Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0677481 (urinary frequency)
 1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical effects of oxybutynin hydrochloride on lower urinary tract function at a dosage of 2 mg given orally three times daily (6 mg/day), were studied on 10 patients with neurogenic bladder by cystometry and measurement of residual urine. There was a significant increase, of about 34% in FDV, but no significant changes in MBV, or maximum voiding pressure of residual urine after administration. Urinary frequency, incontinence and urgency in subjective symptoms were decreased in patients given this drug. The effective rate (excellent and good) was 50% in global evaluation. Side effects were observed in 4 out of 10 patients; 3 had dry mouth and 1 had diarrhea. There were no serious side effects. These findings suggested that oxybutynin hydrochloride may be a useful drug for neurogenic bladder.
 ...
PMID:[Clinical effects of oxybutynin hydrochloride on neurogenic bladder]. 353 26

Oxybutynin chloride has been clinically used for the relief of symptoms associated with voiding in patients with uninhibited neurogenic and reflex neurogenic bladder in the USA. The present clinical and urodynamic studies were the first meticulously in patients with uninhibited neurogenic and reflex neurogenic bladder in Japan. A single oral dose of oxybutynin chloride (3 or 6 mg) did not induce any change either in subjective symptoms or in urodynamic studies; however, in the continual administration study, 7 of 9 patients showed an improvement in the symptoms associated with voiding. The drug reduced urinary frequency, urgency and incontinence, and significantly increased the volumes at the first desire to void (FDV) and maximum desire to void (MDV) in cystometry. Furthermore, no serious adverse reactions were observed, and hence the drug seems to be of clinical significance.
 ...
PMID:Clinical reevaluation of the effect of oxybutynin chloride on uninhibited neurogenic and reflex neurogenic bladder. 396 17

We describe 2 patients with progressive systemic sclerosis (PSS) who manifested characteristic pathologic abnormalities in the urinary bladder. Increased connective tissue deposition in the lamina propria and between smooth muscle bundles was demonstrated in both patients and endovascular proliferation in small arteries of the bladder was noted in one patient. Both patients had persistent unexplained microscopic hematuria; one patient manifested urinary frequency and incontinence. The relationship of these clinical abnormalities to the pathologic findings in the bladder is unclear. Structural or functional abnormalities of the urinary bladder may develop in patients with PSS.
 ...
PMID:Pathologic involvement of the urinary bladder in progressive systemic sclerosis. 405 1

Acquisition of control of micturition in children involves several stages, the most critical being the bladder immaturity phase. Although the passage from bladder automatism of the neonate to coordinated conscious bladder-sphincter activity in adults is usually a problem-free period, it is nevertheless a critical and sometimes dangerous phase in certain subjects. Purely functional disorders may induce, above a certain physiological limit, a true pathologic state considered up to the present as being organic in nature and requiring urodynamic exploration to confirm their individuality. This bladder immaturity syndrome has the common denominator of diurnal or nocturnal urine leaking, sometimes with an associated lower urinary tract infection in young girls. The first part of this review discusses a clinical trial conducted in 1 097 children (840 girls, 257 boys) age 4 to 15 years, with the "urine-leaking" symptom, divided into 2 groups as a function of its diurnal or nocturnal prevalence: Group I: diurnal incontinence alone: 285 children Group II: diurnal and nocturnal incontinence: 812 children Investigations included: a clinical examination including a full past history to determine possible infectious origin, the primary or secondary nature of the disorder, possible family history and particularly any associated diurnal micturitional disorders such as pollakiuria and urgency; cytobacteriology of urine; an I.V.U. reduced to a minimum of images; cystography and micturitional study; cystometry. Results in each group were expressed analytically, and showed assimilation of the 2 groups, having in common the incontinence-urine leaking symptom, whether it occurred during the day or night, with the diurnal manifestations of pollakiuria and urgency. This clinical feature derived from simple questioning was accompanied in 9 out of 10 cases by cystographic anomalies (notched bladder outline, modified proximal urethra in young girls, sometimes vesico-renal reflux) and cystometric changes (vesical hyperactivity and hypersensitivity). These findings provide better understanding of the significance of these clinical manifestations and their place within the framework of the urinary bladder immaturity syndrome. After a summary of the physiology of the bladder-sphincter apparatus and the stages of acquisition of micturitional control, with definition successively of the automatic, immature and adult bladder, the second part of the report discusses the urinary bladder immaturity syndrome itself. Symptoms are dependent on the urodynamic factors involved.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:[The bladder immaturity syndrome. Apropos of 1097 cases]. 407 51

A 20-yr-old male presenting a 2-yr history of excessive urinary urgency and frequency was treated with a three-phase behavioral intervention. Progressive urinary retention training was first suggested to decrease urinary frequency and increase functional bladder capacity (phase one). The patient was not able to comply with the instructions, showing a phobic fear of accidents and an over-valued consideration of the social consequences of incontinence. Systematic desensitization, in vivo desensitization and cognitive restructuring were implemented in phase two. The patient was then able to comply with the progressive urinary retention training (phase three) and completely overcame his problem. Gains were maintained at 6 and 12-month follow-ups. The results suggest that progressive urinary retention training alone is effective both at the behavioral and physiological levels, but its application is facilitated by a consideration and modification of the patient's subjective attitude towards excessive micturition frequency and its feared consequences.
 ...
PMID:Treatment of excessive urinary frequency and urgency by desensitization and progressive retention training. 613 96

The present study utilized EMG biofeedback in the treatment of functional bladder-sphincter dyssynergia, a learned incoordination of bladder and urethral sphincter activity during voiding. The condition is usually associated with a history of painful urination due to bladder infections, surgery, or harsh toilet training. The subject was an 8-year-old girl with chronic diurnal urinary frequency, urge incontinence, and nocturnal enuresis. Treatment consisted of intensive instruction in alternately tensing and relaxing her lower pelvic musculature, as well as relaxing during voiding. These exercises were accompanied by EMG biofeedback from perianal and perivaginal surface electrode sites. Home practice consisted of the tense-relax exercise, relaxation during voiding, and self-monitoring and record-keeping. There were 17 sessions over a period of 9 months. No medication was used. Marked reduction (to normal levels) in diurnal urgency and frequency occurred by the 3rd week of therapy, and complete recovery of normal function, including nocturnal continence without waking, occurred by the 13th therapy session, 5 months after therapy began. Follow-up 1 year after therapy revealed that these gains were being maintained. Pre- and posttherapy urodynamic studies corroborated the achievement of normal urinary function.
 ...
PMID:EMG biofeedback for functional bladder-sphincter dyssynergia: a case study. 635 88

Ten patients (4 boys and 1 girl, 4 adult women and 1 man) were operated upon for incontinence due to epispadias (5 children and 2 women), or the result of multiple operations for stress incontinence (2 women), or of a transurethral bladder neck resection (the adult man), using Leadbetter's technique, which is described. In 4 patients with a sufficiently long trigonum, it was not considered necessary to perform ureterovesical reimplantation. Interesting results were obtained as they were assessed as very good in 4 and good in 2 of the 7 cases of epispadias, good in 1 of the 2 cases of sphincter lesions following surgery, and poor after endoscopic resection of the bladder neck in the man. All patients retained a normal upper urinary tract. In those patients who became continent, the new urethra measured 3.3 to 5 cm in length, whereas it was too short and dilated in cases remaining incontinent. Initial pollakiuria improved in the children after several months. These findings suggest that the ureter should be reimplanted in all cases, to allow the formation of a muscular, newly formed urethra of sufficient length. This operation appears to be effective for treating incontinence due to epispadias and traumatic sphincter lesions in women. It gives poor results in incontinence after prostate surgery and from neurological bladder. Reeducation of the child is as important as selection of patients for operation and a strict operative technique.
 ...
PMID:[Surgical treatment of total urinary incontinence based on Leadbetter's technic]. 649 47

Stress urinary incontinence (SUI) in women is more frequent in the multiparous patient, especially in those postmenopausal after withdrawal of hormonal stimulation of the pelvic supportive tissues. With loss of support of the vesical neck and urethra, sphincter incompetence may result. A patient whose symptoms are purely irritative (urinary frequency, nocturia, urgency, or urge incontinence), without a significant degree of stress incontinence, should not benefit from any operation.
 ...
PMID:Practical approach to stress urinary incontinence. 668 93

We evaluated by video urodynamic study 60 children between 4 and 16 years old who had presented with various combinations of urinary frequency, diurnal incontinence, enuresis, voiding symptoms, recurrent urinary infections and upper tract changes. A number of seemingly distinct categories of detrusor dysfunction could be identified, which may have a bearing on logical treatment selection. In addition, abnormalities of sphincter activity were noted in 12 children. The limitations and interpretation difficulties of urodynamic studies in children are stressed.
 ...
PMID:Urodynamic abnormalities in neurologically normal children with micturition dysfunction. 672 65

Urinary frequency, urgency, bladder discomfort, and incontinence are among the most common causes for women to seek urologic evaluation. The value of endoscopy and radiographic studies is limited because they define only structural problems. This study presents 325 women who, in addition, underwent multifunction urodynamic study to identify functional problems. The merits and role of this investigation in the workup of this population group is discussed, together with the therapeutic implications of the various results.
 ...
PMID:Urodynamic evaluation in women with frequency, urgency symptoms. 686 42


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>