Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0600142 (hot flushes)
 1,242 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

10 postmenopausal patients with hot flushes were given ethinyl estradiol, 20 mg daily, 3 weeks out of 4, for 16 weeks. Peripheral venous samples for coagulation factors 2, 7, 10, 7 + 10 complex and the coagulation inhibitor anti-thrombin 3 were taken twice before treatment; in the 6th, 10th, and 14th week of treatment, and 6-8 weeks after treatment stopped. There was a significant increase in mean values of coagulation factors 7, 10, and 7 + 10 complex in the 10 patients taking ethinyl estradiol. Factors 10 and 7 + 10 complex reached a peak after 6 weeks of treatment and then declined while the mean value of factor 7 continued to rise to a maximum of 138 + or - 11% by the 10th week of treatment. Factor 10 was the only factor significantly raised at the end of 14 weeks treatment. There was no significant change in factor 2 and anti-thrombin 3 in the patients on the ethinyl estradiol. These effects on coagulation factors during ethinyl estradiol therapy are, in general, similar to those found during treatment with conjugated equine estrogens and estradiol valerate in a previous study from the same laboratory. It appears that equipotent doses of ethinyl estradiol and "natural" estrogens have similar effects on these coagulation factors.
 ...
PMID:Changes in coagulation factors in postmenopausal women on ethinyl oestradiol. 46