Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677481 (urinary frequency)
1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The anamnestic, clinical and urodynamic findings of 377 consecutively investigated women were evaluated. 86 (23%) patients showed bladder instability. The intensity of involuntary bladder contractions and the occurrence of incontinence in association with involuntary detrusor contractions influenced the clinical significance of unstable bladders. The maximum urethral closure pressure however had no influence on it. Urge incontinence was the most reliable symptom distinguishing those patients with bladder instability. Frequency of micturition, nocturia and nocturnal enuresis were less reliable in this respect. Urinary tract infections showed no correlation to bladder instability.
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PMID:[The clinical significance of the unstable bladder (author's transl)]. 691 66

Videocystourethrography was used to investigate 214 incontinent women. Their urinary symptoms were assessed in relation to urodynamic findings. Nocturia, nocturnal enuresis and urge incontinence were the most reliable symptoms distinguishing those patients with detrusor instability. Frequency of micturition and urgency were less reliable in this respect, and it was felt that these symptoms were not indications for videocystourethrography.
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PMID:A comparative study of symptoms and objective urodynamic findings in 214 incontinent women. 719 20

It is known that a great number of subjects, mainly little girls, frequently go to pediatric's observation for recurrent episodes of pollakiuria, dysuria or burning miction. They often complain enuresis, sometimes tenesmus so intense that they arrive at the incontinence (urge incontinence). Many of these cases, quickly defined as cystitis, really revealed that they weren't. Repetitively negative bacteriologic examinations allow us to classify them as "sham syndromes", as Stephens called them. According to what we said above, we wondered whether any recurrent cystitis are not favoured by missed observation of definite rules.
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PMID:[Recurrent cystitis in children: do predisposing factors exist for its onset?]. 826 56

Micturitional histories and urodynamic studies were performed in 14 patients with syringomyelia. Eleven patients were revealed to have urinary symptoms including difficulty of voiding in 8, urinary retention in 3, nocturnal and diurnal urinary frequency in 3, urinary incontinence in 2, and sense of urgency and enuresis in one. These urinary symptoms appeared after 5.3 years (ranging from 2 months to 13 years) from the occurrence of the neurological symptoms. Urodynamic studies revealed detrusor hyperreflexia in 7, detrusor areflexia in 4, detrusor-sphincter dyssynergia in 4 and uninhibited sphincter relaxation in 2 patients. Analysis of the motor unit potentials of the external sphincter revealed 5 of 6 patients had high amplitude or polyphasic neurogenic changes. Supranuclear as well as nuclear types of parasympathetic and somatic nerve dysfunctions seemed to be responsible for micturitional disturbance in our patients with syringomyelia. During the follow-up period of 2 to 63 months, urinary symptoms gradually improved in 4 of 6 patients after syringosubarachnoid shunts and in 3 of 4 after alpha-adrenoreceptor blocking agents.
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PMID:Micturitional disturbance in syringomyelia. 898 5

Newer research results have shown that the previous classification of enuresis into nocturnal, nocturnal and diurnal and diurnal forms is not sufficient. Day wetting constitutes a heterogeneous group of syndromes, which should be considered as functional urinary incontinences and which require differentiated diagnostics and therapies. General aspects of functional urinary incontinence are discussed, including: classification, epidemiology, symptomatology, especially the association with urinary tract infections, vesicoureteral reflux, obstipation and encopresis. The rate of psychiatric problems seems to be increased compared to children with nocturnal enuresis. Methodological problems of previous studies are discussed. General guidelines regarding diagnostics and therapy include the requirement of sonography, uroflowmetry with pelvic-floor-EMG, urinalysis and specific therapy-forms. The three most important syndromes are urge incontinence with urge symptoms, frequent micturition, holding manoeuvres due to a physiological instability of the detrusor and lower, mostly secondary psychiatric symptoms. Voiding postponement is a general refusal syndrome with a psychiatric etiology, characterized by a postponement of micturition and retention of urine. The detrusor-sphincter-dyscoordination has as the main symptom a paradox contraction instead of relaxation of the bladder sphincter during micturition. It is recommended hat the previous classification should be left in favour of more specific diagnoses to ensure specific, causally effective therapies.
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PMID:["Enuresis diurna" is not a diagnosis--new results on classification, pathogenesis and therapy of functional urinary incontinence in childhood]. 915 96

Micturition disorders were studied retrospectively in a series of 165 children over a period of 15 years. Among patients without lesions of the upper tract at the time of diagnosis (group A, n = 131), 18 (14%) had persistent nocturnal and diurnal enuresis: one urethral stenosis and six vesicoureteric reflux required surgery; three experienced persistent pollakiuria and enuresis. Among patients with upper urinary tract damage at the time of diagnosis (group B, n = 34), seven presented with recurrent urinary tract infection, five with nocturnal and diurnal enuresis and three with urolithiasis. In the long term, only 52% of them had normal renal function and two were successfully transplanted. Micturition disorders following treatment of posterior urethral valves are frequent and usually related to the so-called valve bladder syndrome. Iatrogenic complications and mortality rate have dramatically decreased during the recent years but long-term renal function impairment remains the most critical problem.
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PMID:[Persistent urination disorders after treatment of posterior urethral valve: incidence and semiology]. 918 Oct 7

Nocturnal enuresis (NE) can result from an interaction of unstable detrusor contractions, delayed arousal from sleep, and nocturnal polyuria. Some children with NE can hold urine well for several hours during the day and have isolated nocturnal enuresis, while others manifest diurnal voiding symptoms (DVS) as well, including urinary frequency, urgency, urge incontinence, and pelvic withholding. The pathogenesis of NE in patients with isolated NE may be different than in those with NE and DVS. In children with NE and DVS, detrusor instability may play a major role in the causation of their voiding problems, whereas delayed arousal from sleep in response to a full bladder may be a major contributor to NE in patients with isolated NE. The treatment should address the underlying pathogenic factors. The commonly used treatment regimens are described. Motivation and efforts of the child in training the bladder are vital to achieving cure of enuresis.
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PMID:Nocturnal enuresis in children. 960 95

Imperative micturition occurs rather frequently. The data of different authors favour driptan (oxibutinin) in this condition. In the urological clinic of the Medical Institute oxibutinin hydrochloride was tried since 1991. A total of 354 patients were treated (328 females, 12 males and 14 adolescents). The indications to the treatment were the following: instability of the detrusor, urethra or both, isolated forms of pollakiuria, some forms of enuresis, irritation in benign prostatic hyperplasia, correction of detrusor instability in enuresis before operation. Oxibutinine hydrochloride produced positive results in various forms of imperative micturition with symptoms of urgent incontinence (urgent enuresis) or without them. The drug produced a response in many socially maladapted individuals considered incurable.
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PMID:[Use of driptan (oxybutinin) in patients with urgent forms of urination disorders]. 1005 23

This retrospective study discusses the incidence of symptomatic voiding dysfunction, the etiological factors and the changes with age and with increasing duration of follow up in 67 boys treated for posterior urethral valves and followed up for a period ranging from 1-21 years. Twenty three of the 67 patients (34.3%) had symptomatic voiding dysfunction; the commonest symptom being nocturnal enuresis with diurnal urgency and frequency. Data in this study suggests a definite decrease in the incidence of urinary incontinence as the patient grows older or as the duration of follow up after valve fulguration increases. A Tc-99m DRCG based uroflowmetry was available in 31 of the 67 patients at the time of this review and evidence of detrusor dysfunction was identified in 9 of the 31 patients on the basis of uroflowmetry. Of significance was the detection of detrusor dysfunction on uroflowmetry in 3 patients with a history of normal urinary control and urinary stream with persistent post treatment hydroureteronephrosis eventually culminating into renal failure. Imipramine therapy was given to 10 of the 17 patients with symptoms of urinary frequency, urgency and nocturnal enuresis with a significantly symptomatic improvement in 9 of these patients. Urinary incontinence, detrusor dysfunction and its effect on the upper tracts and renal function is a significant determinant of the long term outcome of the boys treated for posterior urethral valves and this paper emphasises on the need to carefully evaluate and treat this aspect of all valve patients.
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PMID:Urinary continence following posterior urethral valves treatment. 1079 36

A 4-year-old Jewish boy presented with dysuria, urinary dribbling, increased urinary frequency, and new onset of diurnal enuresis. An infiltrating solid mass involving the entire bladder wall was found. Biopsy revealed "tumor-forming" eosinophilic cystitis, a rare bladder lesion of unclear cause. Antitoxocariasis treatment was unsuccessful. High-dose corticosteroids failed. The child's clinical condition and bladder sonographic findings continued to deteriorate. Treatment with cyclosporin A was given for 8 months, with a complete clinical, radiologic, and histopathologic cure and no side effects. Two years of follow-up showed a complete recovery.
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PMID:Eosinophilic cystitis in a 4-year-old boy: successful long-term treatment with cyclosporin A. 1173 40


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