Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0600142 (hot flushes)
 1,242 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to investigate the relationship between hot flushes and LH-peaks, we applied GnRH-Analogon for pharmacological hypophysectomy. Although the gonadotropin serum levels could be normalized, none of the women showed a cessation of the flushes. Therefore it can be assumed that not gonadotropins, but neurotransmitters are involved in the development of flushes. The determination of the serum-level of vasointestinal peptide in the course of a TRH-test showed high VIP levels only in two climacteric women. To verify the suspected relation of VIP to the climacterium, a larger collective of women has to be checked.
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PMID:[Neuroendocrine changes in the climacteric]. 296 Nov 33

Studies were performed on the correlation between the hypothalamic temperature-sensitive neurons and hypothalamic neurons sensitive to LHRH, TRH, conjugated estrogen and clomiphene in 103 castrated matured female rats by the technique of microiontophoresis using a multi-barrel glass microelectrode. Out of 348 neurons in the hypothalamus, 24 neurons were found to be LHRH-sensitive, 20 TRH-sensitive, 41 estrogen-sensitive, and 18 clomiphene-sensitive. There were 19(28.8%) warm-sensitive and 11(16.7%) cold-sensitive neurons located in the preoptic area. From among the 19 warm-sensitive neurons, 14 neurons showed excitation by estrogen and 4 showed suppression by LHRH. Out of the 11 cold-sensitive neurons, estrogen, LHRH, and TRH excited 4, 3, and 3 neurons, respectively. It is suggested from these studies that LHRH mainly exhibits its thermo-regulatory functions by exciting warm-sensitive neurons and it is for this reason that exogenous estrogens are effective in alleviating hot flushes in natural as well as post-operative menopause which are thought to be caused by LHRH.
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PMID:[Effects of iontophoretically-applied LHRH, TRH, estrogen and clomiphene on thermo-sensitive neurons in the rat hypothalamus]. 392 34