Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0677481 (urinary frequency)
 1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 2002, the International Continence Society (ICS) derived a consensus symptomatic definition of overactive bladder (OAB) as urinary urgency, with or without urge incontinence usually with urinary frequency and nocturia, in the absence of pathologic or metabolic factors that would explain these symptoms. OAB is a highly prevalent disorder that increases with age in both sexes and that has a profound impact on quality of life. Although the prevalence of OAB in men and women is similar in Japan, help-seeking in women has been reported to be lower than that in men. One reason is most women with OAB consider it not a serious disease, and another reason is they hesitate to consult a doctor, especially a urologist, because they feel ashamed. On the other hand, the pathophysiology of OAB remains poorly understand. We have demonstrated that Kit-positive interstitial cells in the suburothelial layer and smooth muscle layer played an important role in the mechanism for maintaining bladder function and pathophysiology of OAB. In addition, we showed the effects of Glivec, a c-Kit tyrosine kinase inhibitor, reduced spontaneous action potential in detrusor smooth muscle. Glivec may prove useful for the treatment of OAB in the future.
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PMID:[Overactive bladder in female and new strategy]. 1762 47

We report a case of marginally resectable gastrointestinal stromal tumor (GIST) in the pelvis treated with neoadjuvant intent before subsequent successful surgical resection. A 46-year old man presented with urinary frequency and rectal discomfort with tenesmus. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a 12 cm diameter mass between the bladder and rectum and the margin of the tumor and prostate was unclear. No metastases were evident. Trans-rectal needle core biopsy confirmed c-kit positive GIST. Because of the locally advanced nature of the tumor,immediate surgical resection would have required total pelvic exenteration with eternal colostomy and urinary diversion. Therefore,the patient was treated with imatinib mesylate 400 mg daily in anticipation of adequate tumor size reduction to enable a more simplified surgical approach. After 3 months of imatinib therapy,MRI demonstrated a reduction in tumor size of 60%. Consequently,a complete surgical resection including the bladder,prostate and part of the sigmoid colon with temporary ileostomy and ileal conduit was performed. Pathological findings of the resected specimen showed widespread degeneration with cystic changes,necrosis, and hypocellularlity,as well as nodules of residual viable c-kit positive tumor cells. The patient has been treated with imatinib mesylate for 39 months following the operation without tumor recurrence.
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PMID:[Successful resection of a gastrointestinal stromal tumor in the pelvis with imatinib mesylate as neoadjuvant therapy]. 2158 85