Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677481 (urinary frequency)
 1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-two girls with recurrent urinary tract infection and endoscopically proved cystitis cystica were studied prospectively to determine control of infection with long-term, continuous nitrofurantoin or sulfisoxazole (6 to 12 months), effect on the bladder changes and rate of recurrence of infection after discontinuation of medication. Infection was controlled equally with both drugs but, despite adequate control, 24% had evidence of cystic changes upon completion of the treatment period. An additional 44% became reinfected during the 1-year followup with no drugs. Only one-third of those presenting with urinary frequency, urgency and urge incontinence had improvement of these symptoms with control of infection alone. It appears that childhood cystitis cystica is the response of the bladder to long-term, inadequately treated bacterial lower urinary tract infection. Many months to years of continuous medication are required for healing. Toilet retraining, in addition to anticholinergics, also may be necessary to achieve urinary control.
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PMID:The clinical significant of cystitis cystica in girls: results of a prospective study. 66 Jul 39

Frequency of micturition and dysuria were prominent symptoms in 135 (57%) of 237 women with urethral syndrome. Ureaplasma urealyticum, Mycoplasma hominis and Chlamydia trachomatis were the principal organisms associated with the urethral syndrome (38.41%, 28.14% and 11.11%, respectively). Escherichia coli was cultured from four patients and Herepes genitalis and Neisseria gonorrhoea were isolated from five patients. Infections with more than one organism were frequent. Thirty-one of 135 patients were infected by two organisms, 27 by three and 4 patients by four microorganisms. Vaginitis due to Garnerella vaginalis, Candida spp. and Trichomonas vaginalis was discovered in 52 (39%) of 135 patients.
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PMID:Sexually transmitted diseases in women with urethral syndrome. 290 82

Interstitial cystitis (IC) is manifest by years of urinary frequency, urgency, and bladder pain and on cystoscopy, is diagnosed by petechial hemorrhages or ulcers. The etiology is unknown; the prominent theories are that IC is an autoimmune disease or is linked to increased permeability of the bladder mucosa. Although sought, no infectious agent has ever been identified. The disease has many characteristics of a chronic infection and the author's opinion is that an infectious disease has not been properly ruled out. To do so would require culture of bladder epithelium (not just urine) using special culture and non-culture techniques such as polymerase chain reaction. Infection can easily be integrated into the autoimmune and permeability theories of IC pathogenesis. A possible analogue for this disease is chronic gastritis in which Helicobacter pylori has been identified as an etiological agent.
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PMID:Is interstitial cystitis an infectious disease? 781 76

An 8-year-old, female spayed miniature schnauzer was presented for pollakiuria and gross hematuria. Infection-induced struvite urolithiasis with concurrent bacterial urinary tract infection was diagnosed. The treatment is described, followed by a brief discussion of struvite stones and their medical management.
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PMID:Dissolution of infection-induced struvite bladder stones by using a noncalculolytic diet and antibiotic therapy. 1553 83

To report our experience with implant infection after two-stage sacral nerve stimulator placement. We reviewed the records of all patients who underwent implantation with a sacral nerve stimulator for the management of refractory cases of urge urinary incontinence, urinary frequency, and non-obstructive urinary retention. Baseline demographic data, interval to the development of infection, and the organism cultured are reported. After stage II neurostimulator placement, 5 out of 37 (13.5%) women required device removal for culture positive wound infections. Patients returned an average of 147.4 days after device implantation with evidence of infection. Infection occurred a minimum of 33 days, a median of 76 days, and a maximum of 461 days after sacral nerve stimulator implantation. The most common pathogen cultured was Staphylococcus aureus. After device removal, all patients resolved their infections. Two patients underwent uncomplicated reimplantation in the contralateral buttock 14 and 16 days after stimulator removal. The risk of infection after tined lead pretest and neurostimulator placement may be higher than previously observed in older techniques.
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PMID:Implant infection after two-stage sacral nerve stimulator placement. 1798 10