Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0600139 (Prostate Cancer)
 4,540 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The assay for the MB isoenzyme of creatine kinase is widely used in the diagnosis of acute myocardial infarction. Patients with metastatic carcinoma of the prostate may have an elevated serum creatine kinase BB fraction, which by immunoinhibition method may be read mistakenly as creatine kinase MB. We report the case of a patient with a history of myocardial injury, chest pain, total CK above of reference range and CK-MB isoenzyme, determinated with an immunoinhibition technique, larger than 100% of enzymatic activity of total CK, that was carrier of a prostatic adenocarcinoma in stage D2. We comment the diseases in which the CK-BB fraction may be elevated, discuss the laboratory methods for the determination of creatine kinase isoenzymes, and revised, briefly, the properties of the new immunoassays, that measure mass concentration of creatine kinase MB, in the diagnosis of acute myocardial infarction.
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PMID:[Can a prostatic adenocarcinoma simulate an acute myocardial infarction?]. 832 Oct 63

The measurement of creatine kinase isoenzymes, particularly the MB fraction, is a major determinant for acute myocardial infarction. Patients with metastatic carcinoma of the prostate may have an elevated serum creatine kinase-BB fraction, which by some automated laboratory techniques may be read mistakenly as creatine kinase-MB. We report such a case and discuss the creatine kinase isoenzyme measurement.
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PMID:Creatine kinase isoenzymes and prostatic carcinoma: metastatic disease or acute myocardial infarction? 672 45

The purpose of this study was to report the short-term results of open prostatectomy for benign prostatic hyperplasia (BPH). Patient charts were retrospectively reviewed from September 1988 to April 2004. A total of 3000 consecutive patients with bothersome lower urinary tract symptoms (LUTS) and complications of BPH underwent open prostatectomy in our center. We routinely used a retropubic, transcapsular approach with spinal anesthesia. Mean age was 69 years. Three hundred and sixty one patients were 80 years or older. Mean prostate volume was 71 ml. One thousand eight hundred and twenty five patients (60.8%) presented with and were operated on for acute urinary retention (AUR), and 350 patients (11.7%) presented with and were operated on for urge/overflow urinary incontinence. The main reasons for delayed presentation were poverty and absence of real medical insurance, because in Iran 'insured' patients pay at least 60% of their medical expenses personally. Reoperation in the same admission was needed in 29 patients (1%). Transfusions were needed in 99 patients (3.3%). Wound infection occurred in 37 patients (1.2%). Acute myocardial infarction (MI) occurred in 15 patients (0.5%), resulting in three deaths. Occurrence of AUR had significant negative correlation with duration of symptoms (P<0.05; odds ratio 0.5), and significant positive correlation with positive urine culture (P<0.05; odds ratio 2.7). Duration of hospital stay had significant positive correlation with positive urine culture (P<0.05; odds ratio 1.6) and advanced age (P<0.05; odds ratio 1.8), and significant negative correlation with prostate volume (P<0.05; odds ratio 0.6). Our results are representative of the current status of open prostatectomy. Whenever minimally invasive therapies are not affordable retropubic prostatectomy is a practical alternative.
Prostate Cancer Prostatic Dis 2007
PMID:Open prostatectomy for benign prostate hyperplasia: short-term outcome in 3000 consecutive patients. 1754 69

Objective. To construct a database for clinical epidemiological prostate cancer research based on linkages between the National Prostate Cancer Register (NPCR) of Sweden, a population-based, nationwide quality database, and other nationwide registries. Material and methods. By use of the individually unique Swedish Personal Identity Number, the NPCR was linked to the Swedish Cancer Registry, the Cause of Death Register, the Prescribed Drug Register, the National Patient Register and the Acute Myocardial Infarction Register, all held at the Centre for Epidemiology at the National Board of Health and Welfare, and the Register of the Total Population, the Longitudinal Integration Database for Health Insurance and Labor Market Studies and the Multi-Generation Register, held at Statistics Sweden, and to the Swedish Hernia Register. Results. Record linkages between the NPCR and the Swedish Cancer Registry, the Cause of Death Register and the Register of the Total Population generated a database, named PCBaSe Sweden, including 80 079 prostate cancer cases, diagnosed between 1 January 1996 and 31 December 2006. Record linkage between PCBaSe Sweden and the Prescribed Drug Register generated 59 721 unique matches and linkage to the Acute Myocardial Infarction Register resulted in 11 459 matches. Conclusion. PCBaSe Sweden is a newly created and unique database with over 80 000 cases of prostate cancer with comprehensive data on inpatient and outpatient care, patterns of use of prescribed drugs and socioeconomic and familial factors. Many topics in clinical prostate cancer epidemiology can be investigated. using PCBaSe Sweden.
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PMID:PCBaSe Sweden: a register-based resource for prostate cancer research. 1992 77