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Query: UMLS:C0600097 (Sedation)
 1,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen adults, hospitalized for fiberoptic endoscopy studies, were tested under two conditions using impedance audiometry. The first series of tests was conducted prior to the fiberoptic studies and sedation; the second immediately following examination, approximately 20 minutes after sedation with diazepam (Valium) and meperidine (Demerol) hydrochloride. Sedation with diazepam and meperidine failed to have a significant effect on tympanometry, static compliance, or differential loudness. These drugs were therefore considered effective sedatives for conducting impedance studies on difficult-to-test patients. This procedure is not recommended as a routine procedure and should be done only as a last resort.
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PMID:The effects of sedation on the impedance test battery. 84 2

While instituting a new program in fetoscopy, the authors explored the effects of sedation with meperidine (Demerol) and promethazine HCl (Phenergan) during fetoscopy conducted on 10 mothers at 14 to 18 weeks' gestation. Each received 100 mg of meperidine and 50 mg of promethazine HCl approximately 30 minutes before the procedure. In 3 instances, a repeat half-dose injection was made at 30 minutes for adequate analgesia. Sex of the fetus was determined accurately in 9 instances. In 9 of 10 cases, visualization was satisfactory; technical problems in 1 case precluded visualization. Complications included 2 superficial fetal limb hematomas and 2 instances of minimal fetal bleeding from an unknown site. Three patients required perforation of anterior placentas. Amniotic fluid was invariably clear but became progressively turbid. Sedation allowed a longer period for clear amniotic fluid by decreasing fetal movements progressively over the first hour; fetal activity showed a prompt return thereafter. The clarity of the amniotic fluid was adversely influenced by external manipulation of the fetus. The authors conclude that sedation has obvious benefits for the mother and may facilitate evaluation of the fetus during fetoscopy.
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PMID:Effects of maternal sedation during fetoscopy. 739 15