Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0598934 (
tumor growth
)
58,965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The KRAB-zinc-finger protein
ZNF545
was recently identified as a potential suppressor gene in several tumors. However, the regulatory mechanisms of
ZNF545
in tumorigenesis remain unclear. In this study, we investigated the expression and roles of
ZNF545
in multiple myeloma (MM).
ZNF545
was frequently downregulated in MM tissues compared with non-tumor bone marrow tissues.
ZNF545
expression was silenced by promoter methylation in MM cell lines, and could be restored by demethylation treatment.
ZNF545
methylation was detected in 28.3% of MM tissues, compared with 4.3% of normal bone marrow tissues.
ZNF545
transcriptionally activated the p53 signaling pathway but had no effect on Akt in MM, whereas ectopic expression of
ZNF545
in silenced cells suppressed their proliferation and induced apoptosis. We therefore identified
ZNF545
as a novel tumor suppressor inhibiting
tumor growth
through activation of the p53 pathway in MM. Moreover, tumor-specific methylation of
ZNF545
may represent an epigenetic biomarker for MM diagnosis, and a potential target for specific therapy.
...
PMID:Epigenetic identification of ZNF545 as a functional tumor suppressor in multiple myeloma via activation of p53 signaling pathway. 2715 Jun 32
Hepatocellular carcinoma (HCC) is one of the most common cancers and the second leading cause of cancer related death worldwide.
ZNF545
is located in the chromosome 19q13.13, which is frequent loss of heterozygosity in human astrocytoma. Methylation of
ZNF545
was found frequently in a few kinds of cancers. While the function of
ZNF545
in human HCC remains unclear. The purpose of this study is to explore the function and mechanism of
ZNF545
in human HCC. Restoration of
ZNF545
expression suppressed cell proliferation, migration and invasion, induced G1/S arrest and apoptosis in SNU449 and Huh7 cells. Further study suggested that
ZNF545
suppressed HCC cell growth by inhibiting NF-kB signaling. These results were further validated by siRNA knocking down technique in
ZNF545
highly expressed HXBF344 cells. In vivo,
ZNF545
suppressed
tumor growth
in SNU449 cell xenograft mice. In conclusion,
ZNF545
suppresses human HCC growth by inhibiting NF-kB signaling.
...
PMID:ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling. 2868 May 37
