Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0677481 (urinary frequency)
 1,126 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty seven cases of stage D prostatic carcinoma were analyzed according to age, chief complaints, histopathological types, metastatic sites, and serum acid and alkaline phosphatase levels. In spite of metastasis, which were in 62 cases (92.5%) to bone, in 17 cases (25.4%) to lymph nodes, and in 3 cases (4.5%) to the lung, the most common chief complaints were symptoms related to the primary lesion, such as dysuria and urinary frequency. There was no significant correlation between the incidence of bone metastasis and histopathological type. However, higher incidence of lymph node metastasis was observed in the histological types of moderate and poorly differentiated adenocarcinoma than well differentiated type. When cases were divided into two groups by age, significant differences were observed between younger (64 less than or equal to years old) and older (greater than or equal to 65 years old) groups in the following points: 1) Histopathologically, well differentiated type was not recognized in the younger group, while three histological types of well, moderate and poorly differentiated adenocarcinoma, were equally distributed among the older one. 2) Although there was no significant difference in the incidence or the numbers of metastatic sites to bone between the two groups, the younger patients had less symptoms related to bone metastasis. The prominent symptoms in the younger group were complaints about voiding.
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PMID:[Clinical features of stage D prostatic carcinoma]. 281 19

A 60-year-old female complained of gross hematuria and urinary frequency on November 27th, 1982. Cystoscopic examination revealed papillary invasive tumor around the bladder neck and a transurethral biopsy showed signet ring cell carcinoma. Since there was no adenocarcinoma in any other organs, we diagnosed it as primary signet ring cell carcinoma of the urinary bladder. Total cystectomy with ileal conduit and post-operative irradiation were performed, but she died on May 13th, 1983. We summarize 16 cases of primary signet ring cell carcinoma of the urinary bladder including this case and discuss this rare condition.
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PMID:[A case of signet ring cell carcinoma of the urinary bladder]. 300 67

A 63-year-old man was admitted with the complaints of macrohematuria, sense of residual urine and urinary frequency. Physical examination revealed an enlarged hard prostate and left scrotal mass. The pathological diagnosis of the needle biopsy specimen of the prostate showed undifferentiated adenocarcinoma. The patient underwent bilateral orchiectomy for hormone therapy of prostatic carcinoma and treatment of suspected left testicular tumor. The histology of testicular tumor revealed metastasis from carcinoma of the prostate. Metastasis of the testis from prostatic carcinoma is rare in spite of the high incidence of the primary tumor. Clinical findings on testicular metastasis from carcinoma of the prostate obtained in 62 cases reported in available literature are reviewed and discussed in detail.
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PMID:[Prostatic carcinoma with metastasis to the testicle: a case report]. 372 49

Clinical study of HCFU for head and neck cancer was performed HCFU at a daily dose of 600 to 900 mg. Was orally administered to 30 patients, including 5 patients with metastases. The primary sites of cancer were: larynx 9 cases, mesopharynx 6 cases, hypopharynx 5 cases, maxilla 5 cases, nasopharynx 3 cases, parotid gland and floor of the mouth one each. All of them were squamous cell carcinoma except a case presenting parotid lesion caused by adenocarcinoma. In 7 cases receiving the single therapy of HCFU for one month, a positive response was presented in one out of 7. Twenty-three cases treated HCFU in combination with radiation, 11 showed complete response (CR: over 90% decrease of tumor size), 6 showed partial response (PR: over 50% decrease), 3 showed minor response (MR: over 25% decrease), and 3 were diagnosed as no change (NC). Positive responses evaluated as PR or above obtained at the mean cumulative dose of 25.7 Gy and HCFU 15972 mg. Four cases receiving HCFU in adjuvant chemotherapy were studied only for clinical toxicity. Clinical toxicities of HCFU in 30 patients were presented in transient pollakiuria (7 cases), neurotoxic effect (2), eruption and diarrhea (one each). Symptoms similar to anemia and unconsciousness caused by the intake of alcohol were found in 6 patients. Although positive effect of HCFU was observed only in one case being administered singly, it presented better results in more cases when administered in combination with radiation. The combination therapy also made the lesions respond faster than by radiation therapy only. Intake of any alcohol is not advisable.
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PMID:[Clinical study of HCFU and radiation therapy for head and neck cancer]. 688 99

We report a case of prostatic malacoplakia clinically diagnosed as prostatic cancer. A 65-year-old man was seen with increased urinary frequency, and urinalysis disclosed moderate pyuria. After the administration of antibiotics for several days, the urine was sterile and the symptoms disappeared, but findings of digital examination of the prostate were compatible with prostatic cancer. Transperineal needle biopsy of the prostate was reported as poorly differentiated adenocarcinoma on the piece from the left lobe. Following further evaluation, the patient underwent radical prostatectomy under the preoperative diagnosis of stage B1 prostatic cancer. However, histological diagnosis of the surgical specimen was malacoplakia of the prostate.
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PMID:[Malacoplakia of the prostate: report of a case]. 853 94

Urachal carcinoma is a rare neoplasm of the urinary bladder. We present two cases. Case 1, a male patient, noted urinary frequency and micturition pain for two months. The surgical specimen from a partial cystectomy represented a transitional cell carcinoma that developed from a urachal diverticulum. Case 2, a female patient, had a long history of infraumbilical mass without umbilical discharge or urinary symptom. Pathologically, the mass showed a papillary adenocarcinoma arising from a urachal cyst. Both patients received successive en bloc operation. Local recurrence and peritoneal carcinomatosis occurred. Both expired 19 and 13 months respectively, after initial diagnosis.
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PMID:Urachal carcinoma: a report of two cases. 885 87

A 55-year-old woman was admitted with urinary frequency. She had undergone augmentation ileocystoplasty due to tuberculous bladder atrophy 37 years previously. Cystoscopy revealed a tumor on the posterior wall which had been augmented with the ileum. Partial cystectomy and bladder reconstruction using a segment of ileum and ascending colon were performed. Gross inspection showed a 15 x 10 mm, papillary tumor on the ileal mucosa near the vesico-ileal anastomosis. Histologically, moderately differentiated adenocarcinoma infiltrating into the muscle layer was surrounded by the normal ileal mucosa. She has been free of recurrence for 2 years postoperatively. This is the 8th case of adenocarcinoma following augmentation ileocystoplasty reported in the Japanese literature.
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PMID:[Adenocarcinoma occurring 37 years after augmentation ileocystoplasty for tuberculous bladder atrophy: report of a case]. 939 13

Nephrogenic adenoma is a benign epithelial tumour localised at the level of the urothelium and caused by metaplasia of the urothelium following prolonged aggressive stimulation over time, for example trauma or chronic urinary infection. Even a diverticulum, in whatever site it is localised, is subject to an increased risk of neoplastic transformation of the urothelium. It above all affects male subjects, with a male/female ratio of 3:1 over the age of 20, which is inverted in younger subjects. The most frequently affected site is the vescical trigonum in 72% of cases, followed by the pelvic tract of the ureter (19%) and urethra. The majority of patients is asymptomatic or reports aspecific symptoms: the most frequent picture is macroscopic hematuria, owing to the rich vascularisation of the tumour. This is followed by irritative type signs such as pollakiuria, strangury, posturination dripping and sometimes painful tenesmus. Differential diagnosis is necessary for pale cell adenocarcinoma, parauretral cysts and Gartner duct's cysts which may be associated with urethral diverticulum, localised on the bottom, and rarely symptomatic. Diagnosis is based on retrograde urethrography, cystography and endoscopic tests, with biopsy if necessary. NMR provides further details regarding the site, localisation and benign or malignant nature of the lesion. Treatment is surgical: endoscopic (transurethral) if the dimension are limited, or traditional using a suprapubic or transvaginal route if it is associated with diverticulum. Prognosis is discrete and depends on the timeliness with which the factors predisposing metaplasia are eliminated.
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PMID:[Nephrogenic adenoma arising from an urethral diverticulum in a female. Report of a case and review of the literature]. 1022 60

A 72-year-old man presented with pollakiuria and dysuria. His prostate was the size of an apple and hard on digital rectal examination and the serum prostate specific antigen (PSA) level was 73 ng/ml (RIA). Ultrasonography revealed bilateral hydronephrosis and the serum creatinine level was 13.2 mg/dl. CT scanning of the abdomen demonstrated swelling of paraaortic lymph nodes. Transrectal needle biopsy of the prostate gave a diagnosis of moderately differentiated adenocarcinoma. Accordingly, the final diagnosis was prostate cancer (cT3N4M1, stage D2). Immediately after bilateral percutaneous nephrostomy, treatment with an LH-RH agonist (goserelin) and flutamide was commenced. Serum creatinine was 6.6 mg/dl at the start of antiandrogen therapy and decreased to 1.8 mg/dl after 27 days. A 125 mg flutamide capsule was administered at 7 a.m., and blood samples were collected 4 hours later on days 1, 2, 3, 5, 6, 8, 12, 14, 17, 18 and 27. The OH-flutamide concentration was measured. There was no significant correlation between serum creatinine and the OH-flutamide concentration. After implantation of goserelin (3.6 mg depot), blood samples were obtained at 11 a.m. on days 8, 12, 14, 15 and 25. The serum goserelin level was measured. The serum goserelin level increased to a peak on day 14, as described previously, but the peak value of 9.63 ng/ml was higher than that reported before (mean +/- SD 2.848 +/- 0.199).
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PMID:[Serum concentrations of flutamide and goserelin in a prostate cancer patient with obstructive nephropathy: a case report]. 1050 Sep 60

A 57-year-old woman visited a physician with complaints of anorexia and pollakiuria. Because a pelvic tumor and ascites were detected, she was referred to our department. Douglas pouch puncture revealed adenocarcinoma cells. Further examination showed an advanced gastric cancer with peritoneal dissemination. The cancer was judged to be unresectable. Chemotherapy with a combination of TS-1 and CDDP was performed before the operation. After 2 courses of the chemotherapy, her complaints disappeared, although abdominal CT confirmed remaining peritoneal dissemination. After 7 courses of chemotherapy, abdominal CT showed that the peritoneal dissemination had disappeared. Total gastrectomy and lymph node dissection were performed. Histological findings of the stomach revealed complete disappearance of cancer cells in the stomach and the regional lymph nodes. We confirmed that the TS-1/CDDP therapy resulted in a complete response to advanced gastric cancer and peritoneal dissemination. We recommend that chemotherapy be continued until the peritoneal dissemination disappears.
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PMID:[A case of advanced gastric cancer with peritoneal dissemination responding remarkably to TS-1/CDDP combination chemotherapy]. 1719 53


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