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Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between July, 1981 and June, 1984, 40 malignant urogenital neoplasms were heterotransplanted into nude mice to clarify the biological characteristics of malignancies and screen the effective anticancer drugs against them. The primary tumor take was confirmed in 7 tumors (17.5%), including 4 of 14 renal cell carcinomas (28.6%) and 3 of 13 bladder cancers (23.1%). No primary take was recognized in renal pelvic, ureteral, prostatic and testicular cancers. Three of the 7 tumors (43%) with primary take (7.5% in total) have been serially transplanted for more than a year. These three established tumors were all renal cell carcinomas and were designated as AM-RC-1, AM-RC-6 or AM-RC-11. The take rate of tumor tissues obtained from primary and metastatic lesions was 18.2% (6/33) and 14.3% (1/7), respectively. The duration from tumor inoculation to take was examined in seven transplantable tumors. The shortest was 12 days in renal cell carcinoma, the longest was 36 days in bladder cancer and the average was 24.4 days. The correlation between the time from tumor extraction to inoculation and transplantability was investigated. The take rate was 29.4% within 3 hours, and 18.2% beyond 3 hours. The obvious effect of anti-asialo GM1 antibody on tumor take, which inhibits the natural killer activity of mice or rats selectively, was not demonstrated owing to the small number of cases. The histopathological features of seven original tumors with primary take were examined. All of the 4 renal cell carcinomas were shown to be histologically high grade and advanced. Two of the 3 bladder cancers were poorly differentiated. Therefore, the differentiation or growth rate of the tumor was suggested to be closely correlated with transplantability. The three strains of renal cell carcinomas transplanted serially for a long-term period, AM-RC-1, AM-RC-6 and AM-RC-11 disclosed a constant growth after the 7th, 9th and 10th inoculation respectively. The renal cell carcinomas serially transplantable to nude mice maintained the basic histologic findings of the original tumor even after long-term serial transplantation.
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PMID:[Study on heterotransplantation of human malignant urogenital tumors in nude mice: results of transplantation and the characteristics of the transplanted tumors]. 356 78

Although radical nephrectomy must still be considered optimal curative therapy for patients with localized renal cell carcinoma and a normal opposite kidney, partial nephrectomy is the treatment of choice when localized renal cell carcinoma is present bilaterally or in a solitary functioning kidney. In such patients, partial nephrectomy allows complete surgical excision of the primary tumor while preserving sufficient renal parenchyma to avoid the need for renal replacement therapy. Parenchyma-sparing techniques are detailed in this article.
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PMID:Partial nephrectomy for renal cell carcinoma. 357 57

Leiomyosarcoma of the left kidney seen in a 58-year-old man is reported. On April 10, 1982, he complained of left flank pain. He visited our hospital and left solitary renal cyst was suspected. He had been treated as an outpatient, but left flank pain became exacervated. On May 18, he was admitted to our hospital. On June 7, radical nephrectomy was done under the diagnosis of left renal cell carcinoma. At operation, the tumor invased directory to the psoas muscle and abdominal wall, and could not be completely resected. Pathological diagnosis was renal cell carcinoma with sarcomatoid change. On July 1, he was discharged from the hospital. In December, left flank distention appeared and back pain became exacervated. On February 8, 1983, he was readmitted to our hospital. Low density area was found in left psoas muscle by CT scanning and recurrence of renal cell carcinoma was suspected. alpha-Interferon therapy had been done, but tumor increased remarkably and caused ileus. He died on June 14, 1983. The autopsy revealed a child head-sized cystic tumor in the upper retroperitoneal space, a 5 X 5 X 5 cm metastasis of the left lobe of the liver, a 3 X 3 X 4 cm tumor to the left upper lobe with cavity formation and direct invasion into the spleen, diaphragma and gastric serosa. These metastatic lesions were leiomyosarcoma. Retrospectively, the primary tumor of kidney revealed primary leiomyosarcoma of kidney.
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PMID:[A case of leiomyosarcoma of the kidney]. 372 30

We reviewed 181 cases of metastatic renal carcinoma treated from 1973 to 1982 to characterize the factors associated with prolonged survival. Cumulative survival from the date of first known metastasis was analyzed with respect to the patient age, sex, interval free of disease, performance status, site of metastasis and nephrectomy. Survival for the entire group was 73 per cent at 6 months, 48 per cent at 1 year and 9 per cent at 5 years. Age and sex did not influence survival. Improved survival was correlated with long interval free of disease between nephrectomy and discovery of metastases, normal performance status, metastases limited to the lung parenchyma and removal of the primary tumor. The effect of nephrectomy on survival was not separable from effects of patient selection. The subgroup of patients with the favorable characteristics had longer survival than was reported previously for advanced renal carcinoma (50 per cent at 3 years, median 24 months). These patients may be appropriate candidates for more aggressive therapy. These factors should be considered in the analysis of results of future clinical trials on metastatic renal carcinoma.
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PMID:Prognostic factors in metastatic renal carcinoma. 373 98

Nuclear deoxyribonucleic acid ploidy was determined in 206 samples of well differentiated clear cell renal carcinoma via a previously described technique on paraffin-embedded archival material. Grade 2 tumors had a higher incidence of abnormal deoxyribonucleic acid patterns than grade 1 tumors. Of stage 1 well differentiated clear cell renal tumors 60 per cent had a normal deoxyribonucleic acid histogram pattern, whereas 67 per cent of higher stage tumors had an abnormal pattern. The existence of abnormal nuclear deoxyribonucleic acid histogram patterns in the primary tumor tissue had a significant correlation with subsequent development of metastatic disease, independent of tumor grade and stage. The 10-year actuarial survival rate was 62 per cent for patients with normal deoxyribonucleic acid histograms and 37 per cent for patients with abnormal patterns. These results demonstrate that nuclear deoxyribonucleic acid ploidy measured by flow cytometry is an important variable in the classification and determination of prognosis for patients with clear cell renal carcinoma.
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PMID:Well differentiated clear cell renal carcinoma: significance of nuclear deoxyribonucleic acid patterns studied by flow cytometry. 379 58

Thirty-three cases of true distant metastasis to the uterine cervix from primary tumors in extragenital or intragenital sites have been studied. The group comprised 12 ovarian tumors, 10 colonic tumors, 5 gastric tumors, 4 mammary tumors, 1 renal cell carcinoma, and 1 transitional cell carcinoma of the renal pelvis. Data of mode of presentation, interval between diagnosis of primary tumor and diagnosis of cervical metastasis, and subsequent survival are presented. The literature is reviewed with consideration of the problems of clinical and pathologic diagnosis.
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PMID:Epithelial tumors metastatic to the uterine cervix. A study of 33 cases and review of the literature. 395 7

The deoxyribonucleic acid profiles of 54 renal cell carcinoma specimens (43 primary and 11 metastatic tumors) from 50 patients are reported. Deoxyribonucleic acid ploidy and the proportion of cells in the S phase (S index) were determined by flow cytometry. Of the patients 44 had advanced disease (stages III and IV). The frequency of deoxyribonucleic acid aneuploidy (presence of a distinct aneuploid stemline) was 74.1 per cent for all tumors and 77.3 per cent for stages III and IV tumors. The percentage of aneuploid tumors did not vary significantly among the various histological types, between stages III and IV tumors, or between primary and metastatic tumors. S indexes for aneuploid tumors were significantly higher than for diploid tumors. When deoxyribonucleic acid ploidy of the tumor alone was considered with respect to survival, there appeared to be a slight survival advantage for patients with diploid tumors compared to those with aneuploid tumors. However, a larger patient population (especially patients with early stage disease) and a longer followup will be required to determine the prognostic role of flow cytometry deoxyribonucleic acid analysis of renal cell carcinoma. Flow cytometry analysis of 4 primary renal tumors and their subsequent metastases revealed concordance in ploidy in 3 specimens. In 1 patient the primary tumor showed a diploid pattern whereas the subsequent metastasis showed 2 aneuploid stemlines. Possible explanations for this observation are listed. Further flow cytometry studies of deoxyribonucleic acid profiles in renal cell carcinoma are warranted and should improve our understanding of the biological and clinical behavior of this tumor.
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PMID:Flow cytometric deoxyribonucleic acid analysis of primary and metastatic human renal cell carcinoma. 398 3

A patient with renal cell carcinoma, first presenting because of symptoms from an osseous metastasis, was examined with CT and magnetic resonance imaging (MRI). Both the primary tumor and the metastasis were well demonstrated by both methods. MRI tissue characterization showed that the T1 values in the kidney and the metastasis were the same, as were the T2 values. This may mean a potential for the MRI to define primary tumors when a metastasis is found.
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PMID:Magnetic resonance imaging and tissue characterization of a renal cell carcinoma and its osseous metastasis. Report of a case. 399 24

We report a case of renal cell carcinoma metastatic to the pituitary gland. A review of the literature indicated breast carcinoma to be the most frequent primary tumor metastatic to this site, while renal cell carcinoma metastasis has not been reported previously. This case emphasizes the capricious nature of renal cell carcinoma, particularly in a patient presenting with no evidence of disseminated disease.
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PMID:Metastatic renal cell carcinoma presenting as an intrasellar mass on computerized tomography. 400 5

The object of this study was to characterize the antigens evoking an immune response in renal cell carcinoma (RCC) patients receiving specific active immunotherapy with irradiated autologous tumor cells and Corynebacterium parvum as adjuvant. Seventy serum samples from 11 patients with RCC undergoing specific active immunotherapy were evaluated. Fifty of the 70 serum specimens (71%) had immunoglobulin G antibody directed to autologous tumor cells. Absorption studies were completed on 4 patients (S.E., M.M., R.N., S.V.) with 2 patients (S.V. and M.M.) demonstrating reactivity to a RCC-associated antigen present on their autologous tumor cells. One patient's serum (R.N.) was absorbed not only with autologous tumor cells but also with an allogeneic RCC cell line. The fourth patient's (S. E.) serum reactivity was able to be absorbed only with autologous tumor cells and several, but not all, of the clones of that autologous cell line. Patient S.E. serum binding by clones of RCC cell line RPMI-SE was seen to vary from no ability to bind RPMI-SE in some clones to double the parental binding in others. Consistent with this finding was the demonstration that high serum-binding clones could absorb Patient S.E. serum reactivity to autologous RCC cells, while low binding clones could not. These data suggest a measure of heterogeneity among the parental RCC cell line, as demonstrated by its clones. This study has shown that the autologous tumor vaccine with adjuvant used here was an immunogenic therapeutic agent. The response mounted by these patients was a response to a RCC-associated antigen with the level of reactivity changing with the number of immunizations and disease status. Also suggested by this work is the possible primary tumor heterogeneity, as demonstrated by the differential reactivity seen among clones of a RCC cell line established from such a primary tumor.
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PMID:Humoral immune response of patients receiving specific active immunotherapy for renal cell carcinoma. 402 29


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