Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0600097 (Sedation)
 1,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study is one of in vivo 99mTc-DTPA renography, successively involving conscious healthy dogs under acepromazine maleate sedation and dogs under the narcotic sodium thiopental. It was found that during the running of the renogram the animal had to be kept completely immobile and that constant infusion narcosis with sodium thiopental produced this immobility without affecting the renograms unduly. However administration of a thiopental bolus did have an adverse effect on the renogram. Sedation with acepromazine maleate significantly increased the time to peak and the excretion phase as presented by the slope. These effects are thought to be due to a decreased blood pressure with concomitant renal bloodpooling and retarded bloodflow. The radioisotope renogram appears to hold great promise for both clinical and research applications. The equipment required for this application however, is so costly that it would only be financially feasible for major centres.
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PMID:The feasibility of a renogram study in dogs with radiopharmaceutical 99mTc-DTPA. 676 31

Twenty asymptomatic infants with cystic fibrosis (CF) were studied to determine the amount of radiolabeled aerosol [99m technetium diethylenetriamine penta acetic acid (Tc99m DTPA)] deposited in the respiratory system and its distribution. Aerosols were generated by jet nebulization systems that were used in the wards and the laboratory. Subjects were studied in three groups: group A (n = 10) was sedated with chloral hydrate; children inhaled an aerosol of 7.7 microns mass median diameter (MMD); group B (n = 5) was not sedated, using the same nebulization system (same aerosol particle size as group A); and group C (n = 5) was not sedated; these children inhaled an aerosol with an MMD of 3.6 microns. Normal saline plus 4 mCi of Tc99m bound to DTPA was added to each nebulizer. A closed system was used to collect the expired aerosol. Radioactivity in each infant and in the equipment was measured with a gamma camera on completion of nebulization. In groups A and B, the percentages of the total dose deposited in the lung were 0.97 +/- 0.35% and 0.76 +/- 0.36%, respectively. In group C, 2.0 +/- 0.71% was deposited in the lung (P < 0.01). Deposition in the nose, mouth, and pharynx was least in group C (P < 0.01). In groups A and B, the intrathoracic deposition occurred predominantly in the trachea and main bronchi, whereas in group C, significantly more aerosol was deposited in the lung region. There was marked inter-subject variability in the percentage of aerosol deposition within the three groups. There was no correlation between percentage of aerosol deposited in the respiratory system and age, height, or weight. Sedation did not have a significant effect on deposition of aerosol in infants. This study indicates that only a small proportion of nebulized solution is deposited in the lungs of infants and that this proportion is influenced by the particle size of the aerosol. The smaller particle size (3.6 microns MMD) was deposited in the lung better than large particles.
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PMID:Aerosol deposition in infants with cystic fibrosis. 872 52