Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598934 (
tumor growth
)
58,965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (
PTP(CAAXI)
and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified.
PTP(CAAXI)
and PTP(CAAX2) were farnesylated in vitro by mammalian farnesyl:protein transferase, and epitope-tagged PTP(CAAX2) was prenylated in epithelial cells. Overexpression of
PTP(CAAXI)
and PTP(CAAX2) in epithelial cells caused a transformed phenotype in culture and
tumor growth
in nude mice. Thus,
PTP(CAAXI)
and PTP(CAAX2) represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases.
...
PMID:Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. 901 80
