Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary pulmonary tumors are infrequent in childhood, therefore an accurate diagnosis and treatment is often delayed. We review the English language literature and report the clinical and pathological features of eight tumors arising in the lungs of pre-adolescent children, accessioned between 1960 and 1991 in the pathology department of a children's hospital in South Africa. The ratio of pulmonary primary tumors to secondary neoplasms and to non-neoplastic lesions of the lung examined during this period was 1:5:60. Over the last 31 years we received three plasma cell granulomas, two pleuro-pulmonary blastomas, a mucoepidermoid carcinoma, an endobronchial fibrosarcoma, and a hemangioma. All patients presented with cough unresponsive to medical treatment. The incidence and spread of primary lung tumors in children was similar to that reported from other centers. Plasma cell granuloma is the most common primary tumor in the lungs of children. Aggressive behavior is most frequently encountered with pleuro-pulmonary blastoma and rhabdomyosarcoma, and because of their association with cystic lesions careful examination of lungs is required in such cases. Most other malignant neoplasms, such as muco-epidermoid carcinoma and primary fibrosarcoma, are usually of a low grade of malignancy. A decreasing incidence of bronchogenic carcinoma seems to be reported during the first two decades of life.
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PMID:Primary pulmonary tumors in childhood: a review of 31 years' experience and the literature. 133 97

From February 1972 to December 1988, 80 cases of spinal tumor were treated in this hospital. 37 of these cases were primary tumor and 43 cases were secondary tumor. Most of the primary tumors were angioma and massive osteolysis, most of the metastatic tumors were from gastrointestinal and pulmonary carcinoma. The time of onset in both groups within half a year were 54.2% and 65.1% respectively. The dominant symptoms were pain, mass and paralysis. Except 4 cases which involved more than one vertebrae, all others involved only one vertebra. Primary tumours were mostly found in the sacrum (41.1%) and metastatic tumors were mostly found in the thoracic spine (65.2%). Sixty-three patients were treated by different combinations of operative methods. Eleven primary malignant tumor and 16 metastatic case had been followed-up for 3 months to 3 years, 25 cases died. The rate of misdiagnosis was 21.25%, which mainly occurred in the secondary group. The causes of misdiagnosis were analysed.
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PMID:[Tumors of the spine: a clinical study of 80 cases]. 226 40

Hemangiomas are the most common benign tumors occurring in the liver. However, the natural history of hepatic hemangiomas has not been well defined. Four patients (3 women, 1 man) with recurrent giant liver hemangiomas underwent either surgical or radiation therapy as initial treatment for the primary tumor. The average time until recurrence was 14 years, and each tumor weighed more than 600 g. Each of the female patients had been given chronic estrogen (Premarin) replacement therapy. Three of the four patients underwent surgical resection for intractable symptoms or progressive enlargement. It is believed that estrogen replacement therapy may play a role in the pathogenesis of these tumors. Furthermore, operative intervention should be considered in patients with recurrent giant liver hemangioma.
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PMID:Recurrent hepatic hemangiomas. Possible association with estrogen therapy. 282 59

Clinical and demographic data as well as the course of illness were analyzed in a retrospective study of 50 patients with a primary tumor or a malformation of the calvarial bones. The most frequent histological diagnosis was "eosinophilic granuloma of bone" (found in 42% of cases), followed by hemangioma, osteoma, dermoid, epidermoid and malignant tumors, and fibrous dysplasia. Local recurrence was observed in 1 patient with ossifying fibroma and 1 with a dermoid tumor, while further dissemination of illness was observed in 3 patients with "eosinophilic granuloma". In these cases, systemic drug therapy is needed. The necessity of an intensive search for further signs of illness and long follow-up periods in patients with primary localized histiocytosis X is stressed.
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PMID:[Tumors and space-occupying abnormalities of the skull calotte]. 325 4

The Bone Tumor Registry of Westphalia contains data on 7,400 tumors and tumor-like lesions of bone, 135 primary spinal tumors, 187 metastases, 98 plasmacytomas, 4 extranodal manifestations of Hodgkin and non-Hodgkin lymphomas of the vertebral column. The most frequent type of primary tumor is the chordoma (35 cases), followed by osteoblastoma (16 cases), eosinophil granuloma (16), and hemangioma (12 cases). Most of the metastases derive from carcinoma of the breast, bronchial carcinoma, or prostate carcinoma. The present review concentrates on differential diagnosis by means of histological examination, with particular reference to immunohistological methods. In addition, the necessity for complementary assessment of the X-ray findings and histology is emphasized. In particular, the current status of knowledge on the prognosis of primary spinal tumors is presented. In our experience, the preparation of nondecalcified plastic sections has proved especially valuable for diagnostic procedures using punch biopsy specimens.
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PMID:[Pathology of spinal tumors]. 332 Aug 58

13 patients with extra-medullary plasma cell tumor treated by radiotherapy in a Cancer Hospital from March 1958 to December 1983 are reported. The tumor occurred more frequently in the head and neck, particularly in the upper respiratory tract and oral cavity. Grossly, the majority of the tumor showed dark reddish polypoid masses with the surface bled easily. A misdiagnosis of polyp or hemangioma was usually made. The tumor is sensitive to radiotherapy. In the patients with recurrence or metastasis, retreatment is still effective, at least, palliative. The 5 year survival rate was 70%. A dose of 4,000-6,000 rad in 4-6 weeks is advised for the primary tumor.
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PMID:[Radiotherapy of extra-medullary plasma cell tumor--report of 13 patients]. 375 51

A mixed tumor of the omentum majus found at autopsy of a 28-year-old man with a huge liver tumor is described. The primary tumor was identified in the omentum majus by macroscopic, histologic and electron-=microscopic observations. The tumor was finally diagnosed as a mixed tumor which resembled a hepatoblastoma consisting of immature and embryonal types of epithelial component and of mesodermal tumor including hemangioma, osteoid and myxomatous tissues in the primary lesion. Widespread multiple metastases of the epithelial component mainly to the liver, and partially in the lungs, diaphragm and lymph nodes were noted. The levels of alpha-fetoprotein and carcinoembryonic antigen were within normal limits, but the epithelial component showed a resemblance to primitive hepatocytes. This tumor was discussed related to hepatoblastoma in an adult, with the features compatible with description of the same tumors reported previously in the literature.
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PMID:A mixed tumor of the omentum majus in an adult with discussion related to hepatoblastoma. 626 97

A hemangioma of the urinary bladder occurring in a 66-year-old man is described. Although hemangioma is a common lesion in many parts of the body, it remains a very rare primary tumor in the bladder. Clinically the patient usually presents with recurrent hematuria, control of which may necessitate a segmental cystectomy.
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PMID:Hemangioma of the urinary bladder. 663 96

Acquired unilateral pes planus due to hemangioma of the gastrocnemius is an unusual and rarely reported event. In recent years, three children with latent onset unilateral toe-walking due to hemangioma of the proximal gastrocnemius have received treatment at our facility. This report details the usual clinical syndrome and presents postsurgical results. Our experience suggests that in children, a presumptive diagnosis of benign hemangioma of gastrocnemius can be predicated on the basis of history, clinical examination, imaging studies, and laboratory assessment. In contrast to previous reports recommending primary tumor resection, isolated open tendoachilles lengthening can provide acceptable results with minimum morbidity.
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PMID:Latent onset unilateral toe-walking secondary to hemangioma of the gastrocnemius. 781 93

There are six major steps in the management of patients with neuroendocrine tumors (NETs) (carcinoids and pancreatic endocrine tumors). One of the steps that is increasing in its importance is the need to assess primary tumor location and tumor extent in these patients. Without such information, it is not possible to adequately manage these patients. Conventional imaging studies (CT scan, MRI, ultrasound, angiography), functional localization studies measuring hormonal gradients, endoscopic ultrasound, and most recently, somatostatin receptor scintigraphy (SRS) with [125I-DTPA-DPhe1]-octreotide have all been advocated to localize NETs in different studies. Whereas it is now established that for all NETs, except insulinomas, SRS has the greatest sensitivity, it remains unclear whether this increased sensitivity translates into increased clinical usefulness. It, therefore, remains unclear based on fiscal and clinical considerations what should be the recommended algorithm for the use of the different localization methods. To address this issue, we have recently performed two prospective studies on patients with gastrinomas. In this paper, the methods and results of each are summarized and based on these results, an algorithm for localization studies in NETs is proposed. One study assessed the role of SRS in management in 122 patients and shows that the use of SRS changed management in 47 percent of patients according to six different criteria when the patients were stratified according to their principal management problem. Determining whether liver metastases were present is one of the major goals of tumor localization studies and is frequently a source of confusion because of the difficulty in distinguishing small NETs liver metastases from hemangiomas. In the second study, the ability of SRS and other tumor localization methods to distinguish these two possibilities was assessed in 15 patients with small hemangiomas and 15 patients with small hepatic metastases (mean size 1.3 cm). SRS correctly identified 93 percent of the patients with liver metastases and was not positive in any patient with a hemangioma, suggesting it was not a liver metastases. SRS had greater negative and positive predictive value than conventional studies. Based on these two studies, and SRS's greater sensitivity and fiscal considerations, it is proposed that SRS should be the initial tumor imaging study in all NETs except insulinomas, and algorithms for the use of other localization studies in both NETs and insulinomas are proposed.
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PMID:Definition of the role of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumor localization. 982 76


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