thirty-five patients with prostatic adenocarcinoma were treated by bilateral pelvic lymphadenectomy and temporary implantation of iridium 192 strands with adjuvant external beam radiotherapy. With the implant the prostate received between 3,200 and 3,500 gray (Gy) followed in two weeks by small-field external beam irradiation for an additional dose of approximately 3,400 Gy. Morbidity included an ileofemoral thrombosis in one patient, and transient radiation proctitis in four patients; one patient required transurethral prostatic resection for obstruction at one year. Local response of the primary tumor was dramatic in every case at three-month follow-up. In 11 of 15 patients (73%), biopsy at one year showed no evidence of disease.
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PMID:Bilateral pelvic lymphadenectomy, iridium 192 template, and external beam therapy for localized prostatic carcinoma: complications and results. 333 96

The results of combined radiation therapy of 134 patients with cervical cancer, stage IB, using intracavitary gamma-beam therapy on the Agat-B unit were analyzed. The frequency of late radiation complications after treatment in the period of 1-5 yrs. was analyzed. The most common complications were necroepithelitis (9.7 +/- 2.6%), cystitis was less common (7.5 +/- 1.8%) as well as proctitis (1.5 +/- 1.0%). Therapeutic efficacy was assessed by primary tumor resorption, the presence of recurrences and metastases, and patients' survival. The cure rate of a primary focus was attained in 100%. Four patients died of the main disease. By the time of recurrence either osseous, organ or lymphogenic metastases were noted in them. Locoregional recurrences were undetectable in either of the patients. Radiation-induced tumors were not detected in them, either. The 5-year survival rate was 96.8%. A conclusion was made that the above method was very effective for therapy of patients with cervical cancer, stage IB and as such, should be a method of choice for them.
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PMID:[Effectiveness of combined radiotherapy of patients with stage IB cervical cancer using gamma therapy with an AGAT-B catheter device]. 341 35

Twenty-eight patients with squamous cell carcinoma of the anal canal were treated by preoperative radiation therapy and chemotherapy. The radiation therapy was given for 3000 rad (30 Gy) at 200 rad per day, 5 days a week, to the primary tumor with margin and to the pelvic and inguinal lymph nodes. Chemotherapy was given in the form of 5-fluorouracil infusion 1000 mg/m2 on days 1-4 of the radiation therapy and repeated on days 29-32 of the treatment regimen. Mitomycin C was given in the form of intravenous bolus for 15 mg/m2 on day 1. Surgery was done 4-6 weeks following the last day of radiation treatment. Twelve patients underwent anteroposterior resection, and seven of the 12 had no residual tumor in the surgical specimen, while one patient had microscopic tumor only. An additional 14 patients had complete clinical disappearance of their tumor, and, on excision of the scar, it was found free of microscopic cancer. Two other patients are clinically free of tumor but had no biopsy after therapy. While transient proctitis leukopenia and thrombocytopenia were moderate to severe, no serious complications were observed in these patients. Twenty-two patients are free of tumor and alive one to eight years after treatment. One patient died a cardiac death without tumor four years after surgery. Four patients, all with residual tumor in the specimen, have died of cancer. Their primary lesions were more than 7 cm in maximum diameter at initial examination. One patient died of disseminated disease with no local recurrence after abdominal perineal resection.
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PMID:Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. 683 48

Prostatic volume was determined by transrectal ultrasonography before and after castration in 13 patients, and after radiotherapy in 24. Measurements were done after 1, 2 and 3 months, and subsequently at 3-month intervals. Significant volume reductions occurred in the castration and radiation groups within 3 months. The decrease in prostatic volume was significantly more pronounced in the castration group during the entire study (p less than or equal to 0.01). Patients with enlargement of the prostate predominantly owing to benign prostatic hypertrophy also had a decrease in volume. No increase in prostatic volume after initial reduction was encountered for up to 9 months. In several cases progression of metastases occurred with no increase in the volume of the primary tumor. Followup may be too short to encounter local recurrence after radiotherapy or hormone-independent growth after castration. Proctitis after radiotherapy created artifacts that probably led to inaccurate measurements with ultrasonography. The technique provides a new, accurate parameter for followup of conservatively treated prostatic cancer patients. The clinical importance of the technique still remains to be determined.
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PMID:Transrectal ultrasonography in the followup of prostatic carcinoma patients. 714 95

A 64-year-old man, was admitted to the Department of Gastroenterology at another hospital in October, 2005 because of constipation and urinary retention. Endoscopic and computed tomographic (CT) examinations of biopsy specimens obtained from the rectal mucous membrane which appeared to be thickened revealed evidence of proctitis but no evidence of malignancy. The patient was referred to our hospital because of a high prostate specific anyigen (PSA) level (74.17 ng/ml), and hydronephrosis accompanied with hydroureter at the right side. Biopsy specimens taken from a prostatic tumor through a transrectal route showed histological features consistent with anaplastic adenocarcinoma which was positively stained with PSA antibody. We treated the patient with maximium androgen blackade (MAB), resulting in a decrease in plasma PSA level and amelioration of constipation as well. A 77-year-old man, visited a hospital because of constipation and high plasma carcinoembryonic antigen and carbohydrate antigen (CA) 19-9 values in May, 2005, and was diagnosed as having hyperplastic mucous membrane and atypical glands of the rectum by means of a rectal biopsy. Having been referred to our hospital, the patient received a prostate biopsy, specimens of which revealed moderately differentiated adenocarcinoma with negative PSA staining. A pelvic evisceration was performed. The eviscerated samples showed no abnormality in the rectal mucous membrane but cancer with light PSA staining in the prostatic ducts. The hormone therapy was initiated in the patient under the diagnosis of anaplastic cancer in the prostate. Since the therapy for the invasion of prostatic cancer on the rectum differs markedly from that for a primary tumor in the rectum, it is very important to differentiate accurately the one from the other.
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PMID:[Two cases of prostatic carcinoma causing a disorder of gastrointestinal transit due to rectal stenosis]. 1976 41