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Query: UMLS:C0677481 (urinary frequency)
 1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinical guideline and algorism for interstitial cystitis and hypersensitive bladder syndrome has been developed by a group of East Asian urologists as a revised form of the Japanese guideline for interstitial cystitis. The guideline defines interstitial cystitis (IC) as a disease of the urinary bladder diagnosed by 3 requirements; 1) a characteristic complex of lower urinary tract symptoms, 2) bladder pathology such as Hunner's ulcer and bladder bleeding after overdistension, and 3) exclusions of confusable diseases. The characteristic symptom complex is termed as hypersensitive bladder syndrome (HBS), which is defined as bladder hypersensitivity, usually associated with urinary frequency, with or without bladder pain. For the definite diagnosis of IC, cytoscopy or hydrodistension is crutial; HBS is the diagnosis when IC is suspected but not confirmed by the 3 requirements. Numerous therapeutic options are available; however, most of them lack in high level of evidence, leaving a few as recommended therapies. Etiology of IC are multifactorial; the interaction among nervous, immune and endocrine factors forms a vicious cycle, provocating and maintaining inflammatory reactions in the bladder. The inclusion and efficacy criteria for clinical trials should be standardized to enhance the clinical research for this disabling disease, which has proved to be more prevalent than previously believed.
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PMID:Clinical guidelines for interstitial cystitis and hypersensitive bladder syndrome. 1954 99

Painful bladder syndrome/interstitial cystitis is a disabling disease of the urinary bladder that mainly affects women. It is of unknown etiology and can appear in all age groups. The main symptoms - bladder pain and urinary frequency - may completely govern the life of the unlucky person suffering from the disease. Treatment includes diet, behavioral modifications, medical treatments, inclusive specific-pain treatment and surgery, but it is unfortunately often insufficient. The disease is rare and lacks a specific definition as well as proper diagnostic criteria. Surgical treatments include neuromodulation, transurethral surgery, bladder augmentation and urinary diversion with or without cystectomy. This article examines the documentation, or lack of, for the often drastic surgical procedures performed to improve quality of life in patients with this disorder.
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PMID:Surgical treatment of painful bladder syndrome/interstitial cystitis. 1980 95