Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677481 (urinary frequency)
 1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients with neurofibromatosis (von Recklinghausen's disease) manifesting mictional disturbance are presented. They were a man aged 41 years (A) and 3 women aged 26 (B), 46 (C) and 32 (D) years, and their chief complaints included urinary retention, dysuria, urinary frequency and urinary retention. None of them had any organic obstructive disorders in the lower urinary tract. Case A who had neurofibroma at the C2 and L1-2 vertebral bodies had inactive bladder and his urinary flow rate was less than 10 ml/sec. In case B, cystometrogram was initially normal, but changed to inactive bladder type one year later and neurofibromas were found in the vertebral bodies of Th7-8 and L2. Case C, who had inactive bladder cystometrically, underwent removal of 1-acoustic neurinoma and neurinomas of cauda equina. Case D had hyperactive bladder and received resection of the neurofibroma of vertebral bodies from C6 to Th4. The finding of cystometrogram and type of urinary miction disorders suggested vertebral neurofibroma at an early stage.
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PMID:[Manifestation of mictional disturbance in four cases of von Recklinghausen's disease]. 310 55

A 56-year-old man presented with long-standing, mild urinary frequency 6 years after radical prostatectomy. Pathologic assessment showed presence of organ confined prostate cancer (pT2a), Gleason 6 (3+3). Since the time of surgery, PSA level was undetectable and the patient remained without evidence of recurrent disease. However, digital rectal examination revealed the presence of a very large mass palpable on the anterior rectal wall. Therefore, the patient underwent abdominal/pelvic MRI which demonstrated presence of a solid, well-circumscribed pelvic mass extending from the level of the sacrum posteriorly to the anterior abdominal wall. Histologic examination of percutaneous biopsy of the mass was suggestive of schwannoma. The patient underwent laparotomic excision of the mass, which was confirmed to be a schwannoma, with its characteristic slender spill cells and elongate nuclei. No intra-operative complication was reported. The patient has no evidence of recurrence with complete resolution of urinary symptom one year after surgery.
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PMID:Large presacral schwannoma after radical prostatectomy. 1652 59

Presacral tumours represent a heterogeneous group of predominantly benign and occasionally malignant neoplasms. These tumours, though rare, frequently present either incidentally or with vague symptoms. Schwannomas of the presacral region are one variant described as benign tumours of neurogenic origin. The case of a large presacral schwannoma in a 26-year-old man, who was treated for irritable bowel syndrome for 4 years, is presented. The patient presented with intermittent constipation, a feeling of incomplete evacuation of the bowel and vague abdominal discomfort relieved by defecation. The symptomatology worsened and constipation became frequent, and the patient experienced increased urinary frequency. Baseline investigations were normal and ultrasonography of the abdomen revealed a pelvic mass, which on CT scanning was revealed to be a large retrorectal mass. The tumour was resected and histology revealed it to be a schwannoma. This unique case is presented to emphasise that irritable bowel syndrome must be a diagnosis of exclusion, especially if atypical symptoms are present.
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PMID:Presacral schwannoma treated as irritable bowel syndrome. 2279 78

Presacral or sacral schwannomas are relatively rare clinical entities thought to account for only 1 in every 40,000 hospitalizations. These lesions are benign, frequently monofocal, and arise from the exiting sacral nerve roots. Lesions are often asymptomatic, but may present with bulk symptoms (constipation, urinary frequency), sciatica, lower extremity weakness, and para-axial lumbosacral pain. At present, the treatment of choice for these lesions is gross total resection, with an approach dictated by the size of the intrasacral component. Despite numerous isolated case reports, few case series exist. Of those extant series, none are multi-institutional and only a handful describe multiple alternative approaches for the treatment of these tumors. Here we describe a series of seven patients treated at two tertiary care centers for sacral schwannoma with post-operative follow-up as far as 6 years.
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PMID:Management of presacral schwannomas-a 10-year multi-institutional series. 3129 93

The urinary bladder schwannoma is an extremely rare primary urologic tumor. Schwannoma arises from the Schwann's cells in the nerve sheaths and is almost associated with von Recklinghausen's disease. We report a case of schwannoma in a 35-year old female who presented with urinary frequency for 2 months with absence of evidence of von Recklinghausen disease and successfully treated with transurethral resection of bladder lesion (TUR_B). To the best of our knowledge, this represents only the 10th case of benign schwannoma of the urinary bladder in a patient without von Recklinghausen disease. We report a case of an isolated schwannoma of the urinary bladder, and also searched the English literature as we had access to bladder schwannoma.
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PMID:Isolated schwannoma of the urinary bladder: a case report and review of the literature. 3263 6