Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0599766 (functional recovery)
 13,441 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Preservation of local muscular structures, and closure of the capsulo-periosteum detachment, are the two essential principles observed, when treating recurrent anterior shoulder dislocation by pre-glenoid stapling and also afford satisfactory results. This technique is used for capsulo-ligamentar lesions without alterations of the anterior edge of the glenoid cavity. If the strict technique is followed when placing the staple excellent stability result. If physiotherapy is started early, functional recovery is rapid. Sporting activities can be resumed within the third month after the operation.
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PMID:[Treatment of recurrent anterior dislocations of the shoulder by the technic of pre-glenoid stapling. Study of a series of 48 cases]. 380 73

A review of the English language literature establishes athletic mishaps as a major cause of posterior cruciate ligament injury. However, diversity of opinion exists regarding the functional significance of the lesion, its occurrence as an isolated entity, and the roles of conservative and surgical management. The posterior cruciate ligament is a composite structure, consisting of a superficial tibiofemoral and meniscofemoral portion and a deep tibiofemoral portion. The structure is intra-articular but extrasynovial, coursing from its attachment to the lateral surface of the medial femoral condyle posteriorly and inferiorly to its distal attachment into the posterior rim of the tibia, blending with the capsule and periosteum. Mechanical studies have demonstrated that abnormal posterior tibial displacement can occur only with posterior cruciate ligament laxity. The most prevalent mechanism resulting in injury to the posterior cruciate results from a blow on the anterior aspect of the flexed knee. However, both hyperflexion and hyperextension as well as deceleration and rotation have been described. Posterior cruciate ligament insufficiency may result from an avulsion fracture involving the ligament-bone insertion of the ligament, usually from the posterior aspect of the proximal tibia. Also, disruption may occur as an intersubstance tear of the ligament, either as an isolated phenomenon or in combination with multiple ligamentous injuries. The importance of distinguishing between combined injuries associated with significant collateral and/or anterior cruciate ligament injuries from the 'isolated' type lies in the fact that the prognosis for the 'isolated' injuries is much better. Careful clinical evaluation of the knee with an acute posterior cruciate ligament injury will reveal subtle, but definite, findings peculiar to the lesion. These include the posterior sag sign, the posterior drawer sign, reverse pivot shift, Godfrey's test, and the presence of varus or valgus instability with the joint in full extension. In patients with chronic posterior cruciate ligament laxity, the presenting symptom is often that of patellar pain. It is generally agreed that avulsion fractures involving the ligament-bone insertion of the posterior cruciate ligament should be treated by open reduction and internal fixation. Surgical treatment of this lesion will result in excellent functional recovery. A variety of procedures have been reported for the management of acute disruption of the posterior cruciate ligament.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Posterior cruciate ligament insufficiency. A review of the literature. 639 Jun 11

Traumatic bone defects in the diaphyso-metaphyseal distal part of the femur are difficult to treat. Only two publications have described traumatic extrusion of a femoral shaft fragment and its successful replacement after autoclave sterilisation. We report the case of a 17-year-old patient who had traumatic extrusion of an 11- cm segment of his distal femur. The bone segment was retrieved on the road, and was reimplanted in its anatomical position after cleansing and autoclaving. At ten years follow-up, there is complete incorporation with full functional recovery. The preserved periosteum seems to have played a major part in this successful outcome.
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PMID:Traumatic femoral bone defect reconstruction with an autoclaved autologous femoral segment. A 10-year follow-up. 1676 73

Although skeletal pain can have a marked impact on a patient's functional status and quality of life, relatively little is known about the specific populations of peripheral nerve fibers that drive non-malignant bone pain. In the present report, neonatal male Sprague-Dawley rats were treated with capsaicin or vehicle and femoral fracture was produced when the animals were young adults (15-16 weeks old). Capsaicin treatment, but not vehicle, resulted in a significant (>70%) depletion in the density of calcitonin-gene related peptide positive (CGRP(+)) sensory nerve fibers, but not 200 kDa neurofilament H positive (NF200(+)) sensory nerve fibers in the periosteum. The periosteum is a thin, cellular and fibrous tissue that tightly adheres to the outer surface of all but the articulated surface of bone and appears to play a pivotal role in driving fracture pain. In animals treated with capsaicin, but not vehicle, there was a 50% reduction in the severity, but no change in the time course, of fracture-induced skeletal pain-related behaviors as measured by spontaneous flinching, guarding and weight bearing. These results suggest that both capsaicin-sensitive (primarily CGRP(+) C-fibers) and capsaicin-insensitive (primarily NF200(+) A-delta fibers) sensory nerve fibers participate in driving skeletal fracture pain. Skeletal pain can be a significant impediment to functional recovery following trauma-induced fracture, osteoporosis-induced fracture and orthopedic surgery procedures such as knee and hip replacement. Understanding the specific populations of sensory nerve fibers that need to be targeted to inhibit the generation and maintenance of skeletal pain may allow the development of more specific mechanism-based therapies that can effectively attenuate acute and chronic skeletal pain.
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PMID:Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain. 1948 28

Nowadays, fracture surgery represents a big part of the orthopedic surgeon workload, and usually has associated major clinical and social cost implications. These fractures have several complications. Some of these are medical, and other related to the surgical treatment itself. Medical complications may affect around 20% of patients with hip fracture. Cognitive and neurological alterations, cardiopulmonary affections (alone or combined), venous thromboembolism, gastrointestinal tract bleeding, urinary tract complications, perioperative anemia, electrolytic and metabolic disorders, and pressure scars are the most important medical complications after hip surgery in terms of frequency, increase of length of stay and perioperative mortality. Complications arising from hip fracture surgery are fairly common, and vary depending on whether the fracture is intracapsular or extracapsular. The main problems in intracapsular fractures are biological: vascularization of the femoral head, and lack of periosteum -a major contributor to fracture healing- in the femoral neck. In extracapsular fractures, by contrast, the problem is mechanical, and relates to load-bearing. Early surgical fixation, the role of anti-thromboembolic and anti-infective prophylaxis, good pain control at the perioperative, detection and management of delirium, correct urinary tract management, avoidance of malnutrition, vitamin D supplementation, osteoporosis treatment and advancement of early mobilization to improve functional recovery and falls prevention are basic recommendations for an optimal maintenance of hip fractured patients.
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PMID:Complications of hip fractures: A review. 2523 17