Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0600142 (hot flushes)
 1,242 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen postmenopausal women with severe hot flashes had continuous recordings of finger temperature and skin resistance as objective indexes of flushing episodes, and serial measurements of anterior pituitary hormones as indirect indexes of hypothalamic neurotransmitter activity. Significant increases of growth hormone, adrenocorticotropic hormone (ACTH), and luteinizing hormone (LH) occurred with maximal concentrations at 30, five, and 15 minutes, respectively, after the onset of the skin temperature rises. No significant fluctuations of prolactin (PRL), thyroid-stimulating hormone (TSH), or follicle-stimulating hormone (FSH) were observed. The mean serum cortisol concentration increased 15 minutes after the hot flash, presumably consequent to the preceding elevation of ACTH. Pituitary ACTH release may be secondary to hypothalamic cooling, whereas increased growth hormone and LH output and the thermoregulatory adjustments comprising the flushing episodes are all consistent with cyclic episodes of increased hypothalamic norepinephrine activity.
 ...
PMID:Pituitary hormones during the menopausal hot flash. 609 54

In ageing people there is a gradual decrease of serum level of testosterone(T), dehydroepiandrosterone(DHEA) and growth hormone (GH) in both sexes and a cessation of estrogen secretion in women. There is no decrease of C-V risk after estrogen and medroxyprogesterone treatment in post menopausal women in primary or in secondary prevention. There is a 30% increase of breast cancer after estrogen treatment (> 5 years). The treatment with raloxifene decreases the risk of breast cancer, of osteoporosis and of coronary events but it induces hot flushes. The administration of other hormones (T, DHEA and STH) could improve muscle strength, osteoporosis and libido (T, DHEA) and well being (STH, DHEA) but C-V and oncogenic risks beyond 3 years of treatment are unknown. A hormonal treatment is probably no better than regular physical exercise and a Mediterranean diet (M.diet). The latter is characterized by a high consumption of vegetables, fruits, fish and cereals, by a moderate intake of olive oil, wine and milky products and a low intake of meat. The properties of these different components are reviewed as well as the antiarrhythmic effects of omega 3 fatty acids (eicosapentanoic acid and alpha-linolenic acid). The M.diet could also have a protective effect on the coronary events in secondary prevention. The difficulty to change life style and food patterns is analysed in comparison to the long time oral administration of drugs such as statins.
 ...
PMID:[Prevention of cardiovascular and degenerative diseases: II. Hormones and/or Mediterranean diet]. 1509 5