Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0599766 (functional recovery)
 13,441 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two bispyridinium oximes, BDB-27 and HGG-12, were tested in vivo for their ability to restore neuromuscular function in rats poisoned by 1.3 LD50 of sarin, soman, tabun and XV, using isolated phrenic nerve-diaphragm preparation. Their effectiveness was evaluated in comparison with the two most potent oximes in this respect, HI-6 and TMB-4. It was found that BDB-27 was equal or superior to HI-6 in sarin, soman and XV and to TMB-4 in tabun poisoned animals. Recovery of function after HGG-12 was equal to HI-6 only in soman poisoning, but much less pronounced against neuromuscular blockade induced by the other three anticholinesterases. The results point at the equal effectiveness of BDB-27 in functional recovery in poisoning by all four toxic agents tested, so far not encountered by any other oxime.
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PMID:The effect of bis-pyridinium oximes on neuromuscular blockade induced by highly toxic organophosphates in rat. 630 95

Pralidoxime chloride (pyridine-2-aldoxime methochloride; Protopam Chloride) and 1,1'-trimethylenebis(4-hydroxyiminomethylpyridinium bromide) (TMB-4) antagonize the spasm of the isolated or intact small intestine of the rabbit caused by the anticholinesterase, echothiophate iodide (S-2-dimethylaminoethyl OO-diethyl phosphorothiolate methiodide; Phospholine Iodide). In vitro, both oximes also antagonize the spasm caused by acetylcholine. The quantitative relationships have been studied in comparison with the activity of atropine against echothiophate and acetylcholine. Echothiophate-treated intestine which is subjected to a concentration of oxime sufficient to cause 100% restoration of function (but not cholinesterase reactivation) will go back into spasm on washing out both drugs. Strips treated with a high concentration of oxime, sufficient to cause 100% reactivation of cholinesterase, exhibit normal control tone and motility after washing. It is concluded that pralidoxime and 1,1'-trimethylenebis(4-hydroxyiminomethylpyridinium bromide) have an anticholinergic action as well as the ability to reactivate cholinesterase and that this action plays a significant part in the initial recovery of function under the conditions of these experiments.
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PMID:Mechanism of the antagonism by pralidoxime and 1,1-trimethylenebis(4-hydroxyiminomethylpyridinium) of the action of echothiphate on the intestine. 1446 53