Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0599766 (functional recovery)
 13,441 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventy patients with hypothalamus-pituitary diseases were studied. 13 of them were studied before surgical treatment and then 15-20 days and 6 months later. A comparison was made with 59 controls. In all these subjects PRL and TSH were studied under basal conditions and after TRH stimulation. As for TSH the highest percentage of abnormal responses was found in the group of patients with chromophobe adenoma and parasellar dysplasias. This area of the pituitary appears relatively undamaged in acromegalic patients. In clinically hypothyroid patients, normal or high TSH responses to TRH were often found. As for PRL, a hyperprolactinaemia was mostly found in the group of patients with chromophobe adenoma, parasellar dysplasias and craniopharyngioma, although there was a different pattern in the TSH responses. No correlation was found between the basal PRL levels and the TSH responses to TRH. There was no significant difference in the TSH responses of the patients with PRL secreting and non-secreting chromophobe adenomas. The hypothesis of two autonomous systems is supported by the finding of differences in the functional recovery of the two pituitary areas studied at different times after surgical treatment.
Ric Clin Lab
PMID:Thyrotropin and prolactin in patients with hypothalamus-pituitary diseases. 10 50

Subcutaneous rupture of the short head tendon of the biceps brachii is a very rare lesion, with only five cases previously reported. The case of a 67-year-old farmer whose tendon ruptured following a mild muscle effort is presented. The degenerative changes revealed by histological examination of the injured tendon were so severe as to lead to the conclusion that its tensile strength must have fallen considerably prior to rupture. The most characteristic clinical signs of this rupture are a sizeable bulge in the middle third of the injured arm, and a hollow in the site normally occupied by the short head of the biceps. Suture of the ruptured tendon to that of the coracobrachialis led to full functional recovery.
Clin Orthop Relat Res 1977 May
PMID:Rupture of the short head tendon of the biceps brachii. 59 82

A traumatic dislocation of the hip joint associated with an ipsilateral femoral shaft fracture is a rare injury resulting from severe trauma. Initially the dislocated hip joint is often unrecognized and consequently reduction is delayed. Early diagnosis and reduction of the hip joint improves the functional prognosis. The maximum functional recovery is possible only with greater awareness of this combined injury. Examination of the hip joints by clinical roentgenography in the critically injured patient, especially those with head injuries, or physical signs masked by extremity swelling, should be a routine procedure.
Clin Orthop Relat Res
PMID:Traumatic hip dislocation with ipsilateral femoral shaft fractures. 63 95

Twenty cases of patellectomy for fracture and 14 cases of patellectomy for chondromalacia evaluated for postoperative strength, endurance, pain and functional complaints, revealed satisfactory results in 85% of the fracture group and 79% of the chondromalacia group. Some quadriceps weakness was usually present, but quadriceps strengthening overcame the loss of mechanical efficiency caused by patellectomy. A vigorous rehabilitation program should be followed for at least one year after surgery to secure the fullest recovery of function.
Clin Orthop Relat Res 1978 May
PMID:Function after patellectomy. 67 37

Forty-four biopsies of transplanted kidneys undergoing rejection were examined by light microscopy without knowledge of the eventual clinical outcome. All patients received extensive antirejection medication. A scoring system based on nine histopathologic criteria was formulated to predict whether the serum creatinine would be less than 1.8 mg/dl (good prognosis), 1.8 to 2.5 mg/dl (fair), or greater than 2.5 mg/dl (poor), two months after biopsy. Predictions were accurate in 37 of the 44 cases. In some cases with relatively minimal vascular changes the prognosis was poor, whereas heavy cellular infiltreate without vessel damage did not necessarily preclude functional recovery. It was concluded that specific histopathologic pictures should enable the physician to decide whether to institute extensive antirejection therapy or adopt alternative measures.
Clin Nephrol 1976 Jun
PMID:Renal allograft biopsy: a satisfactory adjunct for predicting renal function after graft rejection. 77 79

The marked resurgence of interest and activity which has occurred in recent years in experimental spinal cord injuries is attributable to demonstrations of significant functional recovery in animal models. The recovery was possible after controlled cord trauma. The pathological characteristics of the experimentally produced spinal cord lesion, documented by recent light and electron microscopy studies, demonstrate: (1) the apparent early vulnerability of the central gray matter as opposed to the delay response of the surrounding white matter; (2) the important participation of the microvasculature in developing cord tissue lesion; (3) the important contribution that catacholamine release and substrate deprivation may have in the changes seen in the evolving tissue damage; and (4) the time dichotomy that exists between the immediate degree of functional disability and the period of time required for the tissue lesion to reach histological irreversibility.
Clin Orthop Relat Res 1975 Oct
PMID:Pathology of spinal cord injury in experimental lesions. 81 17

A prospective study of randomized analysis treatment of 50 cases of frozen shoulder was carried out in 3 Swiss medical centres. Three separate aetiological groups were studied: post-traumatic (40%), neurological (14%) and idiopathic (46%). An increased radioisotope bone scan (99 mTc diphosphonate) was found in 96% of cases, regardless of aetiology. The so-called idiopathic frozen shoulder showed a scapulo-humeral increase in radioisotope uptake in several areas (in 82% of cases) without involvement of the ipsilateral carpus. Clinically, the neurological type was associated with a shoulder-hand syndrome with positive bone scan of the shoulder and the wrist in all cases. The post-traumatic type showed a diffuse (in 50% of the cases) or at several circumscribed areas (also in 50%) increase in radioisotope uptake in the shoulder. In 45% of the post-traumatic type, there was also a shoulder-hand syndrome with uptake in the wrist also. A physical treatment and early mobilization, associated with the administration of subcutaneous salmon calcitonin for 21 days (100 U Calcitonin Sandoz) had a statistically significant increased effect on pain compared to treatment with physiotherapy alone by patients with post-traumatic frozen shoulders (p < 0.02). There was no significant difference, however, in the speed of recovery of function between the two treatment groups. These observations strengthen the hypothesis that adhesive capsulitis behave like an algoneurodystrophic process.
Clin Rheumatol 1992 Sep
PMID:The frozen shoulder: diagnosis and treatment. Prospective study of 50 cases of adhesive capsulitis. 128 Oct 62

The study population was composed of 43 patients affected by idiopathic facial paralysis (20 males and 23 females), aged between 11 and 67. The study was carried out in a double-blind, randomized, placebo controlled manner. Acetyl-L-carnitine was given in an oral dose of 3 x 1 g daily for 1 month, along with a daily oral administration of 50 mg of methylprednisolone for 14 days. The evaluation was made by means of electromyograms (EMG) of the orbicularis oculi and oris muscles, by the Schirmes lacrimation test, by stapedial reflex test and a score scale for clinical assessment of paralysis. Results so far obtained have shown an earlier functional recovery of the nerve in those patients treated with acetyl-L-carnitine. Comparison between the affected and unaffected sides of the face revealed a statistical significance in the treated group (p < 0.05) as well as the amplitudes of the muscle action potentials (MAP) between the affected sides (p < 0.01).
Int J Clin Pharmacol Res 1992
PMID:Idiopathic facial paralysis: new therapeutic prospects with acetyl-L-carnitine. 130 9

Three cases of aberrant nerve fibres in the spinal cord and medulla oblongata are described. The literature on these fibres is discussed and their possible role in regeneration. Different views on the possibility of regeneration or functional recovery of the central nervous system are mentioned in the light of recent publications, which are more optimistic than before.
Clin Neurol Neurosurg 1992
PMID:Aberrant nerve fibres within the central nervous system. 132 Apr 87

The duration of the blocking effect of salmeterol (50 micrograms), albuterol (200 micrograms), and a placebo were compared in a double-blind study in 12 adult subjects with asthma who underwent hyperventilation tests with cold dry air (-20 degrees C) on 4 study days. On the first day, the hyperventilation test was performed at various time intervals (baseline, 1, 4, 6, 8, 12, and 24 hours) with spontaneous functional recovery between each test to determine the within-day within-subject variability of the response. The response was assessed by interpolating the dose of cold dry air causing a 20% fall in FEV1. On the 3 remaining days, separated by an interval of at least 5 days, the active or placebo medication was administered after spontaneous recovery from the first hyperventilation test. Spirometry was assessed 15 minutes and 1 hour later. The hyperventilation test was then performed and repeated 4 hours after administration of the drug. The test was repeated 6, 8, 12, and 24 hours later to detect any significant blocking effect. The improvement in FEV1 15 minutes and 1 hour after the drug was administered was 19.8% and 20.4%, as compared to baseline for albuterol, and 16.3% and 16.8% for salmeterol (not significant). The mean duration of the blocking effect was 0.25 hour for the placebo, 3.5 hours for albuterol, and 15.9 hours for salmeterol (F = 24.5; p less than 0.001; Newman-Keul's test was significant for every contrast). Eight of the 12 subjects still demonstrated some blocking effect 8 hours after taking salmeterol; this was true for only one subject receiving albuterol.(ABSTRACT TRUNCATED AT 250 WORDS)
J Allergy Clin Immunol 1992 Feb
PMID:Salmeterol, a new inhaled beta 2-adrenergic agonist, has a longer blocking effect than albuterol on hyperventilation-induced bronchoconstriction. 134 93


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