Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0600142 (hot flushes)
 1,242 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

488 women have been asked after abdominal or vaginal hysterectomy by way of retrospective questionnaires about preoperative anxieties, postoperative psychosomatic complaints as well as disturbances of their vita sexualis. 48.6% of the patients had anxieties before operation and anaesthesia. After hysterectomy 71.9% of the women reported about hot flushes and other psycho-vegetative complaints. Although hot flushes occurred significantly more frequent in patients with salpingooophorectomy they could be observed also in one third of the women without removal of the ovaries. However libido, cohabitation frequency and orgasm ability were reduced significantly more frequent in the group of women after hysterectomy with salpingooophorectomy. This is caused by the failing blood supply to the ovary via the branches of the uterine artery. The reduce postoperative psychosomatic complaints as well as sexual dysfunctions it is important to give qualited instructions before and after the operation. On no account should a prophylactic exstirpation of the adnexa be carried out before the age of 50 years. A hormonal substitution is recommended to be done in time even for patients whose ovaries have not been removed suffering from psycho-somatio discomforts.
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PMID:[Attitude and sex behavior following hysterectomy]. 292 78

The present studies evaluated the effect of estrogens and the selective estrogen receptor modulator (SERM) tamoxifen and raloxifene in a rat model for hot flush. In this model, ovariectomized rats were treated for 8 or 9 days either sc or po. Rats were dependent to morphine by implanting a morphine pellet (75 mg each) sc on days 3 and 5 of treatment. On the last day of treatment, a thermistor, connected to a data acquisition system, was placed on the tail of each animal and morphine addiction was withdrawn by naloxone injection (1.0 mg/kg, sc). Temperature measurements were taken for 1 h under ketamine (80 mg/kg, im) anesthesia. In general, vehicle treated rats showed a 5-6 degrees C elevation of their tail skin temperature with the peak occurring about 15 min after naloxone injection. 17 alpha-Ethinyl estradiol (EE) was evaluated both sc and po using a broad range of doses. The IC50 for inhibition of tail skin temperature rise was approximately 0.1 mg/kg, sc and 0.2 mg/kg, po. 17 beta-Estradiol and 17 alpha-estradiol were also active in this model whereas non-estrogenic steroids were inactive. Raloxifene and tamoxifen were tested for estrogen agonist and antagonist activity administered sc and po. Raloxifene did not demonstrate reproducible estrogen agonist activity at doses up to 10 mg/kg, whereas it demonstrated significant antagonistic activity at the 10 mg/kg dose regardless of the route of administration. Tamoxifen exhibited significant estrogen agonist activity at all doses tested (0.1-10.0 mg/kg) and was a significant antagonist of EE at the 1.0 mg/kg dose. Our results demonstrate the potential utility of this model to evaluate and discriminate among classes of compounds with varying degrees of estrogen agonist and antagonist activity.
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PMID:The effect of estrogens and antiestrogens in a rat model for hot flush. 988 31

Significant fetal bradycardia occurred when a parturient receiving labor epidural analgesia experienced generalized numbness and tingling, a metallic taste and hot flushes. An emergent cesarean delivery under general anesthesia was performed with favorable outcomes for the mother and baby. The most likely source of the maternal symptoms was spiramycin, which was being administered for treatment of toxoplasmosis.
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PMID:Side effects of spiramycin masquerading as local anesthetic toxicity during labor epidural analgesia. 2062 89