Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0677930 (primary tumor)
 20,210 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Levels of alkaline phosphatase were measured in the primary tumor of 26 patients with osteosarcoma. One of seven patients with a tissue alkaline phosphatase level less than 0.6 microM/min/mg developed pulmonary metastases. In contrast, 16 or 17 patients with a tissue alkaline phosphatase level greater than 0.6 microM/min/mg developed pulmonary metastases. It thus appears that tissue alkaline phosphatase levels of primary osteosarcomas are strongly correlated with prognosis (p less than .01).
Cancer 1979 Dec
PMID:Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. 29 11

On the basis of our experience in 57 liver resections (hydatid cyst in the liver 22 times, 7 hepatic cysts, 5 liver abscesses, 7 benign and 16 malignant hepatic tumors) a few tentative conclusions are drawn: A reliable diagnosis and assessment of operability is only possible on laparotomy. Echinococcus alveolaris should be operated as radically as possible. Primary hepatic tumors should be removed as well as malignant hepatomas and their metastases. Simultaneous extirpation of the primary tumor and metastases has given encouraging results so far, especially in easily resectable carcinomata of the colon and rectum. Cytostatic followup therapy is absolutely essential in all cases of malignancy.
 ...
PMID:[Clinical and operative aspects of liver resection (author's transl)]. 30 82

Intrinsic body defences against cancer depend on cells of the lymphatic and reticulo-endothelial systems, the T-lymphocytes playing a central role in the immunological rejection of tumor. The mononuclear cell infiltrate in tumor tissue is largely composed of immunocytes of the T-lymphocyte series. A heavy concentration of lymphocytes in stroma of bladder tissue affected with cancer appears to indicate a good prognosis. After removal of the primary tumor, recurrences are noted only after a relatively long interval, infiltration of the tumor into bladder muscle being hindered by immunocyte activity. It is clear, from comparison with dinitrochlorbenzol skin testing, that the extent of lymphocyte infiltration in tumor tissue is a measure of the cellular immune status of a patient with cancer.
 ...
PMID:[Influence of T-lymphocytes in bladder cancer on appearance and infiltration of recurrences (author's transl)]. 30 5

Spleen cells of C57BL/6J mice bearing a poorly immunogenic syngeneic tumor T241 have been shown to suppress the mitogen-induced proliferative responses of normal spleen cells. However, no suppressive effect of these cells was observed on the generation of cytotoxic cells following immunization in vitro against H-2 histocompatibility antigens. The suppressor activity disappeared rapidly after the removal of the primary tumor. Spleen cells of tumor-bearing mice also suppressed the mitogen-induced stimulation of normal spleen cells of mice of different H-2 loci. Removal of phagocytic cells with carbonyl iron treatment had very little effect on the suppressor activity. Suppressor activity was enhanced following fractionation of cells through nylon wool columns. The suppressor population was found to resist anti-immunoglobulin serum and complement treatment, but treatment with anti-thymocyte serum and complement drastically reduced the suppressor activity. These results indicate that cells with suppressor activity have characteristics of T-lymphocytes.
Cancer Res 1979 Aug
PMID:Presence of suppressor cells in spleens of mice bearing a weakly immunogenic syngeneic tumor. 31 43

The lack of an improvement in the gross survival statistics for colorectal cancer during the last decade and the negative results of randomized trials, suggests that 5-FU used as an adjuvant treatment has not increased survival. Current chemotherapeutic drug combinations, however, may prove effective in the adjuvant situation. The adjuvant use of preoperative radiation has shown improved survival in one randomized study and no change in the second study. Current preoperative radiotherapy studies using a more effective radiation dose will confirm the effect of preoperative radiation both on the primary tumor control and on metastases. Current postoperative adjuvant trials incorporating radiation, chemotherapy or a combination of the two, when completed, will provide clear indications for the physician as to the optimum treatment of Duke's B and C cancer of the colorectum. Three national randomized studies for inoperable, recurrent or residual carcinoma of the colorectum are testing the effect of radiation alone or in combination with chemotherapy or chemotherapy followed by immunotherapy.
Cancer 1977 Jul
PMID:Gastrointestinal cancer--colon (surgery-radiotherapy). The role of radiation therapy in the management of rectosigmoid cancer. 32 39

Results for non-simultaneously diagnosed malignant tumors from Connecticut indicate that individuals with one malignant neoplasm have 1.29 times the risk of developing a new independent primary tumor when compared to individuals who never had cancer (P less than 0.01). However, the increased risk of multiple primary tumors is highly selective on a site-specific basis. Table 135 presents Connecticut Registry data indicating the risk of a subsequent primary malignancy by anatomic site of the later primary in patients with a first primary cancer. Tables 136 and 137 present tabulations for anatomic sites with statistically significant excesses and deficiencies, with an analysis by time interval between the two malignancies. Finally, Table 138 presents figures showing histologic confirmation for site-group paris with significant excesses of observed-over-expected later primary malignant neoplasms. The reader should bear in mind that just as the risk of subsequent primaries varies with the anatomic site of the subsequent primary (Table 135), the risk is also highly dependent upon the anatomic site of the first primary cancer (Chapters 6-12).
Recent Results Cancer Res 1977
PMID:Multiple primary malignant neoplasms. The Connecticut experience, 1935-1964. 33 19

A metastasis from a bronchial carcinoid tumor presented as an isolated breast mass in a 58-year-old female. A review of the English literature revealed four cases of metastatic carcinoid to the breast that presented as an isolated breast mass. In each case, radical mastectomy was performed after the lesion had been interpreted clinically and pathologically as a primary carcinoma. When the primary tumor was excised, all cases had either regional lymph node or liver involvement. A mass was the usual presenting sign of the metastatic deposit. No metastasis was reported to be greater than 2 cm in diameter. No axillary lymph nodes were reported to contain tumor. Frozen section preparations may not be adequate to differentiate a primary carcinoma of the breast from a metastatic carcinoid tumor, thereby necessitating permanent sections, special stains, review of previously resected neoplasms, or electron microscopy. The first mammogram of a metastatic carcinoid to the breast is reported with this case.
Cancer 1977 Dec
PMID:Breast metastasis: an unusual manifestation of a malignant carcinoid tumor. 33 42

In 18 patients, histologic evaluation of a solitary distant metastasis with characteristic hypernephroid pattern subsequently led to the diagnosis of renal cell carcinoma. The metastatic lesion was treated surgically in 15 cases; 14 patients underwent radical surgery and one patient with a solitary kidney underwent partial nephrectomy. Osseous metastases were predominant (12 out of 18). There was an excellent morphologic agreement between metastatic and primary lesions: in no case were metastases less differentiated than the primary tumor. Therefore in all cases of metastases with hypernephroid structures an aggressive search for renal malignancy is required. Five-year survival was 5% and identical to a group of 61 patients with metastases and a symptomatic renal cell carcinoma at diagnosis. The poor prognosis was not influenced by surgical extirpation of the solitary metastasis.
 ...
PMID:[Extrarenal manifestations of renal cell carcinoma: the primary metastatic lesion (author's transl)]. 34 84

A randomized study compared the effects of combination chemotherapy (high-dose methotrexate, adriamycin, and vincristine) with immunotherapy in the form of transfer factor in the adjuvant treatment of patients with nonmetastatic osteogenic sarcoma after apparent complete surgical ablation of the primary tumor. Thirty-two patients were evaluated. Of 22 patients who received chemotherapy, three died of drug-related complications and six were alive without disease recurrence between 260 and 673 days after operation. Ten patients in the transfer factor group converted their markers, and of these, five were alive without recurrence 420--753 days after operation. Neither treatment program was considered superior with respect to disease-free survival.
Cancer Treat Rep 1978 Feb
PMID:Adjuvant therapy for nonmetastatic osteogenic sarcoma: an evaluation of transfer factor versus combination chemotherapy. 34 19

Cancer of the lip occurs in about 90 percent at the lower lip arising in the vermilion mucosa. In tumor stage I the type of repair depends on the size of the primary tumor. Small tumors are best treated by a simple full-thickness W-excision with direct closure, occasionally combined with vermilionectomy. The simple W-excision is the most common procedure in lip cancer (65%). After excision of greater tumors, repair may be performed by cross lip flap of the Estlander-Abbe type or by the fan-flap of the Gillies type. Large defects are closed with Dieffenbach's or Burow's flap. The Burow's technique give better cosmetic and functional results than the Dieffenbach's method. Also in comparison to the cross lip flaps Burow's technique advantages. The orificium of the mouth remains wide, the lateral angle is not distorted and the tumor may be removed with a broad margin in the normal tissue. Therefore, the Burow's technique is frequently applied (30%) displacing the other methods(is less than 5%). At least the practice of two techniques may be sufficient in dermato-surgery, the W-excision with or without vermilionectomy; and the Burow's technique with its modifications.
 ...
PMID:[Lip carcinoma and its surgical treatment]. 35 Aug 6


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>