Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0600142 (hot flushes)
 1,242 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Estrogen receptor 1 10.7
NCF 9.0
Neurokinin B 9.0
NK3R 8.8
CEE 8.7
BIG1 8.6
PAIS 8.5
neurokinin B 8.4
NK3 receptor 8.2
WHI 7.9
TTK 7.4
CBG 7.3
FACT 7.2
MGA 7.1
kisspeptin 7.1
SULT1E1 7.0
gp17 7.0
corticosteroid binding globulin 7.0
aromatase 6.9
oestrogen receptor 6.9
HTX 6.9
EPT 6.9
L17 6.8
follicle-stimulating hormone 6.8
cytochrome P450 2D6 6.8
ATAC 6.8
ARH 6.8
BRI 6.7
NKB 6.7
sterol regulatory element-binding protein-1c 6.7
glycodelin 6.6
mammaglobin 6.6
sex hormone-binding globulin 6.4
FSH 6.4
caspase 7 6.4
PHS 6.4
Intermedin 6.3
LHRH 6.3
LHbeta 6.2
estrogen receptor 6.2
GPR54 6.1
vesicular glutamate transporter 2 6.1
C30 6.0
GnRH receptor 6.0
ESX 6.0
CCK-4 6.0
GDS 5.9
FACE 5.9
STH 5.9
CYP2D6 5.9
ESR2 5.8
eukaryotic translation initiation factor 4E 5.8
period 3 5.7
IGFBP3 5.7
hormone receptor 5.7
NALP3 5.6
Sex hormone-binding globulin 5.6
TTR 5.6
EDRF 5.6
CTB 5.6
CS2 5.5
delta 4 5.5
GTT 5.5
HSP72 5.5
Sclerostin 5.5
CAF 5.5
thyroxine-binding globulin 5.5
ASL 5.4
organic anion transporting polypeptide 5.4
TTP 5.3
sex hormone binding globulin 5.3
HTR 5.3
duo 5.2
GRP 5.2
AMH 5.2
estrogen receptor alpha 5.2
PMS 5.1
Aromatase 5.1
prostate-specific antigen 5.1
DHEAS 5.1
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Disease
Vasomotor disturbance 13.6
Postmenopausal symptoms 13.1
Vulvovaginal atrophy 11.6
vaginal atrophy 11.4
Surgical menopause 11.2
Autoimmune oophoritis 11.2
menopausal syndrome 10.8
atrophic vaginitis 10.4
Endometrial atrophy 10.2
Pelvic endometriosis 9.9
Withdrawal bleeding 9.5
urinary system cancer 9.4
demineralization of bone 9.3
Primary insomnia 9.3
endometrial hyperplasia 8.9
FBD 8.9
psychoactive substance abuse 8.8
Central precocious puberty 8.8
Gallbladder disease 8.7
retinal vein thrombosis 8.4
premature menopause 8.3
gynecomastia 8.2
Dyspareunia 8.2
Male hypogonadism 8.2
postmenopausal bone loss 8.1
Pseudopregnancy 8.0
hypomenorrhea 8.0
emotional instability 8.0
Female sexual dysfunction 7.9
recurrent breast cancer 7.8
vaginal discharge 7.7
amenorrhea 7.7
MWS 7.5
sleep disturbances 7.3
premenstrual syndrome 7.3
Estrogen deficiency 7.3
locally advanced cancer 7.2
uterine cancer 7.2
pathological personality 7.2
dyschromia 7.1
oophoritis 7.1
hypoactive sexual desire disorder 7.1
sexual dysfunction 7.1
ARH 7.0
fibrocystic breast disease 7.0
myoma 6.9
Prinzmetal 6.9
HTX 6.9
HTX 6.9
uterine leiomyoma 6.8
vaginal infection 6.8
Dubin-Johnson syndrome 6.8
schizophrenic psychosis 6.8
fear of cancer 6.8
premenstrual dysphoric disorder 6.8
secondary amenorrhea 6.7
melancholia 6.7
Muckle-Wells syndrome 6.7
vascular headache 6.7
Pelvic inflammatory disease 6.7
derealization 6.7
endometriosis 6.6
galactorrhea 6.6
reactive depression 6.6
vaginal candidiasis 6.6
Rust 6.6
osteoporosis 6.5
xerostomia 6.5
endometrial cancer 6.4
premature ovarian failure 6.3
galactorrhea 6.3
nasopharyngitis 6.3
impotence 6.3
CHH 6.2
neurotic depression 6.2
cancer relapse 6.2
hyperviscosity syndrome 6.1
PMS 6.0
paroxysmal supraventricular tachycardia 6.0
PHS 6.0
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Symptom
hot flushes 14.6
generalised tiredness 13.1
hot flashes 12.9
Vaginal dryness 12.8
Climacteric symptoms 12.5
Breast discomfort 12.3
menopausal symptoms 11.5
leg cramps 11.0
night sweats 11.0
cold sweats 10.8
feeling dizzy 10.6
Breast tenderness 10.6
Breast pain 10.5
Crawling 10.4
peri-menopausal 10.2
mastalgia 9.4
excessive sweating 9.1
lassitude 8.8
Fatigability 8.7
feeling tired 8.4
menometrorrhagia 8.4
Spotting 8.2
feeling depressed 8.1
bewilderment 7.8
photopsia 7.6
forgetfulness 7.6
flushing 7.4
insomnia 7.4
frequent urination 7.2
irregular bleeding 7.1
Extrapyramidal symptoms 7.0
limb pain 6.8
leg edema 6.8
stomach pain 6.7
abdominal cramps 6.6
arthralgia 6.5
dizziness 6.2
Poor sleep 6.1
abdominal fullness 6.0
nausea 5.9
chills 5.9
asthenia 5.9
pelvic pain 5.7
skin irritation 5.6
nipple discharge 5.5
bloating 5.5
mental fatigue 5.5
myalgia 5.4
fatigue 5.4
tingling 5.3
headache 5.3
chest tightness 5.1
bone pain 5.0
discomfort 5.0
discomfort 5.0
paresthesia 5.0
numbness 4.9
nausea and vomiting 4.9
sleepiness 4.7
dry skin 4.7
hypersomnia 4.6
muscle rigidity 4.6
tense 4.6
urinary frequency 4.5
nasal congestion 4.5
dysuria 4.4
masculinization 4.3
bitter taste 4.2
vertigo 4.2
erythema 4.1
hoarseness 4.1
photophobia 4.0
despair 4.0
anorexia 3.9
back pain 3.9
vomiting 3.9
memory loss 3.8
lethargy 3.8
sneezing 3.8
exhaustion 3.7
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Drug
Didrogesterone 14.6
Bazedoxifene acetate 11.7
Cetrotide 11.4
Trimegestone 11.1
cetrorelix acetate 10.6
Idoxifene 10.5
Tibolone 10.5
Vorozole 10.4
Femara 10.3
Zoladex 10.3
Zoladex 10.2
Aromasin 10.2
Ethamsylate 10.2
Casodex 9.9
Arimidex 9.8
Encore 9.7
Evista 9.6
Premarin 9.4
Fulvestrant 9.0
Tianma 8.9
Epidoxorubicin 8.9
Cetrorelix 8.6
Raloxifene 8.6
Lupron 8.6
Drospirenone 8.5
Triptorelin 8.4
Naprosyn 8.4
Gabapentin 8.3
Moclobemide 8.1
Tramal 8.0
Estriol 7.9
Reboxetine 7.7
RAL 7.7
Soybean oil 7.4
Mirtazapine 7.4
Estrogens 7.1
Depo-Provera 6.9
Aliskiren 6.6
Luteinizing 6.6
DMAP 6.5
Clonidine 6.4
Duloxetine 6.4
Clomiphene citrate 6.3
Domperidone 6.2
Levonorgestrel 5.5
Sulpiride 5.4
ICI 5.3
Glycyrrhiza 5.2
OTC 5.1
DMSA 5.1
EE2 5.0
Xanthium 4.9
TAK 4.7
OTC 4.6
Vitamin B12 4.4
MAP 4.3
Vitamin E 4.0
Ginseng 4.0
Norplant 3.9
Check 3.7
NAG 3.6
vitamin E 3.5
Herceptin 3.5
TAT 3.4
HCG 3.3
Fluorescein 3.2
CTX 3.2
MRC 2.9
Kenyan 2.9
Fluorescein 2.8
niacin 2.8
CTX 2.2
CAM 2.1
Nephron 2.1
ROC 1.7
Spectrum 1.7
CTX 1.3
caffeine 1.2
ascorbate 1.2
Monit 0.5
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Enzyme
EPT 6.4
prostate-specific antigen 5.2
TOR 4.1
PRA 3.9
ornithine transcarbamylase 3.9
TAT 3.4
alkaline phosphatase 2.8
alanine aminotransferase 2.5
gamma-glutamyl transpeptidase 2.5
CPT 2.5
monoamine oxidase 2.3
CYP3A4 2.0
GSK 1.9
renin 1.5
acid phosphatase 1.0
aspartate aminotransferase 0.2
acetylcholinesterase -0.1
thrombin -0.4
luciferase -0.6
focal adhesion kinase -0.8
ERK -0.9
catalase -1.1
superoxide dismutase -1.2
Compound
Nafarelin 11.8
Colprone 10.8
Exemestane 10.1
Anastrozole 10.0
Droloxifene 9.8
Opipramol 9.7
Dolasetron 9.4
Premarin 9.3
Medroxyprogesterone 9.3
4-OH-A 9.3
Letrozole 9.0
Cyproterone acetate 9.0
Bicalutamide 8.9
Raloxifene 8.7
Toremifene 8.7
Dydrogesterone 8.5
Levcromakalim 8.5
Norgestrel 8.3
Equol 8.2
Paroxetine 8.2
Cilag 8.2
2,3-dinor-thromboxane 8.1
Tamoxifen 8.0
Pregnane 8.0
Tamoxifen 8.0
Premarin 7.9
Norethisterone 7.9
Venlafaxine 7.8
Trazodone 7.7
Mirtazapine 7.6
Ritodrine 7.6
Estriol 7.4
Elan 7.1
Danazol 7.1
Clomiphene 7.1
Estrogen 7.0
MGA 7.0
Estrogen 7.0
Aminoglutethimide 6.9
Levonorgestrel 6.8
Elan 6.8
Isoflavone 6.8
Geigy 6.8
DMAP 6.6
MPA 6.6
MPA 6.6
FBF 6.5
MPA 6.5
Androstenedione 6.3
Nystatin 6.3
indane 6.3
Nystatin 6.3
Androgen 6.2
Domperidone 6.2
RU-486 6.2
EAA 6.0
Sumatriptan 6.0
PMS 5.9
Estradiol 5.9
Tranexamic acid 5.8
TTS 5.8
Citalopram 5.8
Buspirone 5.7
Sertraline 5.7
Chlorogenic acid 5.6
LPR 5.5
Bupropion 5.5
Organon 5.5
Risperidone 5.4
FTA 5.4
Luteolin 5.2
Tramadol 5.2
Estrone 5.2
Calcitonin 5.1
GPT 5.0
ICI 5.0
BMD 4.9
Progesterone 4.9
Testosterone 4.9
VM-26 4.9
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