Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0600142 (hot flushes)
 1,242 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study investigated the knowledge, views and experience of perimenopausal women in relation to hormone replacement therapy at the menopause. It was carried out in a semi-rural practice, using a postal questionnaire to which the response rate was 85%. The majority of women (90%) had heard of hormone replacement therapy, mainly from the media. However, only a quarter of the women had approached their general practitioner about the therapy, principally because they were experiencing definite symptoms. The majority of women believed hormone replacement therapy could benefit hot flushes and osteoporosis but only about 10% felt it could reduce the risk of a stroke or myocardial infarction. Over half of the women expressed one or more concerns about the therapy and the dominant anxiety was about cancer. These findings form the basis for improved care in terms of identifying needs and providing more appropriate information.
Br J Gen Pract 1991 Mar
PMID:Hormone replacement therapy--a survey of perimenopausal women in a community setting. 203 53

Fifty-five depressed menopausal patients took part in a randomized double-blind cross-over trial using ;Harmogen' (piperazine oestrone sulphate) and placebo. The Beck depression inventory, hot flush counts, and patients' subjective assessment of well-being were used to assess clinical status. Hormonal, biochemical and coagulation profiles were carried out. Hot flushes improved significantly on oestrogen compared with placebo. Depression scores and well-being showed significant and equal improvement on oestrogen and placebo. Significant improvement in flushes in patients on placebo was observed in the first half of the trial but did not occur in the second half, in patients who had previously taken oestrogen. No significant changes occurred in biochemistry. Coagulation tests showed acceleration of the prothrombin time in patients taking ;Harmogen' compared with those on placebo. Piperazine oestrone sulphate is a relatively weak but safe oestrogen preparation, effective in treatment of vasomotor symptoms but no more effective than placebo in the treatment of depression.
J R Coll Gen Pract 1981 Mar
PMID:Is oestrogen therapy effective in the treatment of menopausal depression? 626 83