Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0599766 (functional recovery)
 13,441 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Segmental bone loss secondary to trauma and infection often requires prosthetic components to provide for limb salvage and functional restoration. Current limb salvage techniques and implants are associated with up to a 46% rate of loosening and eventual failure [Clin Orthop Rel Res 1999;358:8]. This case report describes the use of a custom prosthesis for salvage total hip arthroplasty after a proximal femoral resection, for a patient with a history of a comminuted hip fracture and subsequent postoperative infection. Two component parts of the salvage prosthesis were a modular porous tantalum sleeve (Trabecular Metal, Zimmer TMT, Allendale, NJ) and a porous tantalum inset and washer intended for reattachment of the abductors. Throughout the 3-year follow-up of this patient, functional recovery and pain relief were obtained with few limitations.
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PMID:Limb salvage and abductor reattachment using a custom prosthesis with porous tantalum components. 1566 72

The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain.
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PMID:Odor memory stability after reinnervation of the olfactory bulb. 2307 57