Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0600139 (Prostate Cancer)
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Human Gene/Protein
G protein-coupled receptor 107 12.8
KOX30 12.8
ZNF359 11.8
Zfp-1 11.2
ZNF19 11.2
C10orf88 11.2
Ring finger protein 1 10.8
ZNF23 10.8
FRA10A 10.5
FAM9B 10.5
Flamingo1 10.5
ZNF32 10.5
ZNF236 10.5
p27 kip1 10.2
HSCB 9.8
TRPM2 protein 9.8
PRPF40A 9.6
ESO1 9.3
FBXW5 9.3
TPD52L2 9.3
prostate associated 9.3
PGLS 9.2
p53DINP1 9.2
UBAP2 9.2
HPC1 9.1
TLK1 9.1
bone-derived growth factor 8.9
PCDHA1 8.9
hereditary prostate cancer 8.8
PRAC 8.8
ICEBERG 8.8
secreted protein, acidic, cysteine-rich 8.8
KAI1 protein 8.8
Prostate specific antigen 8.7
pituitary tumor-transforming 1 8.7
regulator of G protein signaling protein 8.6
prostate-specific antigen 8.6
FRAT2 8.5
DLC3 8.5
KLK12 8.5
PSA 8.4
gamma-seminoprotein 8.3
STEAP 8.3
FBXW8 8.3
MAST2 8.3
TIP120A 8.3
PMEPA1 8.3
prostate specific antigen 8.2
KOX 8.2
PIK3AP1 8.1
KDM5D 8.1
5-alpha reductase 8.1
prostatic acid phosphatase 8.1
TP53INP2 8.1
PIK3C2A 8.0
NPCR 8.0
CAPB 8.0
TNRC9 8.0
PCLO 8.0
Nibrin 8.0
HPC2 7.9
transmembrane protease, serine 2 7.9
SEC23A 7.9
TNRC6B 7.9
ZBTB38 7.9
meiotic recombination 11 7.8
Fibroblast growth factor receptor 4 7.8
PSMC4 7.8
NADSYN1 7.8
PSGR 7.8
ERp46 7.7
RFX6 7.7
PIK3C2B 7.7
TERE1 7.7
SQLE 7.7
Tur 7.6
CSNK1E 7.6
KLK13 7.5
RGS17 7.5
RNASEL 7.5
more...
Disease
Prostate Cancer 12.8
High Grade Prostatic Intraepithelial Neoplasia 12.8
Bladder neck sclerosis 11.8
Mietens' syndrome 10.8
Adenosquamous cell carcinoma 10.6
stage A prostate cancer 10.4
Spastic quadriparesis 10.2
prostatic disease 10.0
HPCX 10.0
stage C prostate cancer 9.9
HPC1 9.9
High grade prostatic intraepithelial neoplasia 9.3
Metastatic Prostate Cancer 9.2
stage D prostate cancer 9.1
stage B prostate cancer 8.8
Genitourinary Cancers 8.7
prostate cancer 8.6
urinary system cancer 8.6
Endometrioid carcinoma 8.6
trigonitis 8.5
PSA 8.4
Medullary Thyroid Carcinoma 8.3
Prostate tumor 8.2
prostatic adenocarcinoma 8.1
recurrent prostate cancer 8.1
Mediastinal lymphadenopathy 7.9
androgen independent prostate cancer 7.9
Jacksonian seizures 7.8
Adenosquamous carcinoma 7.7
Numb chin syndrome 7.7
hormone refractory prostate cancer 7.6
salivary gland adenoid cystic carcinoma 7.5
Struck 7.5
PIN 7.5
melanoma stage 7.4
Metastatic carcinoma 7.4
high-risk cancer 7.3
NEK1 7.3
Prostatitis 7.2
Hurthle cell adenoma 7.2
PanIN-2 7.2
urethral cancer 7.2
prostatic obstruction 7.2
Small cell carcinoma 7.1
bilateral cancer 7.1
Malignant disease 7.0
bladder neck obstruction 7.0
Testicular Cancer 6.9
IFD 6.9
Sarcomatoid carcinoma 6.8
prostatitis 6.7
Escherichia coli meningitis 6.6
carcinoma of unknown origin 6.6
Ovarian Cancer 6.6
Epithelial hyperplasia 6.6
ASAP 6.6
Epididymis 6.5
Epididymis 6.5
carcinoma of the bladder 6.5
bone metastases 6.5
prostatic adenoma 6.5
BMH 6.5
proctitis 6.5
Kidney Cancer 6.5
PIN 6.4
locally advanced cancer 6.4
lymphocele 6.3
seminal vesicles 6.3
Nephrogenic adenoma 6.2
Cerebral metastases 6.2
carcinoma of the uterus 6.2
childhood rhabdomyosarcoma 6.2
Localized disease 6.2
polyradiculitis 6.2
Hyperplasia 6.2
Androgen deficiency 6.1
Stewart-Treves syndrome 6.1
in situ breast cancer 6.1
gynecomastia 6.0
generalized disease 6.0
more...
Symptom
Total incontinence 10.5
Chills and fever 9.5
unable to urinate 8.8
Chronic pelvic pain syndrome 7.9
prostatism 6.9
Lower urinary tract symptoms 6.8
Urge incontinence 6.7
hot flashes 6.2
bone pain 6.2
Acute urinary retention 5.8
hot flushes 5.5
urinary frequency 5.4
dysuria 5.4
rectal pain 5.2
chyluria 5.2
dyschezia 5.0
leg edema 5.0
tenesmus 4.9
anal pain 4.9
pelvic pain 3.8
asthenia 3.4
rigors 3.1
masculinization 3.0
memory loss 3.0
Hudson 2.7
decreased appetite 2.6
numbness 2.4
tonic-clonic seizure 2.4
physical appearance 2.2
hip pain 2.0
sneezing 1.9
blurred vision 1.8
flank pain 1.7
discomfort 1.6
back pain 1.5
discomfort 1.5
fatigue 1.4
pain 1.4
paraparesis 1.3
analgesia 1.2
weakness 1.2
sleepiness 1.1
nausea 1.1
epigastric pain 1.0
vertigo 1.0
cerebellar ataxia 1.0
overweight 0.7
diarrhea 0.7
nausea and vomiting 0.5
dizziness 0.5
paresthesia 0.5
low back pain 0.5
anesthesia 0.5
constipation 0.5
shortness of breath 0.4
ENT 0.4
Ill 0.3
flushing 0.1
myalgia 0.1
anorexia 0.0
abdominal pain -0.2
insomnia -0.6
vomiting -0.6
headache -0.7
cough -0.8
erythema -0.9
stigma -0.9
functional recovery -0.9
exhaustion -1.0
ataxia -1.2
chest pain -1.3
respiratory distress -1.5
dyspnea -2.0
seizures -3.5
Drug
Dutasteride 10.7
Hytrin 9.8
Anandron 9.7
Eulexin 9.6
Estracyt 9.5
Estracyt 9.5
Hytrin 9.5
Casodex 9.4
Epristeride 9.2
Emcyt 9.1
Zoladex 8.8
Fareston 8.7
Abarelix 8.7
Tamsulosin hydrochloride 8.6
Zoladex 8.5
Alfuzosin 8.3
Rocaltrol 8.3
Omnic 8.3
Cardura 8.1
Cardura 8.1
Finasteride 7.8
ProstaScint 7.8
Minipress 7.7
Eprinomectin 7.2
Lupron 7.1
Silodosin 7.1
Ethyol 7.0
Chloramine T 6.9
Zoledronic acid 6.6
Triptorelin 6.5
Sandostatin LAR 6.3
Valproic Acid 6.2
Zoledronic acid 5.9
TPV 5.9
R1881 5.8
PNT 5.7
Arimidex 5.6
Premarin 5.5
Docetaxel 5.5
KGF 5.4
Vitamin E 5.4
PDGF B-chain 5.3
Amifostine 5.3
Cetrorelix 5.2
Dihydrotestosterone 5.1
Luteinizing 5.1
ETS 4.9
Encore 4.9
EHDP 4.8
CDX 4.8
GNA 4.7
Mezlocillin 4.7
Denosumab 4.7
Sucralfate 4.7
Lactase 4.6
Sandostatin 4.5
Sandostatin 4.5
Menthol 4.5
DHT 4.5
DHT 4.4
CDX 4.4
Raloxifene 4.3
Doyle 4.1
MDM 4.1
Viagra 3.9
TAK 3.8
Leucovorin 3.8
Ketoconazole 3.7
Antithrombin III 3.7
uPA 3.7
Viagra 3.6
Metrizamide 3.6
Gefitinib 3.6
Urokinase 3.5
Taxotere 3.5
CFS 3.5
Tocopherol 3.3
Paraffin 3.3
Gelfoam 3.3
DMSA 3.2
more...
Enzyme
steroid 5-alpha-reductase 8.8
prostate-specific antigen 8.6
alpha-methylacyl-CoA racemase 7.5
5alpha-reductase 7.2
5alpha-reductase 7.2
KLK13 7.0
prostate-specific membrane antigen 6.8
hepsin 6.6
hepsin 6.6
N-acetylglucosaminyltransferase V 5.5
acid phosphatase 5.3
HDR 5.1
uracil phosphoribosyltransferase 5.1
3-mercaptopyruvate sulfurtransferase 4.9
Omi/HtrA2 4.4
cathepsin H 4.3
enolase 4.1
CGT 4.0
MDP 4.0
SCP 4.0
NPL 3.9
uroporphyrinogen decarboxylase 3.9
TRS 3.8
cystathionine gamma-lyase 3.7
aromatic L-amino acid decarboxylase 3.7
prenyltransferase 3.6
MTD 3.5
prenyltransferase 3.5
prenyltransferase 3.5
insulin-degrading enzyme 3.3
SST 3.2
TACE 3.1
dihydropyrimidine dehydrogenase 3.1
histone demethylase 2.9
cystathionine beta-synthase 2.9
urokinase-type plasminogen activator 2.9
thymidine phosphorylase 2.8
fumarase 2.6
15-lipoxygenase 2.6
kallikrein 2.5
dihydropyrimidine dehydrogenase 2.5
cathepsin D 2.3
aequorin 2.3
MAT 2.2
triphosphatase 2.2
dipeptidyl peptidase IV 2.1
DTA 2.1
PTA 2.0
PARP 2.0
MAT 2.0
AOR 2.0
prostaglandin synthetase 1.9
caspase-9 1.9
TdT 1.9
alkaline phosphatase 1.8
cdc2 1.8
CYP3A4 1.7
lactase 1.7
N-acetyltransferase 1.6
creatine kinase 1.6
thymidine kinase 1.5
myosin light chain kinase 1.4
micrococcal nuclease 1.3
lactate dehydrogenase 1.3
phosphodiesterase 1.2
ornithine decarboxylase 1.1
proteasome 1.1
UDP-glucuronosyltransferase 1.1
caspase-8 1.0
HSD 1.0
CD13 1.0
thymidylate synthase 1.0
NOS 0.9
phosphatidylinositol 3-kinase 0.9
PDE 0.9
PCP 0.9
tissue plasminogen activator 0.9
luciferase 0.9
phosphofructokinase 0.9
NADPH-diaphorase 0.8
more...
Compound
Diethylstilbestrol diphosphate 10.8
Bicalutamide 9.7
Estracyt 9.6
Estracyt 9.6
Dienestrol 8.9
Isobavachalcone 8.6
Ver A 8.6
4-methyl-2H-chromen-2-one 8.4
Pristimerin 8.0
Pristimerin 8.0
Pristimerin 8.0
Pristimerin 8.0
Nilutamide 8.0
Tamsulosin 7.8
Leuprolide 7.8
Minipress 7.7
Fenarimol 7.6
Glycolide 7.4
R 1881 7.3
Estramustine 7.2
VCC 6.9
Androgen 6.8
Adiol 6.6
1,4-pentadiene 6.4
Cyproterone acetate 6.4
Pyridinoline 6.4
Doxazosin 6.2
IDC 6.1
Lactide 6.0
Aminoglutethimide 6.0
Sarcosine 6.0
Mezlocillin 5.9
Toremifene 5.8
Digitoxin 5.8
Amonafide 5.8
PIN 5.8
AT-101 5.7
AT-101 5.7
Evodiamine 5.7
PNT 5.7
Docetaxel 5.7
AT-101 5.7
Evodiamine 5.6
FTA 5.5
Lupeol 5.5
Premarin 5.5
NEU 5.5
Kallikrein 5.4
CUE 5.3
CCC 5.2
Pargyline 5.1
Vitamin E 5.1
PAP 5.1
EHDP 5.1
12(S)-HETE 5.0
TIF 4.9
GBL 4.9
Mesna 4.8
PAP 4.8
PAP 4.8
Lycopene 4.8
Geldanamycin 4.8
benzohydrazide 4.8
methyl benzoate 4.8
PAP 4.8
Sucralfate 4.7
MHS 4.7
Premarin 4.6
HPC 4.6
HPC 4.6
DHT 4.6
androstane 4.5
DHC 4.5
Menthol 4.5
TIB 4.4
Raloxifene 4.4
Testosterone 4.4
Testosterone 4.4
Menthol 4.4
Spironolactone 4.3
more...